DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and ONECUT2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_004843.2	Gene:	ONECUT2 / 9480	HGNCID:	8139	Length:	504	Species:	Homo sapiens

Alignment Length:	632	Identity:	141/632 - (22%)
Similarity:	208/632 - (32%)	Gaps:	220/632 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1219 AYPSSLHGRKSEGGGTPAPPAPPSGP---GTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPAL 1280
            |.||..|..:...|....||.||:..   ||.|.|        ..|:|.||..:.:: |||
Human    63 ASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAA--------AAAASRSAMVTSMA-SIL---- 114

  Fly  1281 SSQGEEFAATAS-PLQRMASITNSLITQPP-----VTPHHSTPQRPTKAVLPPITQQQFDMFNNL 1339
              .|.::....| ||....|:  |..:.||     .|....||.:|    ||||:
Human   115 --DGGDYRPELSIPLHHAMSM--SCDSSPPGMGMSNTYTTLTPLQP----LPPIS---------- 161

  Fly  1340 NTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMK----- 1399
                                             :|||....|.|.|...........|:.
Human   162 ---------------------------------TVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSG 193

  Fly  1400 --MFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEP 1462
              ..:.||..   |.|.....:|.|.|        |.|.|.|:   ..|:.|:...:..|
Human   194 SFTLMRDERG---LPAMNNLYSPYKEM--------PGMSQSLS---PLAATPLGNGLGGL----- 239

  Fly  1463 AQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPH--- 1524
                                                                 |.|||..|:
Human   240 -----------------------------------------------------HNAQQSLPNYGP 251

  Fly  1525 QQHHQAAAAAAALHHQSMLLTSPGLPPQH---AISLPPSAGGAQPGG---PGGNQGSSNPSNSEK 1583
            ..|.:..:.....||.:||...    .||   .:..||:|..:...|   ||..|...
Human   252 PGHDKMLSPNFDAHHTAMLTRG----EQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHG------- 305

  Fly  1584 KPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLS 1648
             |:|.|........|     |.:....:...::::|.::..:|...|...:|.|.||.:.||..|
Human   306 -PVLAPSRERPPSSS-----SGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRS 364

  Fly  1649 QGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQDN 1713
            ||::|:||..||||..|. .|||.|.||..||.:. ..:|:..|    |.|:.:|:...||:..|
Human   365 QGTLSDLLRNPKPWSKLK-SGRETFRRMWKWLQEP-EFQRMSAL----RLAACKRKEQEPNKDRN 423

  Fly  1714 SSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFL 1778
            :|                             .||.|::|::.|:..|...|..:..|:......:
Human   424 NS-----------------------------QKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITI 459

  Fly  1779 ANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDN-PIPSRESTSAT 1824
            :.:|||...|::|:|.|.|.|..::      .||: ......|||:|
Human   460 SQQLGLELTTVSNFFMNARRRSLEK------WQDDLSTGGSSSTSST 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	9/82 (11%)
		CUT	1616..1690	CDD:280527	29/73 (40%)
		Homeobox	1749..1801	CDD:278475	15/51 (29%)
ONECUT2	NP_004843.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..95		11/31 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..189		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..332		14/70 (20%)
		CUT	331..403	CDD:396794	28/73 (38%)
		HOX	426..481	CDD:197696	16/54 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..504		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910