DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and R3HDM2

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	XP_011536344.1	Gene:	R3HDM2 / 22864	HGNCID:	29167	Length:	1073	Species:	Homo sapiens

Alignment Length:	972	Identity:	246/972 - (25%)
Similarity:	378/972 - (38%)	Gaps:	250/972 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |.:||::|||..|.||..|..:||.|||:||.:|||:|:::::|:.:|:...: :||..:||:||
Human   147 SRDSSQEYTDSTGIDLHEFLVNTLKKNPRDRMMLLKLEQEILEFINDNNNQFK-KFPQMTSYHRM 210

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFD- 542
            |:||.||:|||:|||| :|.:.||:....||||||.||...::|:     .::.|||||..|.|
Human   211 LLHRVAAYFGMDHNVD-QTGKAVIINKTSNTRIPEQRFSEHIKDEKNTEFQQRFILKRDDASMDR 274

  Fly   543 ---EVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSR-TGGN---------HDGYSGGG--- 591
               ::|     .||...|::||.|||||:|.|.|.|||:| ||.|         .:.:|...
Human   275 DDNQIR-----VPLQDGRRSKSIEEREEEYQRVRERIFARETGQNGYLNDIRLSKEAFSSSSHKR 334

  Fly   592 -----GDEECYGGWEQQQQQQKQSQ----PPRPKRPNGKMLQMQNSTESRDGMRS-GGAVPKSHN 646
                 |:.|........:|....|:    .|||          .:||:|...:|| ...|.|:.:
Human   335 RQIFRGNREGLSRTSSSRQSSTDSELKSLEPRP----------WSSTDSDGSVRSMRPPVTKASS 389

  Fly   647 FGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDS------------TGSTPWR-LSPSSS 698
            |.           |.:.|.||||..|.|.|..|.:.:..            |.|...| |.|.::
Human   390 FS-----------GISILTRGDSIGSSKGGSAGRISRPGMALGAPEVCNQVTSSQSVRGLLPCTA 443

  Fly   699 GYKTRTQSVRSDSVTPSPTGYGSDRQTPELNH---------------PSMMSHSR-------VAP 741
            ..:.:.|..:..::.|:|      :|.|.||:               |...|.|.       |:|
Human   444 QQQQQQQQQQLPALPPTP------QQQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSP 502

  Fly   742 PMSSGGGGVVGGGGSGAVTVSSVEMGTEATGADPSSTSNCSSGTSGIVWAVTDISNVPIGSLLID 806
            |........: ....|.:::|. :..|||  ||||:.          ::....||..|..:..|.
Human   503 PQQYNMADDL-SNPFGQMSLSR-QGSTEA--ADPSAA----------LFQTPLISQHPQQTSFIM 553

  Fly   807 PQTLQPIVNADGSIYHYDPSN---LPPNQALQ---------HSGNQYQSQNQGNSSSGGYNNYRK 859
            ..|.||:..::.|...:.|..   |||...:|         :...||.:.||         .||.
Human   554 ASTGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPNSNQ---------QYRP 609

  Fly   860 SSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELSCSSTESYAEEEAQSPGMECSEG 924
            .|.......|:.||..|..||...||...:||                     :|...||   .|
Human   610 LSHPVAYSPQRGQQLPQPSQQPGLQPMMPNQQ---------------------QAAYQGM---IG 650

  Fly   925 YESYEQQSLPVQQQLSGNGDSASTKGDDCDSLA---SATACLSITTSTSTKNYDRIEVQKYK--- 983
            .:..:.|.|...|:        |:.|.....|.   :......:...:.::|..:...|:..
Human   651 VQQPQNQGLLSSQR--------SSMGGQMQGLVVQYTPLPSYQVPVGSDSQNVVQPPFQQPMLVP 707

  Fly   984 -NQATSPNIPACCAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSS------QTPL 1041
             :|:....:||           ||:|......|   |:.....:.|||..:.|.|      |:|.
Human   708 VSQSVQGGLPA-----------AGVPVYYSMIP---PAQQNGTSPSVGFLQPPGSEQYQMPQSPS 758

  Fly  1042 P-MVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQ----------- 1094
            | ...|:......||||.......::..|:....|    :.|....|::.:.|.
Human   759 PCSPPQMPQQYSGVSPSGPGVVVMQLNVPNGPQPP----QNPSMVQWSHCKYYSMDQRGQKPGDL 819

  Fly  1095 -APDGSTVFHTTTTPNGAAPYCATTYQQGPD--GSIYAVPQGM----VYAAYPQPGVGTAGG--- 1149
             :||.|.   ...|...::|..:.|....|.  .|:.:|..|:    |...:|:|| |.|.|
Human   820 YSPDSSP---QANTQMSSSPVTSPTQSPAPSPVTSLSSVCTGLSPLPVLTQFPRPG-GPAQGDGR 880

  Fly  1150 ---ASQPLFQLTTSSHPP---AQTIFASPEAGAEIPGGTY----MIPVFDPAQQPREGLIPAQAI 1204
               ..||| |...|..||   .|:.:...:|...:.|...    |..||.        ::..|:.
Human   881 YSLLGQPL-QYNLSICPPLLHGQSTYTVHQADILMQGSQCCLHGMRVVFQ--------MLKGQSG 936

  Fly  1205 YQTGPGG-----PGATTVMPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQL 1261
            .:.|..|     ..|:|.:..|........: .|..|.|....:|..:::.....||::|.|
Human   937 LKHGNRGKRQALKSASTDLGTADVVLGRVLE-VTDLPEGITRTEADKLFTQLAMSGAKIQWL 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	28/59 (47%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	24/59 (41%)
R3HDM2	XP_011536344.1	R3H_encore_like	176..237	CDD:100071	29/62 (47%)
		SUZ	258..311	CDD:289518	25/57 (44%)
		Med15	471..>863	CDD:255446	93/467 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10344
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3919
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm42015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8676
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.040