Protein Alignment Hnf4 and nhr-60

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_506930.1
• Gene: nhr-60 / 180059
• WormBaseID: WBGene00003650
• Length: 443
• Species: Caenorhabditis elegans
• Alignment Length: 423
• Identity: 98/423 - (23%)
• Similarity: 167/423 - (39%)
• Gaps: 103/423 - (24%)

  Fly   128 SSGSNNNNSMFSPN--NNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGC 190
            ||.|.:.:|:..|:  :..|........|...::..:.|: ||.|.|||:.|.|.||..:||:||
 Worm     4 SSSSISQDSLDLPSILSTFSADEPEDEPSPTAVKSTKPQR-PTECLICGNSANGHHYDVASCNGC 67

  Fly   191 KGFFRRSVRKNHQYTCRFARNCVVDKDKRN---QCRYCRLRKCFKAGMKKEAVQNERDRIS---- 248
            |.||||....:..:.|:...:| .|..||.   :||.||.:||...||...|::.:....|
 Worm    68 KTFFRRMCVSDRSFECKAKGDC-FDLTKRKVPLKCRACRHQKCISVGMNPLAMEVDEKAASSSNF 131

  Fly   249 ---CRRTSNDDPDPG-------NGLSVISLV-----KAEN--------ESRQSK-AGAAMEPNIN 289
               .:|..:.:||..       |.:.::..|     |.:|        |::..: ..:|..|:.|
 Worm   132 KKLVKRAQDLEPDDDCQVTAVVNKMQIVKPVDSIESKMQNITDMLVYLETKVERFRKSAYNPHWN 196

  Fly   290 EDLSNKQFASINDVCES---------------------------------------------MKQ 309
            |      |:.:..:.||                                             :||
 Worm   197 E------FSGLEYLLESECRIGFGDRFGPMPGWPLRRDQLGPPRLPKPPSPGKPRDSQHSQNIKQ 255

  Fly   310 ----QLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRH 370
                .|||.||:||....|:.|...|::.|.|     |:.|..:  ::|:....:..|..||..
 Worm   256 WFFYNLLTTVEYAKTFMFFHRLSSRDKLILTR-----HVALACT--NLHISYSSIRRNLEVIIE- 312

  Fly   371 CPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLN-EPHRIKSL-R 433
             ||.......:.:...|.::.  |..:....|.:.|:..:||:|..:|....|: :...|.|| |
 Worm   313 -PDGSEPMTFNDTHYSASVMS--VAPLIRCQIKNIEYLLLKAIVLCNPAVPDLSAKSQEIISLER 374

  Fly   434 HQILNNLEDYISDRQYESRGRFGEILLILPVLQ 466
            .:..:.|.:|....:.:....|.:::.|:.||:
 Worm   375 VKYADALFNYCLRSRSDGPPHFAQLIQIIDVLE 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	31/77 (40%)
		NR_LBD_HNF4_like	264..494	CDD:132729	52/268 (19%)
nhr-60	NP_506930.1	ZnF_C4	47..117	CDD:197701	30/70 (43%)
		HOLI	257..409	CDD:214658	39/162 (24%)