Protein Alignment enc and R3HDM1

DIOPT Version :9

• Sequence 1: NP_001261376.1
• Gene: enc / 44543
• FlyBaseID: FBgn0004875
• Length: 1942
• Species: Drosophila melanogaster
• Sequence 2: NP_001365036.1
• Gene: R3HDM1 / 23518
• HGNCID: 9757
• Length: 1134
• Species: Homo sapiens
• Alignment Length: 1105
• Identity: 280/1105 - (25%)
• Similarity: 405/1105 - (36%)
• Gaps: 353/1105 - (31%)

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |.:||::|||..|.||..|..:||..||:||.:|||:|::::||: .|:.....:|||.:||:||
Human   138 SRDSSQEYTDSTGIDLHEFLVNTLKNNPRDRMMLLKLEQEILDFI-GNNESPRKKFPPMTSYHRM 201

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFDE 543
            |:||.||:||::|||| ::.:.|||....|||||:.:|...::||     .::.|||||..|||:
Human   202 LLHRVAAYFGLDHNVD-QSGKSVIVNKTSNTRIPDQKFNEHIKDDKGEDFQKRYILKRDNSSFDK 265

  Fly   544 ------VRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTG-GNHDGY--SGGGGDEECYGG 599
                  :|       |..||::||.|||||:|.|||.||||:.. .:.:.|  .....||:. ..
Human   266 DDNQMRIR-------LKDDRRSKSIEEREEEYQRARDRIFSQDSLCSQENYIIDKRLQDEDA-SS 322

  Fly   600 WEQQQQQQKQSQPPRPKRPNGKMLQMQN-----------STESRDGMRS-GGAVPKSHNFGNYGG 652
            .:|::|..:.::....:..|......:|           ||:|...:|: ..||.|:.:|.
Human   323 TQQRRQIFRVNKDASGRSTNSHQSSTENELKYSEPRPWSSTDSDSSLRNLKPAVTKASSFS---- 383

  Fly   653 PPSSGGPGNNSLPRGDSTNSIKS-GRGGFVKQDSTGSTPWRLSPSSSGYKTRTQSVRSDSVTPSP 716
                   |.:.|.||||:.|.|| ||......:|:||.     .||:|..:..|.       |.|
Human   384 -------GISVLTRGDSSGSSKSIGRLSKTGSESSGSV-----GSSTGSLSHIQQ-------PLP 429

  Fly   717 -TGYGSDRQTPELNHPSMMSHSRVAPPMSSGGGGVVGGGGSGAVTVSSVEMGTEATGADPSSTSN 780
             |..........:.:|::.:||.::          ..||.:|.|             |.||
Human   430 GTALSQSSHGAPVVYPTVSTHSSLS----------FDGGLNGQV-------------ASPS---- 467

  Fly   781 CSSGTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYDPSNLPPNQALQHSGNQYQSQN 845
                ||..:..: :.:.:|.||:||:|||.||.:|.|||...|:|   |..|      ...:||.
Human   468 ----TSFFLLPL-EAAGIPPGSILINPQTGQPFINPDGSPVVYNP---PMTQ------QPVRSQV 518

  Fly   846 QGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQ----LQQPQQLHQQSSQQYATTELSCSST 906
            .|             .|.....:..||.:..|...|    ||...|..|.|:..|.:..|..|.|
Human   519 PG-------------PPQPPLPAPPQQPAANHIFSQPVHPLQSSSQPVQYSTAPYPSPFLPVSPT 570

  Fly   907 ESYAEEE-----------AQSPGMECSEGYESYEQQSLPVQQ-QLSG------------------ 941
            :.|:.::           |:.|..:.|:.:.:..|.::.:|. |.||
Human   571 QQYSVQDNLGSQFSHMSLARQPSADGSDPHAAMFQSTVVLQSPQQSGYIMTAAPPPHPPPPPPPP 635

  Fly   942 -------NGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPAC-CAVG 998
                   .|....|.|              ...|....:...::.|.|..| .||.:||| ||.|
Human   636 PPPPPLPPGQPVPTAG--------------YPASGHPVSQPVLQQQGYIQQ-PSPQMPACYCAPG 685

  Fly   999 EKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQ 1063
                      .....:|...|..|....|.:        ..|||...|           .|.|.
Human   686 ----------HYHSSQPQYRPVPSVHYNSHL--------NQPLPQPAQ-----------QTGYQ- 720

  Fly  1064 CEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNGAAPYCATTYQQGPDGSIY 1128
             .:....||:.....|::|        ||.....|.        ||                ||.
Human   721 -VIPNQQQNYQGIVGVQQP--------QSQSLVSGQ--------PN----------------SIG 752

  Fly  1129 AVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQ 1193
            ...||:|   .|...|        |.:|::.            |:....||..||..||..| .|
Human   753 NQIQGVV---IPYTSV--------PTYQVSL------------PQGSQGIPHQTYQQPVMFP-NQ 793

  Fly  1194 PREGLIPAQAI---YQTGPGG--------------PGATTVMPMATAAAYPTAQF----ATAAPN 1237
            ..:|.:|...:   |...|.|              ||:..|....|.:...:.|.    .||.|
Human   794 SNQGSMPTTGMPVYYSVIPPGQQNNLSSSVGYLQHPGSEQVQFPRTTSPCSSQQLQGHQCTAGP- 857

  Fly  1238 GAPIYQAPLIYSSEPGGGAQLQQL--PMAPYPIQYSYPYYHPISYYVPQQA-------VAAAPMV 1293
                       ...||||..:.||  |..|....:|.|.:....||...|.       .:...:|
Human   858 -----------PPPPGGGMVMMQLSVPNNPQSCAHSPPQWKQNKYYCDHQRGQKCVEFSSVDNIV 911

  Fly  1294 ASQPQVGQ---APMQQQAPHTGAGTTT----GPPTVVSVSGQQHHQPHQQHHQQQQHSSNGSVVT 1351
            ...||:..   :|.|..||...:...|    |||..:.   .|..:|.
Human   912 QHSPQLSSPIISPAQSPAPAQLSTLKTVRPSGPPLSIM---PQFSRPF----------------- 956

  Fly  1352 SSAYGTRVKRTPGGGSIHY----NP-SYTPSSVAHA--------GGAHHPSAGSAQIIAAPAAST 1403
                      .||.|...|    .| .|.|.:|.|.        .|:.|.:.|..|  |..||||
Human   957 ----------VPGQGDSRYPLLGQPLQYNPPAVLHGHIPNQQGQPGSRHGNRGRRQ--AKKAAST 1009

  Fly  1404  1403
            Human  1010  1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	28/59 (47%)
		SUZ	527..578	CDD:289518	27/61 (44%)
R3HDM1	NP_001365036.1	R3H_encore_like	167..228	CDD:100071	30/62 (48%)
		SUZ	251..302	CDD:403836	27/57 (47%)
		Glutenin_hmw	<653..>855	CDD:367362	59/289 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10344
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3919
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm42015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8676
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.040