DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and PDLIM7

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_005442.2	Gene:	PDLIM7 / 9260	HGNCID:	22958	Length:	457	Species:	Homo sapiens

Alignment Length:	397	Identity:	79/397 - (19%)
Similarity:	113/397 - (28%)	Gaps:	156/397 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   924 LLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRG--AGGAGGD--- 983
            :|..|.||....:.|:|.           |..:.:..|.|         .|:.  ||.|.||
Human     7 VLEGPAPWGFRLQGGKDF-----------NVPLSISRLTP---------GGKAAQAGVAVGDWVL 51

  Fly   984 --DSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQ 1046
              |..:...:.||  ||.:.::...       ||.|.|...:   :..:|.||..::|
Human    52 SIDGENAGSLTHI--EAQNKIRACG-------ERLSLGLSRA---QPVQSKPQKASAP------- 97

  Fly  1047 LKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPS 1111
                                                            |..|     |.:.|:||
Human    98 ------------------------------------------------AADP-----PRYTFAPS 109

  Fly  1112 LFGGAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVL 1176
            :.......|..|    |..||.                ..||.....:...|:     |.:|:::
Human   110 VSLNKTARPFGA----PPPADS----------------APQQNGQPLRPLVPD-----ASKQRLM 149

  Fly  1177 NGAQDLSLAAAAAKDIKLNGQRSS---LEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPP 1238
            ...:|......       .||..|   |.|..|:.....        |...|.:||........|
Human   150 ENTEDWRPRPG-------TGQSRSFRILAHLTGTEFMQD--------PDEEHLKKSSQVPRTEAP 199

  Fly  1239 AP----PSGPGTGAGAP-PTAAPP--TGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQR 1296
            ||    |..|..|..|| ||:.||  ...|.:...||...|.     .|:...:  .||.:|||.
Human   200 APASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTST-----VLTRHSQ--PATPTPLQS 257

  Fly  1297 MASITNS 1303
            ..||..:
Human   258 RTSIVQA 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	7/30 (23%)
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
PDLIM7	NP_005442.2	PDZ_signaling	5..79	CDD:238492	22/100 (22%)
		Atrophin-1	<81..254	CDD:331285	50/282 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..142		17/142 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226		16/57 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258		7/25 (28%)
		LIM1_Enigma	282..333	CDD:188836
		LIM2_Enigma	341..392	CDD:188840
		LIM3_Enigma	400..454	CDD:188842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910