DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and Arpp21

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	XP_006244034.1	Gene:	Arpp21 / 363153	RGDID:	1593239	Length:	844	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	234/889 - (26%)
Similarity:	343/889 - (38%)	Gaps:	264/889 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |::.|::|||..|.||..|..:||..|.:||.||||:|:::|||:.:::...: :||..|||.||
  Rat   133 SKDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEMIDFIADSNNHYK-KFPQMSSYQRM 196

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFD- 542
            |:||.||:||::|||| :|.:.||:....:|||||.||...::|:     .::.|||||..|.|
  Rat   197 LVHRVAAYFGLDHNVD-QTGKSVIINKTSSTRIPEQRFCEHLKDEKSEESQKRFILKRDNSSIDK 260

  Fly   543 EVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQQQQ 607
            |..|...:.|...||::||.|||||:|.|.|.|||:     ||...   ..|..:....:.|:..
  Rat   261 EDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFA-----HDSVC---SQESLFLDNSRLQEDM 317

  Fly   608 -------KQSQPPRPKRPNGKML----QMQNSTESR--DGMRSGGA-------------VPKSHN 646
                   |:.|..|..|.:....    |..:.||.|  |..|:..:             :.|:.:
  Rat   318 HICNETYKKRQLFRAHRDSSGRTSGSRQSSSETELRWPDHQRAWSSTDSDSSNRNLKPTMTKTAS 382

  Fly   647 FGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGYKTRTQSVRSDS 711
            ||           |...|.|||||:|.:|..    |...|||.    |.||:|
  Rat   383 FG-----------GITVLTRGDSTSSTRSAG----KLSKTGSE----SSSSAG------------ 416

  Fly   712 VTPSPTGYGSDRQTPELNHPSMMSHSRVAPPMSSGG-GGVVGGGGSGAVTVSSVEMGTEATGADP 775
                                |..|.||..||:.|.. ...|..|..|.:..|...||.:   ..|
  Rat   417 --------------------SSGSLSRTHPPLQSTALTSSVAAGSPGCMAYSENGMGGQ---VPP 458

  Fly   776 SSTSNCSSGTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYDPSNLPPNQALQHSGNQ 840
            ||||.       |:..:...:.:|.||:|::|.|.||.||.||:...|:|           .|:|
  Rat   459 SSTSY-------ILLPLESATGIPPGSILLNPHTGQPFVNPDGTPAIYNP-----------PGSQ 505

  Fly   841 YQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSS 905
               |....:.||     :...|..||.|.|.||..|..|.|:..|  |..||.|
  Rat   506 ---QTLRGTVSG-----QPQQPPPQQPSPQPQQQVQASQPQMTGP--LVTQSVQ----------- 549

  Fly   906 TESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITTSTS 970
                        |::.|.....|...|.|.|..|.                .|.|....:....:
  Rat   550 ------------GLQPSSQSVQYPAVSFPPQHLLP----------------VSPTQHFPLREEMA 586

  Fly   971 TKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELP 1035
            .: :.::.:.:..:..|                         .||.:||....|.        :.
  Rat   587 AQ-FSQLSMSRQSSGDT-------------------------PEPPSGPVYPASL--------MQ 617

  Fly  1036 SSQTPLPMVNQVNCDLQS--VSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDG 1098
            ::|.|..::......|.:  .|.|..|.||..::.|.   :|...|::|.....:.   |..|.|
  Rat   618 AAQPPSYVITSAGQQLSTGGFSDSGPPISQQVLQAPP---SPQGFVQQPPPAQMSV---YYYPSG 676

  Fly  1099 STVFHTTTT----PNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTT 1159
            .  :.|:||    |..:..|.|...||        :||....|.| || |.:...:.|.|..:..
  Rat   677 Q--YPTSTTQQYRPLASVQYSAQRSQQ--------IPQTAQQAGY-QP-VLSGQQSFQGLMGVQQ 729

  Fly  1160 SSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPREGLIPAQAIYQTGPGGPGATTVMPMATAA 1224
            |:|  :|.:.:| :.||.:.|  .|:.            .|..:.||.
  Rat   730 SAH--SQGVMSS-QQGAPVHG--VMVS------------YPTMSSYQV----------------- 760

  Fly  1225 AYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPI 1268
              |..|.:.|.|.  ..||.|::..|:.|.|:    ||....|:
  Rat   761 --PMTQGSQAVPQ--QTYQPPIMLPSQTGQGS----LPATGMPV 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	30/59 (51%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	25/56 (45%)
Arpp21	XP_006244034.1	R3H_encore_like	162..223	CDD:100071	31/62 (50%)
		SUZ	244..299	CDD:403836	26/59 (44%)
		Med15	553..>790	CDD:312941	67/346 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348837
Domainoid	1	1.000	61	1.000	Domainoid score	I10183
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm46157
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15672
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930