Protein Alignment Hnf4 and nhr-35

DIOPT Version :9

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001024365.1
• Gene: nhr-35 / 180725
• WormBaseID: WBGene00003628
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 443
• Identity: 150/443 - (33%)
• Similarity: 224/443 - (50%)
• Gaps: 53/443 - (11%)

  Fly   146 GSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFAR 210
            |...||.:...:.:...:..|  :|.||.|.|||:||||.:|:||||||||:||:|::|.|||..
 Worm    55 GQMLGTYNGDSKAETDGKDNS--ICHICSDVATGRHYGAIACNGCKGFFRRTVRRNYEYHCRFES 117

  Fly   211 NCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCR------RTSNDDPDPGNG----LSV 265
            .|.:||..|..|||||..||..:||:.:.||:|||.|..|      :|...||.|...    :|.
 Worm   118 KCEIDKHNRAVCRYCRFMKCISSGMRDDQVQSERDVIGKREKKDNMKTYCQDPTPRTSPELTMSP 182

  Fly   266 I---------SLVKAENESRQSKAGAAMEPNINEDLSNK---------QFASINDVCESMKQQLL 312
            :         ||:|:| .:.||.....:....|.:.:.|         :.|::|||.:||..|||
 Worm   183 VEDEYDQLLESLLKSE-MTIQSLRDTVITQTGNVEYTTKSKNRLSHTDRTATLNDVLKSMHSQLL 246

  Fly   313 TLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVS 377
            .::||||.:|.|.:|...||..||:..||:|:.|.::.||:...|.|.|.|:..|.|...   .:
 Worm   247 LVIEWAKTLPEFKQLSGADQAVLLKNFAGQHVTLCVAYRSVGANDALKLLNDLYIPRASK---TT 308

  Fly   378 PNLD------ISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIK---SLR 433
            |:|.      ..|...:::|:||..|:.:.:|:.||..:||.|.|:|.|.||:. |.:.   :.|
 Worm   309 PHLKEYVDGFYLRDCEKVMDQLVEPMRFLKLDNKEFVALKACVLFNPVAPGLSN-HAVNLVLNAR 372

  Fly   434 HQILNNLEDYISDRQYESRGRFGEI-LLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLG 497
            .:|....|.|:...:.....|.|:: ..||..|..::..:.|.|.|.|:.|||.||.|::|::|.
 Worm   373 RKIFAAFEKYVRVNKPLETTRVGDLTFFILTPLSVLSKSISEDIMFTKVSGVARIDVLMEELILA 437

  Fly   498 ----GELADNPLPLS----PPNQSNDYQSPTHTGNMEGGNQVNSSLDSLATSG 542
                ||...:..|.|    .|:.|.|..||.....:......||..:|..|:|
 Worm   438 ETDYGEDRQDQTPCSIMNDTPSGSQDMCSPCPEDLLRTSTSSNSPTNSSLTAG 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	43/74 (58%)
		NR_LBD_HNF4_like	264..494	CDD:132729	79/257 (31%)
nhr-35	NP_001024365.1	NR_DBD_HNF4A	77..152	CDD:143518	43/74 (58%)
		NR_LBD	230..434	CDD:299703	70/207 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I2338
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.990