Protein Alignment Hnf4 and rxra

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_012824678.1
• Gene: rxra / 100487877
• XenbaseID: XB-GENE-478718
• Length: 498
• Species: Xenopus tropicalis
• Alignment Length: 478
• Identity: 159/478 - (33%)
• Similarity: 240/478 - (50%)
• Gaps: 91/478 - (19%)

  Fly    96 GLGLSNSSNQSSENFALCNGNGNAGSAGGGSASSGSNNN----NSMFSPNNNLS----------- 145
            |...|...|.||.|.:...|:..|........:||.||:    ..:.||.|.:.
 Frog    27 GYDFSTQVNASSLNSSGLRGSMTAPLLHPSLGNSGINNSLGSPTQLHSPLNGMGPPFSVISPPLG 91

  Fly   146 ---------GSGSGTNSSQ-----QQLQQQQQQQSPT----------------------VCAICG 174
                     |.|.||.|.|     ..:...:..:.|.                      :|||||
 Frog    92 PSMPIPSTPGLGFGTGSPQIHSPMNSVSSTEDIKPPPGINGILKVPAHPSGPMASFTKHICAICG 156

  Fly   175 DRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKE- 238
            ||::|||||..||:||||||:|:|||:..||||.:::|::||.:||:|:|||.:||...|||:|
 Frog   157 DRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDSKDCMIDKRQRNRCQYCRYQKCLAMGMKREG 221

  Fly   239 ------------------AVQNERDR--------ISCRRTSNDDPDPGNGLSVISLVKAENESRQ 277
                              |||.||.|        :....::|:|......|.....|:.:.|: .
 Frog   222 MEHHPSQHSRDLRCQAEQAVQEERQRGKERNENEVESSSSANEDMPVEKILDAEHAVEPKTET-Y 285

  Fly   278 SKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGE 342
            .:|...:.||...|       .:.::|::..:||.|||||||:||.|:||.|||||.||||...|
 Frog   286 IEANMGLAPNSPSD-------PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNE 343

  Fly   343 HLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEF 407
            .|:...|.||:.:||.:||:....:.|:.     :.:..:..|..|::.|||:.|:|:.:|.||.
 Frog   344 LLIASFSHRSIAVKDGILLATGLHVHRNS-----AHSAGVGAIFDRVLTELVSKMRDMQMDKTEL 403

  Fly   408 ACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQM 472
            .|::|:|.|:|::|||:.|..:::||.::..:||.|...:..|..|||.::||.||.|:||..:.
 Frog   404 GCLRAIVLFNPDSKGLSNPSEVEALREKVYASLEAYCKQKYPEQPGRFAKLLLRLPALRSIGLKC 468

  Fly   473 IEQIQFAKIFGVAHIDSLLQEML 495
            :|.:.|.|:.|...||:.|.|||
 Frog   469 LEHLFFFKLIGDTPIDTFLMEML 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	47/93 (51%)
		NR_LBD_HNF4_like	264..494	CDD:132729	82/229 (36%)
rxra	XP_012824678.1	Nuc_recep-AF1	37..144	CDD:463363	19/106 (18%)
		NR_DBD_RXR	150..245	CDD:143514	46/94 (49%)
		NR_LBD_RXR_like	265..476	CDD:132741	79/223 (35%)