Protein Alignment Hnf4 and hnf4b

DIOPT Version :10

• Sequence 1: NP_723413.1
• Gene: Hnf4 / 44544
• FlyBaseID: FBgn0004914
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_002936047.1
• Gene: hnf4b / 100486037
• XenbaseID: XB-GENE-485826
• Length: 458
• Species: Xenopus tropicalis
• Alignment Length: 450
• Identity: 244/450 - (54%)
• Similarity: 303/450 - (67%)
• Gaps: 70/450 - (15%)

  Fly   170 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAG 234
            |||||||||||||||||||||||||||||||||.|.|||:|.|:||||||||||||||||||:||
 Frog    59 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHVYACRFSRQCIVDKDKRNQCRYCRLRKCFRAG 123

  Fly   235 MKKEAVQNERDRISCRRTSNDDPDPGNG-LSVISLVKAENESRQSKAGAAMEPNINEDLSNKQFA 298
            ||||||||||||||.||:|.:|    || ||:..|.:||....|.   :.:.|..:.|:|.|:.|
 Frog   124 MKKEAVQNERDRISMRRSSYED----NGSLSISVLTQAEAMVLQY---SPLSPAHSSDISMKKVA 181

  Fly   299 SINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSN 363
            ||:|||||||||||.||||||.||||.||.|||||||||||||.|||||:::||:..||.|||.|
 Frog   182 SISDVCESMKQQLLLLVEWAKYIPAFCELPLDDQVALLRAHAGAHLLLGVAKRSLPYKDFLLLGN 246

  Fly   364 NCVITRHCPDPLVSPNLDISRIGARIIDELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHR 428
            :.::..|||:      |:::|:..||:||||..::::.|||.|:||:||::||||:.|||::..:
 Frog   247 DFIMPMHCPE------LEVARVACRILDELVKPLREIQIDDNEYACLKAIIFFDPDCKGLSDQTK 305

  Fly   429 IKSLRHQILNNLEDYISDRQYESRGRFGEILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQE 493
            :|::|.|:..||||||:||||:|||||.:|||:||.|||||||||||:||||:||||.|||||||
 Frog   306 VKNMRFQVQVNLEDYINDRQYDSRGRFSDILLLLPPLQSITWQMIEQVQFAKLFGVARIDSLLQE 370

  Fly   494 MLLGGELADNPLPLSPPNQSNDYQSPTHTGNMEGGNQVNSSLDSLATSGGPGSHSLDL-EVQHIQ 557
            |||||...|          .:.|....|:|         .:||.|:   ||..|..:| .|.|
 Frog   371 MLLGGSAMD----------GSQYSHSGHSG---------LNLDLLS---GPTVHPHNLHSVIH-- 411

  Fly   558 ALIEANSADDSFRAYAASTAAAAAAAVSSSSSAPASVAPASISPPLNSPKSQHQHQQHAT 617
                                       :.|||:|.:..|:    |..:|.|:......||
 Frog   412 ---------------------------TVSSSSPETSLPS----PSTNPNSEDYKMNTAT 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	68/74 (92%)
		NR_LBD_HNF4_like	264..494	CDD:132729	135/229 (59%)
hnf4b	XP_002936047.1	NR_DBD_HNF4A	59..134	CDD:143518	68/74 (92%)
		NR_LBD_HNF4_like	150..371	CDD:132729	135/229 (59%)