Protein Alignment Hnf4 and nhr-153

DIOPT Version :9

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001355367.1
• Gene: nhr-153 / 182564
• WormBaseID: WBGene00007546
• Length: 442
• Species: Caenorhabditis elegans
• Alignment Length: 476
• Identity: 102/476 - (21%)
• Similarity: 168/476 - (35%)
• Gaps: 149/476 - (31%)

  Fly   100 SNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQ-QQQ 163
            |..|:...|.|.:|             .||...:...:.:|...     |....:::::.: ..|
 Worm     3 SKDSDSPPETFEVC-------------ISSPEIHKKEIMTPPQK-----SKPKRNRRKIYKILPQ 49

  Fly   164 QQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNC-----VVDKDKRNQCR 223
            .|.|:||.||.:.|.|.||...||:|||.||||::....::.|....||     |:|..|| .||
 Worm    50 NQCPSVCQICRNPAIGYHYEVPSCNGCKTFFRRTIITGRKFKCFKVSNCLDGNDVIDTSKR-VCR 113

  Fly   224 YCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNGLSVISLVKAEN--------------- 273
            .||..||.:|||...|:|.|.           ..|.|..|..:...|.||
 Worm   114 ACRFEKCVQAGMNPMAIQAEA-----------KTDEGEELKKLIAKKFENGEKLNDGTVFFNVHD 167

  Fly   274 ------------ESRQSKA-------GAAMEPNINEDLSNKQFASINDVCESMK----------- 308
                        |::..|.       |...:.:::..||:|...: |....||.
 Worm   168 RLNQILGKLIKIETKLEKVHDNGMPMGFLDQRDLSTALSSKVIYN-NMEIPSMSYTPVKISKNTG 231

  Fly   309 -----------QQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM--------H 354
                       ...|..:|::|.....:.:.:..::.||:..|       ||..::        .
 Worm   232 LPKRRSRNFVHSSCLASIEYSKTFDFSSAIDISSKIILLKNTA-------LSCANLTNAYTTFRK 289

  Fly   355 LK-DVLLLSNNCVI--TRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFF 416
            || |.||..:..:.  .|....||:......      :.:.|::.|.: .:|.||:..:||:|..
 Worm   290 LKSDTLLYPDGSIYGPPRRKNGPLIEKQRSF------LQNTLISFMTN-NVDKTEYILLKAIVLC 347

  Fly   417 DP--------NAKGLNEPHRIKS--------LRHQILNNLEDYISDRQYESRGRFGEILLILPVL 465
            :|        ::|.:.....:.:        |:|..|:            ...||..:|.|..||
 Worm   348 NPAIIDLPYADSKHIQREREVYAQCLFRYCLLQHGTLH------------GPARFSALLSIFNVL 400

  Fly   466 QSITWQMIEQIQFAKIFGVAH 486
            ::   |..||..:.....:.|
 Worm   401 EN---QQKEQKDYYLYIKLIH 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	35/79 (44%)
		NR_LBD_HNF4_like	264..494	CDD:132729	51/306 (17%)
nhr-153	NP_001355367.1	NR_DBD_HNF4A	56..133	CDD:143518	34/77 (44%)
		HOLI	242..403	CDD:214658	35/189 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010