DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and ABLIM2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_005248071.1	Gene:	ABLIM2 / 84448	HGNCID:	19195	Length:	701	Species:	Homo sapiens

Alignment Length:	479	Identity:	103/479 - (21%)
Similarity:	156/479 - (32%)	Gaps:	141/479 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 FLPGLPAFQFAAAQVAAGGDGRGHYRFADSELQLPPGASMAG--------RLGESLIPKGD---- 864
            :|.|...:..|..|.|...|.....|.:...:...|.:|.:|        :||..::...|
Human   257 YLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIYAKLGGEILDYRDLAAL 321

  Fly   865 PMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPK 929
            |....:.::.|.:|..|:.      :||         |:.|.|        .|.|...:||| |.
Human   322 PKSKAIYDIDRPDMISYSP------YIS---------HSAGDR--------QSYGESPQLLS-PT 362

  Fly   930 PWDKLTEKGRD--SYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAG--GAGGDDSMSEDR 990
            |    ||..:|  ||::....:......:.|....|...|  ||:..|.||  ..|....:|
Human   363 P----TEGDQDDRSYKQCRTSSPSSTGSVSLGRYTPTSRS--PQHYSRPAGTVSVGTSSCLS--- 418

  Fly   991 IAHILSEASSLMKQSSVAQHR--EQERRSHGGEDSHS---NEDSKSPPQSCTSPFFKVENQLKQH 1050
                ||:..|   .:||.:|.  ...|.|..|..:.|   ..|||.||.:        ..|..:|
Human   419 ----LSQHPS---PTSVFRHHYIPYFRGSESGRSTPSLSVLSDSKPPPST--------YQQAPRH 468

  Fly  1051 QHLNPEQAAAQQRERE----REQREREQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPS 1111
            .|: |:........|:    |:.....|.|      ..|::.|...|           |.:...:
Human   469 FHV-PDTGVKDNIYRKPPIYRQHGPVAQSQ------ISKLSGLVSVL-----------SLVVQEA 515

  Fly  1112 LFG----GAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQ 1172
            .:|    |.:..|.||:..            .:.|...|.|..::|::          |.||
Human   516 GYGKRQTGPSPPPAAAARR------------SDGEDGSLDQDNRKQKS----------SWLM--- 555

  Fly  1173 QQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAP 1237
               |.|..|   ....:.|:    ...||.||:|:..........|::.|.....||:
Human   556 ---LKGDAD---TRTNSPDL----DTQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSD------- 603

  Fly  1238 PAPPSGPG----TGAGAPPTAAPP 1257
            |.|..|..    ..|...|..|.|
Human   604 PLPGHGKNGLDQRNANLAPCGADP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	17/70 (24%)
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
ABLIM2	XP_005248071.1	LIM1_abLIM	29..80	CDD:188713
		LIM2_abLIM	85..140	CDD:188714
		LIM3_abLIM	158..209	CDD:188715
		LIM4_abLIM	217..272	CDD:188716	4/14 (29%)
		AbLIM_anchor	282..665	CDD:292800	97/454 (21%)
		VHP	667..701	CDD:280388
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910