DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and ARPP21

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	NP_001372524.1	Gene:	ARPP21 / 10777	HGNCID:	16968	Length:	848	Species:	Homo sapiens

Alignment Length:	1004	Identity:	255/1004 - (25%)
Similarity:	370/1004 - (36%)	Gaps:	288/1004 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PHNNSSTGVIFNSGMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHR--AN 360
            |.|    |::.:..::.:  |:.:...|.|..:|....|.:           |.|.||..|  |.
Human    24 PEN----GIVKSESLDEE--EKLELQRRLEAQNQERRKSKS-----------GAGKGKLTRSLAV 71

  Fly   361 TNAKGNKPRLKNLGGSSSGSIDLGGGGG----NGNCNNMSNNGQSNNSSNNTSGFISRVFHQSEN 421
            ......:|..::|....|..:.|.....    :.:..:.|...:..:.:.:.:....::...|::
Human    72 CEESSARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSEREKEKDKNKDKTSEKPKIRMLSKD 136

  Fly   422 SSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRMLIH 486
            .|::|||..|.||..|..:||..|.:||.||||:|:::|||:.:|:...: :||..|||.|||:|
Human   137 CSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEIIDFIADNNNHYK-KFPQMSSYQRMLVH 200

  Fly   487 RTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFD-EVR 545
            |.||:||::|||| :|.:.||:....:|||||.||...::|:     .::.|||||..|.| |..
Human   201 RVAAYFGLDHNVD-QTGKSVIINKTSSTRIPEQRFCEHLKDEKGEESQKRFILKRDNSSIDKEDN 264

  Fly   546 QSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTG----------------------------- 581
            |...:.|...||::||.|||||:|.|.|.|||:...
Human   265 QQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDSVCSQESLFVENSRLLEDSNICNETYKKRQ 329

  Fly   582 ---GNHDGYSGGGGDEECYGGWEQQQQQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRS-GGAVP 642
               ||.||.....|..:     ...:.:.|.|...|          ..:||:|....|: ..|:.
Human   330 LFRGNRDGSGRTSGSRQ-----SSSENELKWSDHQR----------AWSSTDSDSSNRNLKPAMT 379

  Fly   643 KSHNFGNYGGPPSSGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGYKTRTQSV 707
            |:.:||           |...|.|||||:|.:|..    |....||:....|..|||..:||
Human   380 KTASFG-----------GITVLTRGDSTSSTRSTG----KLSKAGSSESSSSAGSSGSLSRT--- 426

  Fly   708 RSDSVTPSPTGYGSDRQTPELNHPSMMSHSRVAPPMSSGGGGVVGGGGSGAVTVSSVEMGTEATG 772
                                  ||.:.|     .|:.||    |..|..|.|......:|.:..
Human   427 ----------------------HPPLQS-----TPLVSG----VAAGSPGCVPYPENGIGGQVA- 459

  Fly   773 ADPSSTSNCSSGTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYDPSNLPPNQALQHS 837
              |||||.       |:..:...:.:|.||:|::|.|.||.||.||:...|:|   |.:|....|
Human   460 --PSSTSY-------ILLPLEAATGIPPGSILLNPHTGQPFVNPDGTPAIYNP---PTSQQPLRS 512

  Fly   838 GNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQPQQLHQQSSQQYATTELS 902
            ....|||.|               |.|||.|.|.||..|..|.|:..|  |..||.|
Human   513 AMVGQSQQQ---------------PPQQQPSPQPQQQVQPPQPQMAGP--LVTQSVQ-------- 552

  Fly   903 CSSTESYAEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKGDDCDSLASATACLSITT 967
                           |::.|.....|...|.|.|..|..:........||.     ||....:|.
Human   553 ---------------GLQASSQSVQYPAVSFPPQHLLPVSPTQHFPMRDDV-----ATQFGQMTL 597

  Fly   968 STSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAG--LPQEQEQEPMAGPSSSGSATSSVG 1030
            |..:.                         ||..|..:|  .|.....:|...||...::|..
Human   598 SRQSS-------------------------GETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQ-- 635

  Fly  1031 ITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQNHAPSAAVEEPKTTTWTYTQSYQA 1095
              :||:.               ..|.|..|.||..::.|.   :|...|::|.......   |..
Human   636 --QLPTG---------------GFSGSGPPISQQVLQPPP---SPQGFVQQPPPAQMPV---YYY 677

  Fly  1096 PDGSTVFHTTTT----PNGAAPYCATTYQQGPDGSIYAVPQGMVYAAYPQPGV-------GTAGG 1149
            |.|.  :.|:||    |.....|.|...||        :||....|.| ||.:       |..|.
Human   678 PSGQ--YPTSTTQQYRPMAPVQYNAQRSQQ--------MPQAAQQAGY-QPVLSGQQGFQGLIGV 731

  Fly  1150 ASQPLFQ--LTTSSHPPAQTIFAS-----------PEAGAEIPGGTYMIPVFDPAQQPREGLIPA 1201
            ...|..|  :......|.|::..|           .:....:|..:|..|:..| .|..:|.:||
Human   732 QQPPQSQNVINNQQGTPVQSVMVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLP-NQAGQGSLPA 795

  Fly  1202 QAIYQTGPGGPGATTVMPMATAAAYPTAQ 1230
                          |.||:......||.|
Human   796 --------------TGMPVYCNVTPPTPQ 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	31/59 (53%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	25/56 (45%)
ARPP21	NP_001372524.1	R3H_encore_like	163..224	CDD:100071	32/62 (52%)
		SUZ	245..300	CDD:403836	25/54 (46%)
		PHA03247	<428..695	CDD:223021	93/385 (24%)
		gliding_GltJ	<597..>809	CDD:411345	57/287 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154957
Domainoid	1	1.000	62	1.000	Domainoid score	I10344
eggNOG	1	0.900	-	-		E1_KOG2953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3919
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm42015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8676
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.970