Protein Alignment Hnf4 and nhr-46

DIOPT Version :9

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001023065.1
• Gene: nhr-46 / 177350
• WormBaseID: WBGene00003636
• Length: 576
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 117/522 - (22%)
• Similarity: 169/522 - (32%)
• Gaps: 169/522 - (32%)

  Fly    78 AASQPHSPIGLALSPNG-----------GGLGLSNSSNQSSENFALC-NGNGNAG---SAGGGSA 127
            :||.|:.|:.|:.....           ....|:...||.:.||.:. ..||..|   ......|
 Worm    60 SASPPNLPMFLSFPSTSTTTSILMDTVLAAQKLNQQQNQQAFNFMVVKQENGETGRNFMTMKQDA 124

  Fly   128 SSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICG-DRATGKHYGASSCDGCK 191
            .....|..|..||.|.:.|..                     |..|| :.|...|||||||.|||
 Worm   125 LQAITNTVSRNSPPNVIKGER---------------------CVGCGSESAIRVHYGASSCHGCK 168

  Fly   192 GFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDD 256
            .||||||.:...|.|....:|.:..:.||:||.||||.|.:.||..:.|:.||.:|        :
 Worm   169 AFFRRSVFEGRVYMCSADNHCDITNESRNRCRACRLRNCLEGGMNPKHVREERSKI--------E 225

  Fly   257 PDPGNGLSVISLVKAENESRQSKAGAAMEP---------NINEDLSNKQFAS------------- 299
            ..|||..:    |.|.|....|.:.|:..|         .|....|...|:|
 Worm   226 RMPGNTCT----VSAANGVSHSSSAASASPEHKFSFSLSTIAPSTSTGSFSSGSQPAPIESTNSS 286

  Fly   300 -------------------------------------INDV------------------------ 303
                                                 .|||
 Worm   287 GSEAEVLDRKLIQENQLTLFMVALEKQTEQLTDDDVKDNDVMGAWSRDITLTFGLQHPQMVIKRL 351

  Fly   304 -----CE----------SMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSM 353
                 |:          |..:..:...:||..||.|..|.|.||..|.:.:......:..:.:..
 Worm   352 PLKYSCDRIMEAADLYLSWYRSFVFAADWAMGIPEFRVLPLADQTTLFKQNFMAFGWITFAYKCF 416

  Fly   354 HLKDVLL---LSNNCVITRHCPDPLVSPNLDISRIGA---RIIDELVTVMKDVGIDDTEFACIKA 412
            .||..|.   |.|...|..:..|....|.......|.   ::||.:|..|.::.|.:.|:..||.
 Worm   417 ELKQHLTGMPLGNGAYIPYNDEDQKKLPERWAQTYGVVCRKLIDLIVKAMIELQITEEEYCLIKT 481

  Fly   413 LVFFDPN------AKGLNEPHRIKSLRHQILNNLEDYISDR-QYESRG----RFGEILLILPVLQ 466
            :..|..:      .:|:     ...:|.::|:.|..:|..| .|.:..    |..:|.|:||...
 Worm   482 ISLFQQDCILSEAGQGI-----CSRMRDRLLDALSAHIEKRYPYHTTSQRMTRALKISLMLPSFS 541

  Fly   467 SI 468
            .|
 Worm   542 HI 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	36/75 (48%)
		NR_LBD_HNF4_like	264..494	CDD:132729	56/320 (18%)
nhr-46	NP_001023065.1	ZnF_C4	146..215	CDD:197701	34/68 (50%)
		NR_LBD	365..540	CDD:132726	41/179 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910