Protein Alignment Hnf4 and nhr-7

DIOPT Version :9

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_502117.2
• Gene: nhr-7 / 178035
• WormBaseID: WBGene00003606
• Length: 536
• Species: Caenorhabditis elegans
• Alignment Length: 629
• Identity: 129/629 - (20%)
• Similarity: 224/629 - (35%)
• Gaps: 206/629 - (32%)

  Fly   163 QQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRSVRK-NHQYTCRFARNCVVDKDKRNQCRYCR 226
            |..:..:||:|||.....|||..:|.||||||||:|:. .::|.|||.:||.|.|.:||.|||||
 Worm     2 QSYTNRICAVCGDTPAKIHYGVLACFGCKGFFRRAVKDGRNKYVCRFEKNCEVTKFERNACRYCR 66

  Fly   227 LRKCFKAGMKKEAVQNERDRI-------------------------------------------- 247
            .|||...||..:.|:.:|::.
 Worm    67 FRKCLLVGMNPDYVRPDREKSKKGKTVLSKKKSVSRSLSYRLADPSDWTSFLSPSSRKQLSEIGK 131

  Fly   248 ---SCRRTSNDDPDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDV--CESM 307
               :|..::|.| ..|| .|:.||:...:.:|::....||:.:.:....|:||..|..:  |...
 Worm   132 LAETCSTSTNFD-GIGN-FSLKSLIADRSLARKTGDSEAMDCSNSPRQLNEQFLGIERIVQCVDY 194

  Fly   308 KQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLL------GLSRRSMHLKDV-LLLSNNC 365
            ..:.|.::|...    ..:..::|:.||: :....||||      .:::.:..|:|: |.|:...
 Worm   195 IDRFLVMLEEEH----CRKFSVEDKSALI-SDTMIHLLLFESTSRFVAKGAPGLEDLKLSLAQLP 254

  Fly   366 VITRHCPDPLVSPNLDISRIGARIIDELVTVM-KDVGIDDTEFACIKALVFFDPNAKGLNEPHRI 429
            :.|.|              :..:|.|...|.: |...|  .|::.:||.:.....:..|:
 Worm   255 ICTTH--------------LTQKIADVFETYLRKPPSI--IEYSVLKAYIVLSAESTVLS----- 298

  Fly   430 KSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAH-IDSLLQE 493
                    |:|.:.:|    .:|....|:|          :::|:..:.......|: :.::|..
 Worm   299 --------NSLNESLS----LARENLSELL----------FKVIKHSRNKTSISAANSLSTILHF 341

  Fly   494 MLLGGELADNPLPLSPP--NQSNDYQSPTH-----------------TGNMEG-GNQVNSSLDSL 538
            :.....||........|  .:.:|.:.|.|                 |.|... ..|:.|||.|:
 Worm   342 VYESRNLASRIRQSQQPFFVRDSDPKIPFHKILTDIINPEVSDLLLTTANCRKLSTQMGSSLSSV 406

  Fly   539 ATSGGPGSHSLDLEVQHIQALIEANSADDSFRAYAASTAAAAAAAVSSSSSAPASVAPASISPPL 603
            .....|..                                    .|.....:|.|::|..||.|
 Worm   407 PPVPPPSD------------------------------------TVPLFHFSPPSLSPCQISAP- 434

  Fly   604 NSPKSQHQHQQHATHQQQQESSYLDMPVKHYNGSRSGPLPTQHSPQRMHPYQRAVASPVEVSSGG 668
                         ...|||.:.|..||......:.|.|..:.:.|..:..:.:.   |:|::.
 Worm   435 -------------PPPQQQYTDYSQMPSTSSYPANSSPFQSPYRPNSLSSFPKI---PLEMTK-- 481

  Fly   669 GGLGLRNPADITLNEYNRSEGSSAEEL-----------LRRTPL 701
                       ::.|:.|..|.:.:|:           .|.||:
 Worm   482 -----------SIEEFLRPNGMTTDEMNKPLEKNWADGFRLTPV 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	39/75 (52%)
		NR_LBD_HNF4_like	264..494	CDD:132729	44/240 (18%)
nhr-7	NP_502117.2	NR_DBD_HNF4A	9..85	CDD:143518	39/75 (52%)
		NR_LBD	188..339	CDD:299703	33/198 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910