Protein Alignment Hnf4 and nhr-34

DIOPT Version :9

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001023245.1
• Gene: nhr-34 / 177800
• WormBaseID: WBGene00003627
• Length: 631
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 150/634 - (23%)
• Similarity: 243/634 - (38%)
• Gaps: 164/634 - (25%)

  Fly    41 EAGRRRRRRDSSASRTASSDESESHIMHADALASAYPAASQPH-SPIGLALSPNGGGLGLSNSSN 104
            |.|....:.....|...|...|.:| ...::.:...||..:|. ||..|...|    |.|:::.:
 Worm    19 ETGNEDVQECIDKSPNGSPTTSTTH-RRQNSSSGLEPARKRPKLSPPVLTAMP----LDLTDAVS 78

  Fly   105 QSSENFALCNGNGNAGSAGGGSASSGSNNNNSMFSP-----NNNLSGSGSGTNSSQQQLQQQQQQ 164
            .:.......:..|...:||....|......:|..:|     ..::......|......:.....|
 Worm    79 PNESQACTSSLKGVVTAAGAAQMSVADRMTSSSVAPPLCIVPRSVEFINPKTEDMSMDIPMGNVQ 143

  Fly   165 QSPT--VCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRL 227
            ...|  .|.:|||...|:|||..:|:|||||||||:.:...|.|||...|:|.::.||:||.|||
 Worm   144 SEFTGLKCRVCGDSRAGRHYGTIACNGCKGFFRRSIWEQRDYVCRFGGKCLVVQEYRNRCRACRL 208

  Fly   228 RKCFKAGMKKEAVQNERDR------------------------ISCRRTS------------NDD 256
            ||||..||...|||:|||:                        ||...||            |..
 Worm   209 RKCFTVGMDARAVQSERDKHKKNPKDSNNEGSTSPQYPTASTPISIPSTSTSQTPTSSVNSYNFQ 273

  Fly   257 PDPGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFAS------------INDVCESMK- 308
            ..||    ::|...:||...:..:...||.:.:..||:.....            |::.|:.|.
 Worm   274 NIPG----IVSRSFSENLIMRDNSVPVMETSQSAALSHVPLVRYLIDLEKATDNLIDENCDFMSM 334

  Fly   309 ---------------------------------QQLLTL--------------VEWAKQIPAFNE 326
                                             ::|.||              :::||.:..:.|
 Worm   335 EFDQLCRVDVTIEAAFRQPGVVAKRTPPRWLALERLTTLEDVHIAWCRSFVLCIDYAKIMKDYQE 399

  Fly   327 LQLDDQVALLR---------AHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLD- 381
            |...||..|||         .|..:....|.        |.:.|.|.....|   |..:...||
 Worm   400 LSPTDQFTLLRNRVISVNWLCHTYKTFKAGC--------DGVALVNGSWYPR---DKELQKQLDP 453

  Fly   382 -----ISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHR--IKSLRHQILNN 439
                 ...:...::::||..|:::.:|:.||..:|||:.|..:.: |:|..|  ||.:|.:.:..
 Worm   454 GCNHYFRILSEHLMEDLVIPMREMDMDEGEFVILKALILFRAHRR-LSEEGRAHIKRVRDKYIEA 517

  Fly   440 LEDYISDRQYESRG--------RFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLL 496
            |..::   |::.|.        |..:|||:||.::.::.|..:.:||..:|.:|:::.|..|:
 Worm   518 LYQHV---QHQHRHFSSVQTSMRISKILLLLPSIEHLSQQEDDNVQFLALFNLANLNGLPYEL-- 577

  Fly   497 GGELADNPLPLSPPN--QSNDYQSPTHTGNMEGGNQVNSS--LDSLATS 541
                 .:.:....||  .|:|.|....|.|.:|.....||  ..|::||
 Worm   578 -----HSSIKQHIPNGDDSDDTQVNEVTSNNDGPRSSESSHTPQSVSTS 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	41/74 (55%)
		NR_LBD_HNF4_like	264..494	CDD:132729	62/314 (20%)
nhr-34	NP_001023245.1	NR_DBD_HNF4A	151..226	CDD:143518	41/74 (55%)
		HOLI	380..551	CDD:214658	43/185 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010