DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and R3hdm2

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	NP_001161764.1	Gene:	R3hdm2 / 71750	MGIID:	1919000	Length:	1044	Species:	Mus musculus

Alignment Length:	956	Identity:	239/956 - (25%)
Similarity:	359/956 - (37%)	Gaps:	239/956 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |.:||::|||..|.||..|..:||.|||:||.:|||:|::::||:.:|:...: :||..:||:||
Mouse   139 SRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINDNNNQFK-KFPQMTSYHRM 202

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFDE 543
            |:||.||:|||:|||| :|.:.||:....:|||||.||...::|:     .::.|||||..|.|.
Mouse   203 LLHRVAAYFGMDHNVD-QTGKAVIINKTSSTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDR 266

  Fly   544 VRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSR-TGGN---------HDGYSGGG------- 591
             ..:....||...|::||.|||||:|.|.|.|||:| ||.|         .:.:|...
Mouse   267 -DDNQMRVPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRLSKEAFSSSSHKRRQIF 330

  Fly   592 -GDEECYGGWEQQQQQQKQSQ----PPRPKRPNGKMLQMQNSTESRDGMRS-GGAVPKSHNFGNY 650
             |:.|........:|....|:    .|||          .:||:|...:|| ...|.|:.:|.
Mouse   331 RGNREGLSRTSSSRQSSTDSELKSLEPRP----------WSSTDSDGSVRSMRPPVTKASSFS-- 383

  Fly   651 GGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLS--------PSSSGYKTRTQSV 707
                     |.:.|.||||..|.|.|..|            |||        |......|..|||
Mouse   384 ---------GISILTRGDSIGSSKGGSAG------------RLSRPGMALGAPEVCNQVTSPQSV 427

  Fly   708 RSDSVTPSPTGYGSDRQTPELNHPSMMSHSRVAPPMSSGGGGVVGGGGSGAVTVSSVEMGTEATG 772
            |  .:.|........:|..:...|::....:..||:::                ..:.....|..
Mouse   428 R--GLLPCTAQQQQQQQQQQQQLPALPPTPQHQPPLNN----------------HMISQPVPALQ 474

  Fly   773 ADPSSTSNCSSGTSGIVWAVT---------DISNVPIGSLLIDPQTLQPIVNADGSIYHYDPSNL 828
            ..|.......|....::..|:         |:|| |.|.:.:..|         ||....|||:.
Mouse   475 PSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSN-PFGQMSLSRQ---------GSTEAADPSSA 529

  Fly   829 ---PPNQALQHSGNQYQSQNQGNSSSGGY----NNYRKSSPHQQQQSQQQQQSQQHHQQQLQ--- 883
               ||      ..:|:..|.....:|.|.    :||..||.....|.....|......||:|
Mouse   530 LFQPP------LISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSY 588

  Fly   884 QPQQLHQQSSQQYATTELSCSSTESYAEEE-------AQSPGME--CSEGYESYEQQSLPVQQQL 939
            .|...:..|:|||.    ..|...:|:.:.       :|.||::  .|...::..|..|.|||..
Mouse   589 YPPGQYPNSNQQYR----PLSHPVAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQ 649

  Fly   940 SGN--GDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLE 1002
            :..  .:..|:.|.....|        :...|...:| ::.|.........|:......|.....
Mouse   650 NQGLLSNQRSSMGGQMQGL--------VVQYTPLPSY-QVPVGSDSQNVVQPSFQQPMLVPASQS 705

  Fly  1003 LEAGLPQ--EQEQEPMAGPSSSGSATSSVGITELPSS------QTPLP-MVNQVNCDLQSVSPST 1058
            ::.|||.  ......|..|:.....:.|||..:.|.|      |:|.| ...|::.....||||.
Mouse   706 VQGGLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQMSQQYSGVSPSG 770

  Fly  1059 TPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQ------------APDGSTVFHTTTTPNGA 1111
            ......::..|:...||    :.|....|::.:.|.            :||||.   ......|:
Mouse   771 PGVVVMQLNVPNGPQAP----QNPSMVQWSHCKYYSVEQRGQKPGDLYSPDGSP---QANAQMGS 828

  Fly  1112 APYCATTYQQGPD--GSIYAVPQGM----VYAAYPQPGVGTAGG------ASQPLFQLTTSSHPP 1164
            :|..:.|....|.  .|:..|..|:    |...:|:|| |.|.|      ..||| |...|..||
Mouse   829 SPVTSPTQSPAPSPVTSLSNVCTGLSPLPVLTPFPRPG-GPAQGDGRYSLLGQPL-QYNLSICPP 891

  Fly  1165 AQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPG--------------AT 1215
                                             |:..|:.|....|..|              |:
Mouse   892 ---------------------------------LLHGQSTYTVHQGQSGLKHGNRGKRQALKSAS 923

  Fly  1216 TVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQL 1261
            |.:..|........: .|..|.|....:|..:::.....||::|.|
Mouse   924 TDLGTADVVLGRVLE-VTDLPEGITRTEADKLFTQLAMSGAKIQWL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	29/59 (49%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	23/55 (42%)
R3hdm2	NP_001161764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..147		3/7 (43%)
		R3H_encore_like	168..229	CDD:100071	30/62 (48%)
		SUZ	250..303	CDD:372290	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..288		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..408		29/120 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..485		6/67 (9%)
		Med15	451..>800	CDD:312941	79/397 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..533		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..600		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..770		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..848		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10397
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm44068
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8676
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.990