Protein Alignment enc and r3hdm2

DIOPT Version :10

• Sequence 1: NP_001261376.1
• Gene: enc / 44543
• FlyBaseID: FBgn0004875
• Length: 1942
• Species: Drosophila melanogaster
• Sequence 2: XP_073810886.1
• Gene: r3hdm2 / 100330669
• ZFINID: ZDB-GENE-180313-1
• Length: 1052
• Species: Danio rerio
• Alignment Length: 1316
• Identity: 289/1316 - (21%)
• Similarity: 418/1316 - (31%)
• Gaps: 489/1316 - (37%)

  Fly   311 GMNYKAAERHDRHERHEMSSQNSNLSNNHDEEPYHYEPRGGGGGKKHRANTNAKGNKPRLKNLGG 375
            |.|..:|...|.:.  :.:..:.|||.:......::      |..:.||.:|||....|...:..
Zfish    27 GKNSPSANSKDCNT--DNTEPDDNLSQDAQRRCQNH------GHTRKRAKSNAKLKLVRSLAVCE 83

  Fly   376 SSSGSIDLGGGGGNG-------NC-----NNMSNNGQSNNSSNNTSGFISRVFHQSENSSEQYTD 428
            .|||.....|...:.       :|     ...|:..:|.|..........|.. .|.:||::|||
Zfish    84 ESSGPFSTDGPPESQDIIQLHISCPSDKEEEKSSKDESENEEREKKDKTPRKM-LSRDSSQEYTD 147

  Fly   429 YGGTDLLVFFRDTLNKNPKDRNILLKIEKDLIDFVQENSRGCEY-RFPPASSYNRMLIHRTAAFF 492
            ..|.|:..|..:||..||:||.:|||:|:|:::|:.:.:.  :| :||..:||:|||:||.||:|
Zfish   148 STGIDVHEFLVNTLKNNPRDRMMLLKLEQDILEFISDENN--QYKKFPQMTSYHRMLLHRVAAYF 210

  Fly   493 GMEHNVDTETQQCVIVAVAKNTRIPEIRFQSLVRDD-----ARKSILKRDTHSFD----EVRQSP 548
            ||:|||| :|.:.||:....||||||.||...::|:     .:|.|||||..|.|    ::|
Zfish   211 GMDHNVD-QTGKAVIINKTSNTRIPEQRFSEHIKDERNMDFQKKFILKRDDASMDKDDNQIR--- 271

  Fly   549 YLCPLSLDRKAKSFEEREEDYDRARSRIFSRTGGNH----------DGYSGGG--------GDEE 595
              .||...|::||.|||||:|.|.|.|||:|....:          ||||...        |:.|
Zfish   272 --VPLQDGRRSKSIEEREEEYQRVRDRIFARESSQNGYINDNRLSTDGYSSSSQKRRQIFRGNRE 334

  Fly   596 CYGGWEQQQQQQKQSQ----PPRPKRPNGKMLQMQNSTESRDGMRS-GGAVPKSHNFGNYGGPPS 655
            ........:|....|.    .|||          .:||:|....|: ...|.|:.:|.
Zfish   335 SSSRASSSRQSSTDSDMKSLEPRP----------WSSTDSDSSNRTLRPPVTKASSFS------- 382

  Fly   656 SGGPGNNSLPRGDSTNSIKSGRGGFVKQDSTGSTPWRLSPSSSGYKTRTQSVRSDSVTPSPTGYG 720
                |.:.|.||||..| |..:|                 |:.|.:|...::..|...||..|.|
Zfish   383 ----GISILTRGDSLGS-KGSQG-----------------SARGSRTGLPTITPDLCPPSQQGRG 425

  Fly   721 --------------SDRQ--------TPELNHPSMMSHSRVAPPMSSGGGGVVGGGGSGAVTVSS 763
                          :..|        ||...| ::.:|:.:.|.                 .|:|
Zfish   426 LLPCPQNCPSGAPQAPNQPPAPPLLPTPTHTH-AISAHNHMMPQ-----------------PVAS 472

  Fly   764 VEMGTEATGADPSSTSNCSSGTSGIVWAVTDISNVPIGSLLIDPQTLQPIVNADGSIYHYDPSNL 828
            ::...:|.     |.||.|.                       ||.|.|:          .||
Zfish   473 LQASAQAV-----SYSNPSC-----------------------PQVLLPV----------SPS-- 497

  Fly   829 PPNQALQHSGNQYQSQNQGNSSSGGYNNYRKSSPHQQQQSQQQQQSQQHHQQQLQQP------QQ 887
                         |..|.|:..:.|:.         |....:|..|:......|.||      ||
Zfish   498 -------------QQYNMGDELTQGFG---------QMSLSRQGSSEAPEPPSLYQPPPTLLTQQ 540

  Fly   888 LHQQSSQQYATT--------ELSCSSTESYAEEEAQSPG---MECSEGYESYEQQSLPVQQQLSG 941
            |.|....|.:..        :.:...|.::.......|.   ::.:...:.|.|...|.||
Zfish   541 LTQHPPPQPSYIMPPPPSGYQPAAPHTHTHPPPPPPPPAQPILQTAPPAQGYMQAPPPPQQ---- 601

  Fly   942 NGDSASTKGDDCDSLASATACLSITTSTSTKNYDRIEVQKYKNQATSPNIPACCAVGEKLELEAG 1006
                                               |:||.|......|
Zfish   602 -----------------------------------IQVQYYSTAGQFP----------------- 614

  Fly  1007 LPQEQEQEPMAGPSSSGSATSSVGITELPSSQTPLPMVNQVNCDLQSVSPSTTPYSQCEVKTPSQ 1071
                                        ||.|....:.:||:...|...|...|
Zfish   615 ----------------------------PSGQQFRSISHQVSFPSQRSQPLPPP----------- 640

  Fly  1072 NHAPSAAVEEPKTT----TWTYTQSYQAPDGSTVFHTTTTP-NGAAPYCATTYQQGPDGSIYAVP 1131
              ||.:|..:|..|    .:......|.|..|::.:|..|. ||........|...|.   |.||
Zfish   641 --APPSAPLQPMMTNQQPAYQGMMGVQQPQSSSMMNTQRTAINGQMTGMMVQYPPMPS---YQVP 700

  Fly  1132 QGMVYAAYPQPGVGTAGGASQPLFQLTTSSHPPAQTIFASPEAGAEIPGGTYMIPVFDPAQQPRE 1196
                        |...|   ||:.|                        ..|..||..||.|..:
Zfish   701 ------------VANEG---QPVVQ------------------------QQYQQPVMVPASQSVQ 726

  Fly  1197 GLIPAQAIYQTGPGGPGATTVMPMATAAAYPTAQFATAAPNG---------------------AP 1240
            |.:|..|             .||:......||.|.:|:|..|                     .|
Zfish   727 GAMPTAA-------------PMPVYYGVLTPTQQNSTSASVGYLQPPSSEQYQMTQSAPPCSPQP 778

  Fly  1241 IYQAPLIYSS--EPGGGAQLQQL--PMAPYPIQYSYP--YYHPISYY-VPQQAVAAAPMVASQ-- 1296
            |.|.   ||.  .||.|..:.||  |..|.|.| :.|  .::|..|| :.|:.....|.|:|.
Zfish   779 IQQQ---YSGVPPPGPGVMVMQLSVPNGPQPTQ-NPPLVQWNPCKYYSMEQRGSKPEPQVSSPLA 839

  Fly  1297 ------------------PQVGQAPMQQQAPHTGAGTTTG--------------PPTVVSVSGQQ 1329
                              |.:|..|:..|.|..|.....|              ||.::....|.
Zfish   840 SPTQSPAPSPSGSVNSVCPGLGPLPLISQFPRPGGPAQDGRYSLLGQPLQYSLCPPPIMHNHNQS 904

  Fly  1330 HHQPHQ------QHHQQQQHSSNGSVVTSSAYGTRVKRTPGGGSIHYNPSYTPSSVAHAGGAHHP 1388
            .:..||      |:....:|.:.|...|..:..|.:..|....|.....:..|.      |...|
Zfish   905 SYSSHQCVCVFAQNQGVMKHGARGKRQTLKSASTDLGTTDMVVSRVLEVTDLPE------GISRP 963

  Fly  1389 SA-----------GSAQIIAAPAASTTTYHALPTLTLAHGGPATGTDLSGAGGAHVYALPAQHAL 1442
            .|           ...|.:..|....              ||..|.. .|:..||:|.:.|
Zfish   964 EAEKLFNQLSLCGAKIQWLKDPQCPR--------------GPGGGRG-DGSDPAHLYTVVA---- 1009

  Fly  1443 IPTNIFPYAAAAAAAA 1458
                :||...||..|:
Zfish  1010 ----VFPNTMAAQNAS 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
enc	NP_001261376.1	R3H_encore_like	448..508	CDD:100071	29/60 (48%)
		SUZ	530..578	CDD:463689	24/51 (47%)
		PRK10263	<1103..>1304	CDD:236669	55/249 (22%)
r3hdm2	XP_073810886.1	None