DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and Hnf4a

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_032287.2	Gene:	Hnf4a / 15378	MGIID:	109128	Length:	474	Species:	Mus musculus

Alignment Length:	459	Identity:	249/459 - (54%)
Similarity:	310/459 - (67%)	Gaps:	56/459 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SASSGSNNNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGC 190
            |.|.|:|.|:|     |:|..|                    .:|||||||||||||||||||||
Mouse    41 SPSEGANLNSS-----NSLGVS--------------------ALCAICGDRATGKHYGASSCDGC 80

  Fly   191 KGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSND 255
            ||||||||||||.|:|||:|.||||||||||||||||:|||:||||||||||||||||.||:|.:
Mouse    81 KGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYE 145

  Fly   256 DPD-PGNGLSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAK 319
            |.. |    |:.:|::||..|:|..:..:   .||.|:..|:.|:|.|||||||:|||.||||||
Mouse   146 DSSLP----SINALLQAEVLSQQITSPIS---GINGDIRAKKIANITDVCESMKEQLLVLVEWAK 203

  Fly   320 QIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISR 384
            .||||.||.|||||||||||||||||||.::|||..||||||.|:.::.||||:     ..::||
Mouse   204 YIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPE-----LAEMSR 263

  Fly   385 IGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQY 449
            :..||:||||...:::.|||.|:||:||::||||:||||::|.:||.||.|:..:|||||:||||
Mouse   264 VSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQY 328

  Fly   450 ESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSP--PNQ 512
            :|||||||:||:||.||||||||||||||.|:||:|.||:|||||||||..:|.|....|  |:.
Mouse   329 DSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHTHHPLHPHL 393

  Fly   513 SNDYQS---------PTHTGNME-------GGNQVNSSLDSLATSGGPGSHSLDLEVQHIQALIE 561
            ..::..         |:|..|.:       .|..........:...|.||.|..|....|..:::
Mouse   394 MQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVK 458

  Fly   562 ANSA 565
            ..||
Mouse   459 PPSA 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	68/74 (92%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	140/229 (61%)
Hnf4a	NP_032287.2	NR_DBD_HNF4A	60..135	CDD:143518	68/74 (92%)
		NR_LBD_HNF4_like	151..373	CDD:132729	140/229 (61%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P41235	368..376		6/7 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..450		7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2052
eggNOG	1	0.900	-	-		E1_KOG4215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1590
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm44360
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850