DRSC/TRiP Functional Genomics Resources

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Protein Alignment ct and LHX2

DIOPT Version :9

Sequence 1:NP_524764.1 Gene:ct / 44540 FlyBaseID:FBgn0004198 Length:2175 Species:Drosophila melanogaster
Sequence 2:NP_004780.3 Gene:LHX2 / 9355 HGNCID:6594 Length:406 Species:Homo sapiens


Alignment Length:289 Identity:62/289 - (21%)
Similarity:94/289 - (32%) Gaps:85/289 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1594 NAMRSLHQHMSPTVYEMAALTQDLDTH----DITTKIKEALLANNIGQK-------IFGEAVLGL 1647
            :..|....|:..:..||....:||..|    ..||..|.....::.|.|       :..||:|  
Human   111 SVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALL-- 173

  Fly  1648 SQGSVSELLSKPKPWHM-------------------LSIKGREPFIRMQLWLSDANNVERLQLLK 1693
             ||..        |.|.                   |...|..|     |.|...|.|..:|   
Human   174 -QGEY--------PAHFNHADVAAAAAAAAAAKSAGLGAAGANP-----LGLPYYNGVGTVQ--- 221

  Fly  1694 NERREASKRRRSTGPNQQ----DNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSE 1754
               :...::|:|.||...    :.:...:.||........|.|.|        ..:|:.|..|..
Human   222 ---KGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSS--------QKTKRMRTSFKH 275

  Fly  1755 EQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQV--------------- 1804
            .|...::..||::..|:...::.||.:.||..|.:..||.|.|.:.::.:               
Human   276 HQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAA 340

  Fly  1805 -----PHGPAGQ-DNPIPSRESTSATPFD 1827
                 |.|||.: .|...|..||..|..|
Human   341 LQTGTPSGPASELSNASLSPSSTPTTLTD 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctNP_524764.1 CUT 886..955 CDD:280527
CUT 1335..1411 CDD:280527
CUT 1616..1690 CDD:280527 22/103 (21%)
Homeobox 1749..1801 CDD:278475 15/51 (29%)
LHX2NP_004780.3 LIM1_Lhx2 43..106 CDD:188853
LIM2_Lhx2_Lhx9 111..169 CDD:188763 12/57 (21%)
COG5576 <247..378 CDD:227863 31/131 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..270 5/27 (19%)
Homeobox 270..323 CDD:395001 15/52 (29%)
Nuclear localization signal. /evidence=ECO:0000255 307..323 5/15 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..374 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..406
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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