DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and SIX1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_005973.1	Gene:	SIX1 / 6495	HGNCID:	10887	Length:	284	Species:	Homo sapiens

Alignment Length:	218	Identity:	53/218 - (24%)
Similarity:	77/218 - (35%)	Gaps:	57/218 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1642 EAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASK---RR 1703
            :||:...:|:..||. |....|..| ....|.:: ||||. |:.||..:|.........|   ||
Human    53 KAVVAFHRGNFRELY-KILESHQFS-PHNHPKLQ-QLWLK-AHYVEAEKLRGRPLGAVGKYRVRR 113

  Fly  1704 RSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDP 1768
            :                        .|.|.::..|       ::....|.|:.:..||..:|.:|
Human   114 K------------------------FPLPRTIWDG-------EETSYCFKEKSRGVLREWYAHNP 147

  Fly  1769 YPNVGTIEFLANELGLATRTITNWFHNHRMR------------------LKQQVPHGPAGQDNPI 1815
            ||:......||...||.|..::|||.|.|.|                  ..:|....|.....|:
Human   148 YPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPL 212

  Fly  1816 -PSRESTSATPFDPVQFRILLQQ 1837
             .|.|...:.|..|.|..:||.|
Human   213 MSSSEEEFSPPQSPDQNSVLLLQ 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	16/47 (34%)
		Homeobox	1749..1801	CDD:278475	19/69 (28%)
SIX1	NP_005973.1	SIX1_SD	9..118	CDD:374862	21/92 (23%)
		homeodomain	129..180	CDD:238039	19/50 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..269		17/68 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910