Protein Alignment ct and ZFHX2

DIOPT Version :9

• Sequence 1: NP_524764.1
• Gene: ct / 44540
• FlyBaseID: FBgn0004198
• Length: 2175
• Species: Drosophila melanogaster
• Sequence 2: XP_016877205.1
• Gene: ZFHX2 / 85446
• HGNCID: 20152
• Length: 2576
• Species: Homo sapiens
• Alignment Length: 2041
• Identity: 397/2041 - (19%)
• Similarity: 618/2041 - (30%)
• Gaps: 711/2041 - (34%)

  Fly   523 AAERPMDASSNADLPESTKAPVPAEDD--EEDEDQAMLVDSEE--AEDKPEDSHHDDDEDEDEDR 583
            :::.|:|.||..::    :|.|...:|  .|.|.||:::..||  |...|.......|....:.:
Human   301 SSDIPLDNSSTVNM----EANVAQTEDGPPEAEVQALILLDEEVMALSPPSPPTATWDPSPTQAK 361

  Fly   584 EA-VNATTTDSNELKIKKEQHSPL--DLNVLSPNSAIAAA-AAAAAAAACANDPNKFQALLIERT 644
            |: |.|.....:.....:|:...|  .||..||.|..... .|...:....:||.:...|..:.|
Human   362 ESPVAAGEAGPDWFPEGQEEDGGLCPPLNQSSPTSKEGGTLPAPVGSPEDPSDPPQPYRLADDYT 426

  Fly   645 KALAAEALKNGASDALSEDAH----HQQQQ-----------HHQQQHQ---HQQQHHQQQHLHQQ 691
            .|.|       |...||..:|    |.:..           |::.|..   |.::.|.:.:.|..
Human   427 PAPA-------AFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCS 484

  Fly   692 H------HHHLQQQPNSGSNSNPASND-HHHGHHLHGHGLLHPSSAHHLHH----QTTESNSNS- 744
            :      |..|.:..:......|...| .::.....|:..:|..|..||.:    |.......|
Human   485 YCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQGSP 549

  Fly   745 ---STPTAAGNNNGSNNS-------SSNTNANSTAQLAASLASTLNGTKSLMQEDSNGLAAVAMA 799
               |.|.:||:......|       |..||.:...::..:....:.....|.|....||....|.
Human   550 PEASLPPSAGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLMG 614

  Fly   800 ------------------------AHAQHAAAL-GPGFLPGLPAFQFAAAQVAAGG---DGRGHY 836
                                    |..|....| |||..|..|    ..||:...|   .|....
Human   615 PGPPPPPGATPTSPPELFQYFGPQALGQPQTPLAGPGLRPDKP----LEAQLLLNGFHHVGAPAR 675

  Fly   837 RFADS-------ELQLPPGASMAGRLGESL---IPKGDPMEAKLQEMLRYNMDKYANQALDTLHI 891
            :|..|       :..||| :.:.|...:||   .|..|.:..|:...|       ..||..|..:
Human   676 KFPTSAPGSLSPDAHLPP-SQLLGSSSDSLPTSPPPDDSLSLKVFRCL-------VCQAFSTDSL 732

  Fly   892 SRRVRELLSVH-NIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYR-KMHAWACDDNA 954
                 |||..| :||:.|                     |..:..|...|::| |:   .|....
Human   733 -----ELLLYHCSIGRSL---------------------PEAEWKEVAGDTHRCKL---CCYGTQ 768

  Fly   955 VMLLKSLIPKKDS------------------GLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSL 1001
            :.....|..|.|.                  |.|..|..|.|...|..|....|......|::|.
Human   769 LKANFQLHLKTDKHAQKYQLAAHLREGGGAMGTPSPASLGDGAPYGSVSPLHLRCNICDFESNSK 833

  Fly  1002 MKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQ----SCTSPFFKVENQLKQHQHLNPEQAAAQQ 1062
            .|....|:....|..|...:.....|.:::..:    .|....::..::|...|||
Human   834 EKMQLHARGAAHEENSQIYKFLLDMEGAEAGAELGLYHCLLCAWETPSRLAVLQHL--------- 889

  Fly  1063 REREREQREREQQQRLR-----HDDQDKMARLYQELIA------RTPRETAFPSFLFSPSLFGGA 1116
              |....|:.:.|:||:     ...::.:|.| |.:::      |||               |.|
Human   890 --RTPAHRDAQAQRRLQLLQNGPTTEEGLAAL-QSILSFSHGQLRTP---------------GKA 936

  Fly  1117 AGMPGA--------ASNAFPAMADENMRH-------------------------VFEREIAKLQQ 1148
            ...|.|        |.|....:|.|...:                         ....|.::::.
Human   937 PVTPLAEPPTPEKDAQNKTEQLASEETENKTGPSRDSANQTTVRIGVYCCPYCSFLSPESSQVRA 1001

  Fly  1149 HQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDI------KLNGQRSSLEH---- 1203
            |...|.|.|.:.:.|       |.|:.|.|...|....:...::      ||....:::|.
Human  1002 HTLSQHAVQPKYRCP-------LCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFTT 1059

  Fly  1204 ---SAGSSSCSKDGERDDAY---PSSLHGRKSEGGG-TP-APPAP-----------PSGPGTGAG 1249
               ||.:.|...:|:....:   |:....:.:||.. || |.|.|           |..|....|
Human  1060 KVLSAPTLSPLDNGQEPPTHGPEPTPSRDQAAEGPNLTPEASPDPLPEPPLASVEVPDKPSGSPG 1124

  Fly  1250 APPTAAP---PTGGASSNSAAPSPLSNSILPPALSSQ-----GEEFAATASPLQRMASITNSLIT 1306
            .||:.||   |...|.:...||        ||.::.:     ||..:|..:|..          :
Human  1125 QPPSPAPSPVPEPDAQAEDVAP--------PPTMAEEEEGTTGELRSAEPAPAD----------S 1171

  Fly  1307 QPPVTPHHST---------PQRPTKAVLPPITQQQFDMFNNL----NTEDIVRRVKEALSQYSIS 1358
            :.|:|...:|         |.||.|..   :.::.|...|.|    |:...:.::|:|....|..
Human  1172 RHPLTYRKTTNFALDKFLDPARPYKCT---VCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSAP 1233

  Fly  1359 QRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPF----------------IRMKMFLEDENA 1407
            .|  ||:             ..|......|.|   ||                |.|:..|....:
Human  1234 AR--GEA-------------GAPPTTTAATDK---PFKCTVCRVSYNQSSTLEIHMRSVLHQTRS 1280

  Fly  1408 VHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQM 1472
            ......|:.: .||:...... .|..:...|...|....|    ..:|.|....|......:.:.
Human  1281 RGTKTDSKIE-GPERSQEEPK-EGETEGEVGTEKKGPDTS----GFISGLPFLSPPPPPLDLHRF 1339

  Fly  1473 QAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAAL 1537
            .|...:..:                .....|..::...|||||.|.    |...|.........|
Human  1340 PAPLFTPPV----------------LPPFPLVPESLLKLQQQQLLL----PFYLHDLKVGPKLTL 1384

  Fly  1538 HHQSMLLTSPGL----PPQHAISLPPSAGGAQ------PGGPGGNQ-GSSNPSNSEKKPMLMPVH 1591
            ...:.:|:.|..    |||     ||.|..|:      |....||: |.|:|      |..:|
Human  1385 AGPAPVLSLPAATPPPPPQ-----PPKAELAEREWERPPMAKEGNEAGPSSP------PDPLP-- 1436

  Fly  1592 GTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIF--------GEAVLG-- 1646
             ..|.|:..:          ||.::...        |.::..|.|::..        .||:.|
Human  1437 -NEAARTAAK----------ALLENFGF--------ELVIQYNEGKQAVPPPPTPPPPEALGGGD 1482

  Fly  1647 -LSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRS----- 1705
             |:.|:..:|.|     :||.:|..|..:..:....:|.:           |.|::.|:|
Human  1483 KLACGACGKLFS-----NMLILKTHEEHVHRRFLPFEALS-----------RYAAQFRKSYDSLY 1531

  Fly  1706 ----TGPNQQDNSSDTSSNDTN-DFYTSSPGPGSV------------------GSGVGGAPP--- 1744
                ..|...|.|.|:...... .|....|..|..                  .|..|..||
Human  1532 PPLAEPPKPPDGSLDSPVPHLGPPFLVPEPEAGGTRAPEERSRAGGHWPIEEEESSRGNLPPLVP 1596

  Fly  1745 --SKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHG 1807
              .:..|..|:|.|.:||:..|....||..|.:|.||:.||||:|.:..||.|.|.:.::....|
Human  1597 AGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEG 1661

  Fly  1808 ---PAGQDNPIPSR----ESTSATPFDPVQ-FRILLQQRLLELHKERMGMSGAPIPYPPYFAAAA 1864
               |.|......|.    .:|.:..|:.|: .:.....:.||..:|.
Human  1662 GSMPTGGGTGGASGCRRCHATFSCVFELVRHLKKCYDDQTLEEEEEE------------------ 1708

  Fly  1865 ILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDD 1929
                                      |..|:|.:.:.:...|:..||:   |....|      ..
Human  1709 --------------------------AERGEEEEEVEEEEVEEEQGLE---PPAGPE------GP 1738

  Fly  1930 LELEGGGHNLSDNESLE--GQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRR-------KPA 1985
            |.....|..||..|:.:  |:|||:|.|......|.....|.:....:.:.|.||       :|:
Human  1739 LPEPPDGEELSQAEATKAGGKEPEEKATPSPSPAHTCDQCAISFSSQDLLTSHRRLHFLPSLQPS 1803

  Fly  1986 APQWV-----------NPAGAVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDDTDSN 2039
            ||..:           ||..|.|:|                    :.|..:.:..|.|     |.
Human  1804 APPQLLDLPLLVFGERNPLVAATSP--------------------MPGPPLKRKHEDG-----SL 1843

  Fly  2040 KPT----DGGNDSDHEH----------AQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNA 2090
            .||    .||.:.:...          .||||..|:.                       .:|:.
Human  1844 SPTGSEAGGGGEGEPPRDKRLRTTILPEQLEILYRWY-----------------------MQDSN 1885

  Fly  2091 TSEQKLKVINEE---KLRMVRV-----------RRLSSTGGG----------------------- 2118
            .:.:.|..|:||   |.|:|:|           .:..||.||
Human  1886 PTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVPSPAVKPPATATPASLPKFNLL 1950

  Fly  2119 -------------------------------------------SSEEMPAPLAPPPP-------- 2132
                                                       .:.|.|.||.||||
Human  1951 LGKVDDGTGREAPKREAPAFPYPTATLASGPQPFLPPGKEATTPTPEPPLPLLPPPPPSEEEGPE 2015

  Fly  2133 -PPAAS-----SSIVSGESTTSSSSS 2152
             ||.||     .|:.:|:.:.||:||
Human  2016 EPPKASPESEACSLSAGDLSDSSASS 2041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	14/70 (20%)
		CUT	1335..1411	CDD:280527	17/95 (18%)
		CUT	1616..1690	CDD:280527	15/84 (18%)
		Homeobox	1749..1801	CDD:278475	22/51 (43%)
ZFHX2	XP_016877205.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910