DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and R3hdm1

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	NP_001344411.1	Gene:	R3hdm1 / 226412	MGIID:	2448514	Length:	1135	Species:	Mus musculus

Alignment Length:	1088	Identity:	273/1088 - (25%)
Similarity:	398/1088 - (36%)	Gaps:	366/1088 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |.:||::|||..|.||..|..:||..||:||.:|||:|::::||: .|:.....:|||.:||:||
Mouse   138 SRDSSQEYTDSTGIDLHEFLVNTLKNNPRDRMMLLKLEQEILDFI-GNNESPRKKFPPMTSYHRM 201

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFDE 543
            |:||.||:||::|||| ::.:.|||....|||||:.:|...::||     .::.|||||..|||:
Mouse   202 LLHRVAAYFGLDHNVD-QSGKSVIVNKTSNTRIPDQKFNEHIKDDRGEDFQKRYILKRDNSSFDK 265

  Fly   544 VRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTG-GNHDGY--SGGGGDEECYGGWEQQQ- 604
             ..|.....|..||::||.|||||:|.|||.||||:.. .:.:.|  .....||:..|..:::|
Mouse   266 -DDSQMRIRLKDDRRSKSIEEREEEYQRARDRIFSQDSLCSQENYIIDKRIQDEDTIGTQQRRQI 329

  Fly   605 -------------------QQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRS-GGAVPKSHNFGN 649
                               :.:.:...|||          .:||:|...:|: ..||.|:.:|.
Mouse   330 FRVNKDASGRSTNSHQSSTENELKYSEPRP----------WSSTDSDSSLRNLKPAVTKASSFS- 383

  Fly   650 YGGPPSSGGPGNNSLPRGDSTNSIKS-GRGGFVKQDSTGSTPWRLSPSSSGYKTRTQ-----SVR 708
                      |.:.|.||||:.|.|| ||......:|:||.     .||:|..:.||     |..
Mouse   384 ----------GISVLTRGDSSGSSKSIGRLSKTGSESSGSV-----GSSTGSLSHTQQPLPGSAL 433

  Fly   709 SDSVTPSPTGYGSDRQTPELNHPSMMSHSRVAPPMSSGGGGVVGGGGSGAVTVSSVEMGTEATGA 773
            |.|...:|..|           |:..:||.:     |..||:.|.|.|  .:.|.:.:..||||
Mouse   434 SQSSHGAPVIY-----------PAASNHSSL-----SFDGGLSGQGAS--PSTSFLLLPLEATG- 479

  Fly   774 DPSSTSNCSSGTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYDP------------- 825
                                    :|.||:||:|||.||.:|.|||...|:|
Mouse   480 ------------------------IPPGSILINPQTGQPFLNPDGSPVVYNPPMTQQPVRTQVPG 520

  Fly   826 ---SNLPPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQ 887
               ..|||....|.:.:...||..|                                 .||...|
Mouse   521 PPQPPLPPPPPQQPAASHMFSQPVG---------------------------------PLQSSSQ 552

  Fly   888 LHQQSSQQYATTELSCSSTESYAEEE----------AQSPGMECSEGYESYEQQSLPVQQ-QLSG 941
            ..|.|...|.:..|..|.|:.|:.:.          |:.|..:.|:.:.:..|.::.:|. |.||
Mouse   553 PVQCSPAPYPSPLLPVSPTQQYSVDNLGAQFSHMSLARQPSADGSDPHATMFQSTVVLQSPQQSG 617

  Fly   942 ------------------------NGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKY 982
                                    .|.|..|              .|.:.|....:...::.|.:
Mouse   618 YIVTTAPPHPPPPPPPPPPPPSLPPGQSVPT--------------ASFSASGHPVSQPVLQQQGF 668

  Fly   983 KNQATSPNIPAC-CAVGEKLELEAGLPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQ 1046
            ..| .||.:||| ||.|   ...:..||.:                            |:|.|:.
Mouse   669 LPQ-PSPQMPACYCAPG---HYHSSQPQYR----------------------------PIPSVHH 701

  Fly  1047 VNCDLQSVSPSTTPYSQCEV-KTPSQNHAPSAAVEEPKTTTWTYTQSYQAPDGSTVFHTTTTPNG 1110
             :..|....|....::..:| ....||:.....|:.|        ||.....|.        ||.
Mouse   702 -SSHLNQPLPQPAQHTGYQVMPNQQQNYQGIVGVQSP--------QSQSLMGGQ--------PNS 749

  Fly  1111 AAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAG 1175
            ..|:.                ||:|   .|.|.|        |.:|::.            |:..
Mouse   750 TGPHI----------------QGVV---IPYPSV--------PSYQVSL------------PQGS 775

  Fly  1176 AEIPGGTYMIPVFDPAQQPREGLIPAQAI---YQTGPGG--------------PGATTV-MPMAT 1222
            ..|...||..||..| .|..:|.:|...:   |...|.|              ||:..| .|..|
Mouse   776 QGIAHQTYQQPVVFP-NQSNQGSLPTTGMPVYYSVIPPGQQSNLSSAVGYLQHPGSEQVQFPRTT 839

  Fly  1223 AAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQ--LPMAPYPIQYSYPYYHPISYYVPQQ 1285
            :   |.:.........|.:.|.|      ||||..:.|  ||..|....:|.|.:....:|...|
Mouse   840 S---PCSSQQLQGHQCAAVPQQP------PGGGMVMMQLNLPNNPQSRTHSPPQWKQNKHYCDHQ 895

  Fly  1286 AVAAA-------PMVASQPQVGQ---APMQQQAPHTGAGTTT----GPP-TVVS------VSGQ- 1328
            .....       .:|...||:..   :|:|..||...:...|    ||| :::|      |.||
Mouse   896 RGQKCMDFSNMDNIVQPSPQLSSPILSPVQSPAPAQLSTLKTIRPSGPPLSIMSQFARPFVPGQG 960

  Fly  1329 -------------------QHHQPHQQHHQQQQHSSNGSVVTSSAYGT 1357
                               ..|.||||.....:|.:.|......|..|
Mouse   961 DARYPLLGQPLQYNPPTLLHGHIPHQQGQSGSRHGNRGRRQAKKAAST 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	28/59 (47%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	27/55 (49%)
R3hdm1	NP_001344411.1	R3H_encore_like	167..228	CDD:100071	30/62 (48%)
		SUZ	251..302	CDD:315432	27/51 (53%)
		PAT1	682..>917	CDD:330585	65/331 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10397
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm44068
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8676
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.990