Protein Alignment Hnf4 and nhr-114

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001024242.1
• Gene: nhr-114 / 178821
• WormBaseID: WBGene00003704
• Length: 418
• Species: Caenorhabditis elegans
• Alignment Length: 413
• Identity: 105/413 - (25%)
• Similarity: 171/413 - (41%)
• Gaps: 87/413 - (21%)

  Fly   164 QQSPT-----VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCR 223
            |.||:     ||.:|.|.|:|.|||..||.|||.||||::.|..:|.|:|..||.|||..|..||
 Worm     4 QSSPSSSRDHVCLVCQDFASGYHYGVPSCVGCKTFFRRTIMKKQKYICQFEGNCPVDKTIRCACR 68

  Fly   224 YCRLRKCFKAGMKKEAVQNERDRI-----------SCRRTSNDDPDPGNG--------------- 262
            |||..||...||.:.|:|..||.|           ..:.||:...|.|..
 Worm    69 YCRFEKCLSVGMDRNALQQNRDPIGYTKRTRRPKKELKTTSDCSSDEGASTPPSVSPLQLSPPPI 133

  Fly   263 -------------------------------LSVISLVKAENESRQSKA----GAAME----PNI 288
                                           ||....:::.:|:..|||    .|.:|    |:.
 Worm   134 SPLLFQAAPLKPRRCILQTLAEREKCANDLRLSEYLPIRSLHEALCSKALLNDTAFLEKWGQPSE 198

  Fly   289 NEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAG--EHLLLGLSRR 351
            ...:.:.:|.:.:|.....::....|.|:||....|..|...|:..|:| ||.  ..:|:.:...
 Worm   199 RHQIFDLRFVNHDDYHYWHERDWFLLTEYAKTFDVFEALDYQDKAELVR-HAAITVPVLVQVWNS 262

  Fly   352 SMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFF 416
            ..:..|.::..:.....| .|:|.....|  :|...:::|.::...:|:.:|.||||..||:.|.
 Worm   263 PDYGPDTIVFPDGAYFDR-TPEPTRPAGL--NRKKYQMLDLVLKPFRDLQLDATEFAAFKAVTFL 324

  Fly   417 DPNAKGLNEPHR--IKSLRHQILNNLEDYIS-----DRQYESRGRFGEILLILPVLQSITWQMIE 474
            :|:| .::.|.|  :.:.|.:|...|..|::     |...|   ||..::|:...:..:..:..|
 Worm   325 NPDA-DISLPARKLVNNERVRITKQLYGYMAMKDDVDTAIE---RFARLVLMGTSMSKMACESKE 385

  Fly   475 QIQFAKIFGVAHIDSLLQEMLLG 497
            .:..|..|......:..:::..|
 Worm   386 AVWIADFFENIGFSAFARQLFFG 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	38/74 (51%)
		NR_LBD_HNF4_like	264..494	CDD:132729	54/246 (22%)
nhr-114	NP_001024242.1	NR_DBD_HNF4A	15..90	CDD:143518	38/74 (51%)
		HOLI	218..379	CDD:214658	41/168 (24%)