DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hnf4 and hnf4b

DIOPT Version :9

Sequence 1:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_002936047.1	Gene:	hnf4b / 100486037	XenbaseID:	XB-GENE-485826	Length:	458	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	244/450 - (54%)
Similarity:	303/450 - (67%)	Gaps:	70/450 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAG 234
            |||||||||||||||||||||||||||||||||.|.|||:|.|:||||||||||||||||||:||
Frog    59 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHVYACRFSRQCIVDKDKRNQCRYCRLRKCFRAG 123

  Fly   235 MKKEAVQNERDRISCRRTSNDDPDPGNG-LSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFA 298
            ||||||||||||||.||:|.:|    || ||:..|.:||....|.   :.:.|..:.|:|.|:.|
Frog   124 MKKEAVQNERDRISMRRSSYED----NGSLSISVLTQAEAMVLQY---SPLSPAHSSDISMKKVA 181

  Fly   299 SINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSN 363
            ||:|||||||||||.||||||.||||.||.|||||||||||||.|||||:::||:..||.|||.|
Frog   182 SISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSLPYKDFLLLGN 246

  Fly   364 NCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHR 428
            :.::..|||:      |:::|:..||:||||..::::.|||.|:||:||::||||:.|||::..:
Frog   247 DFIMPMHCPE------LEVARVACRILDELVKPLREIQIDDNEYACLKAIIFFDPDCKGLSDQTK 305

  Fly   429 IKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQE 493
            :|::|.|:..||||||:||||:|||||.:|||:||.|||||||||||:||||:||||.|||||||
Frog   306 VKNMRFQVQVNLEDYINDRQYDSRGRFSDILLLLPPLQSITWQMIEQVQFAKLFGVARIDSLLQE 370

  Fly   494 MLLGGELADNPLPLSPPNQSNDYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSLDL-EVQHIQ 557
            |||||...|          .:.|....|:|         .:||.|:   ||..|..:| .|.|
Frog   371 MLLGGSAMD----------GSQYSHSGHSG---------LNLDLLS---GPTVHPHNLHSVIH-- 411

  Fly   558 ALIEANSADDSFRAYAASTAAAAAAAVSSSSSAPASVAPASISPPLNSPKSQHQHQQHAT 617
                                       :.|||:|.:..|:    |..:|.|:......||
Frog   412 ---------------------------TVSSSSPETSLPS----PSTNPNSEDYKMNTAT 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	68/74 (92%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	135/229 (59%)
hnf4b	XP_002936047.1	NR_DBD_HNF4A	59..134	CDD:143518	68/74 (92%)
hnf4b	XP_002936047.1	NR_LBD_HNF4_like	150..371	CDD:132729	135/229 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1997
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H128571
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1550
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm49535
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.080