DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment enc and r3hdm1

DIOPT Version :9

Sequence 1:	NP_001261376.1	Gene:	enc / 44543	FlyBaseID:	FBgn0004875	Length:	1942	Species:	Drosophila melanogaster
Sequence 2:	XP_004917702.2	Gene:	r3hdm1 / 100379746	XenbaseID:	XB-GENE-984253	Length:	1125	Species:	Xenopus tropicalis

Alignment Length:	1131	Identity:	286/1131 - (25%)
Similarity:	424/1131 - (37%)	Gaps:	311/1131 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 SENSSEQYTDYGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEYRFPPASSYNRM 483
            |.:||::|||..|.||..|..:||..||:||.:|||:|:|::||:..| .....:|||.:||:||
Frog   138 SRDSSQEYTDSTGIDLHEFLVNTLKSNPRDRMMLLKLEQDILDFIGTN-ESQRKKFPPMTSYHRM 201

  Fly   484 LIHRTAAFFGMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFD- 542
            |:||.||:||::|||| ::.:.|||....|||||:.:|:..::|:     .::.|||||..|.|
Frog   202 LLHRVAAYFGLDHNVD-QSGKSVIVNKTSNTRIPDQKFEEHIKDEKNVDFQKRYILKRDNSSLDK 265

  Fly   543 ---EVRQSPYLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNHDGYSGGGGDEECYGGWEQQQ 604
               ::|..     |..||::||.|||||:|.|||.|||::.            .:|.|  ...::
Frog   266 DDNQMRMR-----LKEDRRSKSIEEREEEYQRARERIFAQE------------SQENY--LSDKR 311

  Fly   605 QQQKQSQPPRPKRPNGKMLQMQNSTESRDGMRSGGAV-PKSHNFGNYGGP-PSSGGPGNNSL--- 664
            .|:::|...:.:|      |:....:...| |||.:: ..:.|.|.|..| |.|....::|:
Frog   312 IQEEESNSTQQRR------QIFRINKDASG-RSGNSLFSSTENDGKYNEPRPWSSTDSDSSIRNL 369

  Fly   665 -PRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGYKTRTQSVRSDSVTPSPTGYGSDRQTPE- 727
             |.....:|. ||.....:.||:||:      .|:|..::..|..|.||..|.......:|.|:
Frog   370 KPAVTKASSF-SGISVLTRGDSSGSS------KSTGRLSKAGSESSSSVGSSTGSLSHTQQQPQQ 427

  Fly   728 ----LNHPSMMSHSRVA--PPMSSGGGGVVGGGGSGAVTVSSVE---MGTEATGADPSSTSNCSS 783
                :|..|..:|...|  ||:|:.......|..:|.||..|..   :..||||
Frog   428 QSLPVNALSQPAHGTAAVYPPVSTSNSLSFDGAINGQVTPPSASFFLLPLEATG----------- 481

  Fly   784 GTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYD------------------PSNLPP 830
                          :|.||:||:|||.||.:|.||:...|:                  |..:||
Frog   482 --------------IPPGSILINPQTGQPFINPDGTPVVYNPPVTQQPVRTQVPAPAPPPPPVPP 532

  Fly   831 NQALQHSGNQYQSQNQGNSSSGGYN--NYRKS----SPHQQQQSQQQQQSQQHHQQQLQQP--QQ 887
            .|...|..:|.......::....|:  :|...    ||.||........||..|....:||  ..
Frog   533 QQPTNHILSQPLRSLPSSAQPVQYSAVSYPPPLLPVSPTQQYTVPDNLGSQFSHMSLARQPSADN 597

  Fly   888 LHQQSSQQYATTELSCSSTESY--AEEEAQSPGMECSEGYESYEQQSLPVQQQLSGNGDSASTKG 950
            ....|:...:|..|..|:...|  |.....:|.:..|....:|...:.||.|.:      ...:|
Frog   598 SDAHSTMFQSTVVLQPSAQPGYIMAPPPPPAPPLGQSVPPPTYSASNPPVNQPV------MQQQG 656

  Fly   951 DDCDSLASATACLSITTS--TSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELE------AGL 1007
            ....|:.....|......  .|::.|..:...:|.:||:.....|....|....:.      .|:
Frog   657 FMQPSIQQIPTCYCAPNQYPHSSQQYRPVASVQYSSQASQSLPQAAHTTGFPTVMSNQQPNFQGI 721

  Fly  1008 PQEQEQEPMAGPSSSGSATSSVGI----TELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKT 1068
            .|:.:.:.:.|...|.......|:    :.:||.|.|:...:|        |.|..||.| .|..
Frog   722 VQQPQNQALVGGQPSNLTNPIQGVMVQYSSVPSYQVPVRQSSQ--------SVSQQPYHQ-PVLI 777

  Fly  1069 PSQ-NHAPSAAVEEP---------KTTTWTYTQSYQAPDGS--TVFHTTTTPNGAAPYCATTYQQ 1121
            ||| |..|..|...|         :....:.:..:..|.||  ..|:.||:|      |.|....
Frog   778 PSQSNPGPLPAAGMPVYYSVISPGQQNNMSSSVGFIQPSGSEPIQFNRTTSP------CNTQPMP 836

  Fly  1122 GPDGSIYAVPQGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASP-------------- 1172
            ||...  |||.       |.||.|..      :.||...::||.||  .||
Frog   837 GPQCG--AVPA-------PPPGGGMV------MMQLNVPNNPPPQT--HSPPQWKPNKYYCDHQR 884

  Fly  1173 -EAGAEIPG-------GTYM-IPVFDPAQQP-----------REGLIPAQAIYQTGPGGPGATTV 1217
             :...|...       .|:: .||..|.|.|           |.||.|
Frog   885 AQKSIEYSSLDHTTQHNTHLGSPVTSPNQSPLPVHLTNMKNIRPGLTP----------------- 932

  Fly  1218 MPMATAAAYPTAQFATAAPNGAPIYQAPLIYSSEPGGGAQLQQLPMAPYPIQYSYPYYHPISYYV 1282
            :|:.|..:.|     ..|..|...|                   |:...|:.|:.|  |.|..::
Frog   933 LPLVTQFSRP-----FTAGQGDTRY-------------------PLLGQPLHYNAP--HVIQGHI 971

  Fly  1283 PQQAVAAAPMVASQPQVGQAPMQQQAPHTGAGTTTGPPTVVSVSGQQHHQPHQQHHQQQQHSSNG 1347
            .||         .||........::||...|.|...|...| |||.                  |
Frog   972 NQQ---------GQPGHRHGNRGKKAPKKAASTDLCPGDPV-VSGM------------------G 1008

  Fly  1348 SVVTSSAYGTRVKR----------TPGGGSIH-----------YNPSYTPSSVAHAGGAHHPSAG 1391
            .|:..:.....:.|          :..|.||.           ::|.|..|...|....|..
Frog  1009 KVLEITELPEGISRKDAEMLLGDLSKAGASIRWLREPRSQPTPHHPHYCGSGENHTSSEHSN--- 1070

  Fly  1392 SAQIIAAP-AASTTTYHA-LPTLTLA 1415
                 |:| .|||.|..| .||::.|
Frog  1071 -----ASPDLASTYTIVATFPTVSAA 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	29/59 (49%)
enc	NP_001261376.1	SUZ	527..578	CDD:289518	25/59 (42%)
r3hdm1	XP_004917702.2	PTZ00449	<34..>127	CDD:185628
		R3H_encore_like	167..228	CDD:100071	31/62 (50%)
		SUZ	251..302	CDD:403836	25/67 (37%)
		PRK10263	<635..>848	CDD:236669	52/242 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001600
OrthoInspector	1	1.000	-	-		otm49242
Panther	1	1.100	-	-	O	PTHR15672
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.100