Protein Alignment Hnf4 and Eip75B

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_061517599.1
• Gene: Eip75B / 1280470
• VectorBaseID: AGAMI1_012295
• Length: 1448
• Species: Anopheles gambiae
• Alignment Length: 854
• Identity: 199/854 - (23%)
• Similarity: 297/854 - (34%)
• Gaps: 242/854 - (28%)

  Fly    43 GRRRRRRDSSASRTASSDESESHIMHADALASAYPAASQPHSPIGLALSPNGG-GLGLSNSSNQS 106
            ||..:.:.......|..:|......|............|.||.|.:|   ||| ...||:....|
Mosquito   210 GRFYQPQQQQRHEEAMVEEEPEDAPHGQYHVPLQQQQQQQHSSIIVA---NGGRSSPLSHQGRLS 271

  Fly   107 SENFALCNGNGNAGSAGGGSA------SSG---------SNNNNSMFSPNNNLSGSGSGTNSSQQ 156
            .           |||..||:|      ||.         ||...|::.|....:.:.:.|.||.:
Mosquito   272 P-----------AGSGCGGAAVQHPHTSSSITTTTTILVSNERASIYKPPTQATSTTTTTVSSSK 325

  Fly   157 QLQQQ----QQQQSP-----------------------------------TVCAICGDRATGKHY 182
            |.||.    ..|..|                                   .:|.:|||:|:|.||
Mosquito   326 QQQQHGHVTSMQPPPPPPPLKMSKGGSGGSGGGHEEPSSSMPDLEFDGTTVLCRVCGDKASGFHY 390

  Fly   183 GASSCDGCKGFFRRSVRKNHQY-TCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAV------ 240
            |..||:|||||||||:::..|| .|...:.|.:.:..||:|:||||:||...||.::||
Mosquito   391 GVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVP 455

  Fly   241 QNERDRI------SCRRTSND-------DPDPGNGLSVISLVKAENESRQSKAGAAME------- 285
            :.|:.||      |.:...|.       |..|....||:.......|..:.|..|..:
Mosquito   456 KREKARILAAMQQSTQNRGNQRALASELDDQPRLLASVLQAHIETCEFTREKVAAMRQRARDCPS 520

  Fly   286 -------------PNI-NEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALL 336
                         |.: :|...:::||.:          :..::::|..||.|..|..||:..||
Mosquito   521 YSMPTLACPLNPAPELQSEQEFSQRFAHV----------IRGVIDFAGMIPGFQLLTQDDKFTLL 575

  Fly   337 RAHAGEHLLLGL-SRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGAR---IIDELVTV- 396
            :|...:.|.:.| ......:..::.| |..|:.|           |..:.||.   ::|.....
Mosquito   576 KAGLFDALFVRLICMFDTSINSIICL-NGQVMRR-----------DTIQNGANARFLVDSTFNFA 628

  Fly   397 --MKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEIL 459
              |..:.:.|.|.....|:|...|:..||.....|:.:..::...|:..||..:.:......|:|
Mosquito   629 ERMNSMQLTDAEIGLFCAIVLITPDRPGLRNVELIERMYTKLKACLQSVISQNRPDKPEFMQELL 693

  Fly   460 LILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPL---SPPNQSNDYQSPTH 521
            ..:|.|::::....|::   .:|...|.:.|.|:|....|  |....|   ||.:.|.|
Mosquito   694 RTMPDLRTLSTLHTEKL---VVFRTEHKELLRQQMWSAEE--DQGAVLDAKSPASWSCD------ 747

  Fly   522 TGNMEGGNQVN-----------SSLDSLAT--SGGPGSHSLDLEVQHIQALIEANSADDSFRAYA 573
                  ||||.           ||.:|..|  |....|.||..|..|:......:....|    |
Mosquito   748 ------GNQVEVEIAKSPMSSVSSTESTETSSSSSSSSSSLSSEYHHLHHHHHQHGGISS----A 802

  Fly   574 ASTAAAAAAAV---------------------------------------------SSSSSAPAS 593
            ||.||...||.                                             |||||:.:|
Mosquito   803 ASAAAPLLAATLSGACPIIRHRASSGSSAEDDLIGGTAQHLAQNGLTITPVIRSVGSSSSSSASS 867

  Fly   594 VAPASISPPLNSPKSQHQHQQHATHQQQQESSYLDMPVKHYNGSRSGPLPTQ-----HSPQRMHP 653
            .:.:|.|....:....|.|..|...:.::..|..|..::..|.....|.|.|     |..|..|.
Mosquito   868 ASSSSASSGAGASHLHHHHHHHHVSRYRKLDSPTDSGIESGNEKHDNPSPQQQQQQLHHQQHHHL 932

  Fly   654 YQRAVASPVEVSSGGGGL-----GLRNPADITLNEYNRSEGSSAEELLRRT-----PLKIRAPEM 708
            ......:...||||....     .|.:||   |.:.:.|....|..|.|..     |:..|   :
Mosquito   933 LLHPKPASSSVSSGSSSCSSPRSSLEDPA---LEDSSSSSNGKAPSLARHASVDNMPVLKR---V 991

  Fly   709 LTAPAGYGT 717
            |.||..|.|
Mosquito   992 LQAPPLYDT 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	38/81 (47%)
		NR_LBD_HNF4_like	264..494	CDD:132729	50/257 (19%)
Eip75B	XP_061517599.1	None