DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and cux1a

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_005172775.1	Gene:	cux1a / 797445	ZFINID:	ZDB-GENE-030131-5868	Length:	1495	Species:	Danio rerio

Alignment Length:	1794	Identity:	443/1794 - (24%)
Similarity:	673/1794 - (37%)	Gaps:	554/1794 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 TATSNTNNNNNNNSSS----GNSEKRKKKNNNNNNGQPAVLLAAKDKEIKALLDELQRLRAQEQT 458
            |||:..|..:.:..|.    ..|.:.||....:...|.|.||.....||.||   .:|.:..|..
Zfish    27 TATALANRQDESEQSRKKLIDQSREFKKNTPEDLRKQIAPLLKGFQAEIDAL---SKRSKESEAA 88

  Fly   459 HLVQIQRL--------------EEHLEVKRQHIIRLEARLDKQQINEALAEATALSAAASTNNNN 509
            .|...:||              :..:.|::.|.:..|    .|::.:.|.|   .....|...|.
Zfish    89 FLSVYKRLIDVPDPVSALEAAQQLQVTVRKMHDLETE----NQRLKDTLQE---YEREISEVKNQ 146

  Fly   510 NSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAMLVDS-----EEAEDKPE 569
            ........:||. ..||.:.|.:..:..|      |..|..|.|::....::     .:.|.:||
Zfish   147 EVTIKALKEKLE-QYERSLQAKNTEEAVE------PNLDSSEREERQSKGENLPNNYADKESQPE 204

  Fly   570 DSHHDDDEDEDEDRE----AVNATTTDSNELKIKKEQHSPLDLNVLS--------PNSAIAAAAA 622
            .|.....||.|...:    |:.||..:.:|||.|.::.|....|.:.        .|.....|..
Zfish   205 QSQESRTEDSDVKTQSLQTALEATQAELHELKTKYDEESTAKANEIEAVMTDLERANQRAETAER 269

  Fly   623 AA--------AAAACANDPNKFQALLIERTKALAAE-ALKNGASDALSEDAHHQQQQHHQ----- 673
            .|        :|.......|:.|. ..|..|:|.|| ..|....:.|:||....|....|
Zfish   270 EAGTLREQLTSAGKTMQSSNQIQN-APEMDKSLEAELGAKEREVERLAEDVQRLQASLAQLSETS 333

  Fly   674 --QQHQHQQQHHQQQHLHQQHHHHLQQQPN---------SGSNSNPASNDHHHGHHLHGHGLLHP 727
              |..|.:||...::.|.:|....||.|.:         :..:....|:|||
Zfish   334 TNQISQLEQQLSSKEALLKQLEEKLQDQSDYEEIKRELCTLKSVEHNSSDHH------------- 385

  Fly   728 SSAHHL------------HHQTTESN----SNSSTPTAAGNNNGSNNSSSNTNANSTAQLAAS-L 775
            |||...            |.|.:||.    :||....|.|      .....|...:..:|.|: :
Zfish   386 SSAQDSSKPLEMLLTGKDHSQLSESALKRLANSDFTGAVG------RKLKETTVENPQRLPATPV 444

  Fly   776 ASTLNG-----TKSLMQEDSNGLAAVAMAAHAQH---AAALGPGFL-PGLPA----FQFAAAQVA 827
            .:||.|     :..|:.......:..|.:|:..|   ...:||.|. ||:.:    |...|.::|
Zfish   445 PTTLQGSPPPPSPQLLMRTGTATSESAASANGTHPFSPTGIGPDFFTPGMASVGATFPPLAGKMA 509

  Fly   828 AGG------------------------DGRGHYRFADS-ELQLPPGAS-------MAGRLGESLI 860
            ...                        .|..||...:| ...|||.::       ||....:|
Zfish   510 LNSLLQRQLMQTIYTKALQDPSPSSVLFGPPHYATTNSLSSPLPPQSAGSPEVNGMAPSPSQS-- 572

  Fly   861 PKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELL 925
             :|....::.:||             ||..|:|:|:|.|..||||||:|..|:||||||:|||:|
Zfish   573 -EGAGSTSEGEEM-------------DTAEIARQVKEQLIKHNIGQRVFGHYVLGLSQGSVSEIL 623

  Fly   926 SKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSL------------------IPKKDSGLPQY 972
            ::||||.|||.:|::.:.||..:..|:..::.|:|:                  :||:..|
Zfish   624 ARPKPWSKLTIRGKEPFHKMKHFLSDEQNILALRSIQGRQRENPGQNLNRVFQDVPKRRGG---- 684

  Fly   973 AGRGAGGAGG-------DDSMSEDRIAHILSEASSLMKQSSVAQHREQERRS--HGGEDSH---- 1024
             ..|:...|.       .::.|::.|..||.:|...::........|:.|||  |.|..|:
Zfish   685 -SEGSTRPGNITTRIRTPETGSDEAIKSILEQAKRELQVQKADGVGERHRRSGYHRGSGSYFQIY 748

  Fly  1025 --------SNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQRER-----EREQREREQQQ 1076
                    ||.|.|  |...|          ||.:...|..:::...|.     |:.:||.|.||
Zfish   749 AHSLRLEESNIDLK--PMRMT----------KQFESSQPPSSSSNSDENIRSILEQARREMEAQQ 801

  Fly  1077 RLRHDDQDKMARLYQELIARTP---RETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHV 1138
                             :|..|   ..:..|:.|   ||.|  :.:.|:..:..|
Zfish   802 -----------------VALEPVLKASSMGPTDL---SLLG--SKLLGSPLSTLP---------- 834

  Fly  1139 FEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNG------- 1196
                ...:.|..::          |:.|.|:...    :|.....:...|..|:.|:|
Zfish   835 ----YTPITQSLKK----------PSSSPLLDFH----HGGVKKEMGEVAVSDVGLDGVVPKLGR 881

  Fly  1197 -QRSSL------EH--SAGSS---SCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAG 1249
             ..|.|      ||  |.|.|   ..|:....:||:.......|....|:.||.||.|.......
Zfish   882 LSESGLGGGSWREHWWSTGLSERRGSSQPSVSEDAHSQEDSKEKLPRLGSTAPVAPASSLDYWKD 946

  Fly  1250 APPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHH 1314
            .|.:.:|.:..:..:...||              |.| ...:|||             |..:|..
Zfish   947 WPSSESPYSQSSELSLQMPS--------------GSE-TPQSSPL-------------PSSSPLL 983

  Fly  1315 STPQRPTKAVLPPITQQQFD--MFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDL 1377
            |.| :..|.|:||:|.:|::  |:..::|.|:.::|||.|::..|.||:|||.|||||||||||:
Zfish   984 SLP-KVAKPVVPPLTPEQYEYYMYQEVDTVDLTQQVKEKLAKNGICQRIFGEKVLGLSQGSVSDM 1047

  Fly  1378 LARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASK 1442
            |:|||.|..||||||||||||:::|..|
Zfish  1048 LSRPKHWSKLTQKGREPFIRMQLWLNGE------------------------------------- 1075

  Fly  1443 MQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQA 1507
            :..|.:||           |.|.|.:..:..|:...|   .:....:.:::.::||.:|..:...
Zfish  1076 LGQALMPM-----------PGQTQEITPKTSASCSPA---PESPLSSAEESVKSQQEEQMCRSSV 1126

  Fly  1508 QQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGN 1572
            |:                                                |..|..:|||
Zfish  1127 QE------------------------------------------------PSEASESQPG----- 1138

  Fly  1573 QGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQ 1637
                       .|:.:|:.|...:         ::.||.|::.:|||:.||.|:||.|..||:||
Zfish  1139 -----------TPLPLPLPGQAGL---------SIQEMVAMSAELDTYVITKKVKEVLTDNNLGQ 1183

  Fly  1638 KIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKN-ERREASK 1701
            ::|||::|||:|||||:||::|||||.||:||||||:||||||||..|||:|..:|. |::...|
Zfish  1184 RLFGESILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLSDPRNVEKLMDMKRMEKKAYMK 1248

  Fly  1702 RRRSTGPNQQDNSSDTSSND----TNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRL 1762
            ||.|:........|..|:.|    .:..:.|...|..........|..||.||:.:.|:||||:.
Zfish  1249 RRHSSIGESHSLESGLSAADLTQGASPQHLSQQQPPQQMQPQQQQPQLKKPRVVLAPEEKEALKR 1313

  Fly  1763 AFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSRESTSATPFD 1827
            |:...|||:..|||.||::|.|.|.|:.|||||:|.|:::::
Zfish  1314 AYQQKPYPSPKTIEELASQLNLKTSTVINWFHNYRSRIRREL----------------------- 1355

  Fly  1828 PVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGAS 1892
                       .:|..:...|..|:|...|         |:|  |..|..:..|..:.:.|.|..
Zfish  1356 -----------FIEEIQAAAGEGGSPSARP---------GKS--GGEGENSCDGTESDSTAEGRP 1398

  Fly  1893 GGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDY 1957
            .|                            |::.:..||..|.||...|.   ||:.|....|..
Zfish  1399 SG----------------------------SEERKGFLESPGLGHREEDG---EGEFPSASGTSR 1432

  Fly  1958 EK--VLHK--------SALAAAAAYMSNAVRSSRRKPAA 1986
            .:  ::..        |...||.....|...||.||..|
Zfish  1433 PRGGIIDSLFGIPESISVTNAATTPCRNPKDSSLRKKKA 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	36/68 (53%)
		CUT	1335..1411	CDD:280527	43/75 (57%)
		CUT	1616..1690	CDD:280527	50/73 (68%)
		Homeobox	1749..1801	CDD:278475	27/51 (53%)
cux1a	XP_005172775.1	Tropomyosin	127..371	CDD:278679	57/254 (22%)
		RILP-like	<290..>359	CDD:304877	18/69 (26%)
		Med3	325..>574	CDD:288447	53/270 (20%)
		CUT	580..653	CDD:280527	38/85 (45%)
		CUT	1005..1073	CDD:280527	41/67 (61%)
		CUT	1159..1236	CDD:280527	50/76 (66%)
		Homeobox	1299..1352	CDD:278475	27/52 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574322
Domainoid	1	1.000	116	1.000	Domainoid score	I5926
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2194
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101540at33208
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm26447
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R168
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.030