DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and PHOX2B

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_003915.2	Gene:	PHOX2B / 8929	HGNCID:	9143	Length:	314	Species:	Homo sapiens

Alignment Length:	240	Identity:	66/240 - (27%)
Similarity:	89/240 - (37%)	Gaps:	76/240 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1711 QDNSSDTSSNDTNDFYTSSPGPGSVG------------------SGVGGAPPSKKQ---RVLFSE 1754
            |.|...|:...|:...:.:||..|:|                  :..||....:||   |..|:.
Human    43 QYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTS 107

  Fly  1755 EQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQ----------VPHGPA 1809
            .|.:.|...||...||::.|.|.||.::.|....:..||.|.|.:.::|          ..:|.:
Human   108 AQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSS 172

  Fly  1810 GQDNPIPSR--ESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYP---PYFAA--AAILG 1867
            |:.:. .||  ||..|...||                   ..:|.|.|.|   |...|  ....|
Human   173 GKKSD-SSRDDESKEAKSTDP-------------------DSTGGPGPNPNPTPSCGANGGGGGG 217

  Fly  1868 RSLAGIPG------------------AAAAAGAAAAAAAVGASGG 1894
            .|.||.||                  |||||.|||||||..|:||
Human   218 PSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGG 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475	17/51 (33%)
PHOX2B	NP_003915.2	Homeobox	102..155	CDD:395001	17/52 (33%)
PHOX2B	NP_003915.2	polyalanine repeat	241..260		12/18 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910