DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and LHX5

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_071758.1	Gene:	LHX5 / 64211	HGNCID:	14216	Length:	402	Species:	Homo sapiens

Alignment Length:	387	Identity:	85/387 - (21%)
Similarity:	132/387 - (34%)	Gaps:	92/387 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1588 MPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKE-------ALLANNIGQKIFGEAVL 1645
            |.||.....|.:.......|.:.|...:.:...:..|.:.|       .|...|...:.||....
Human     1 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCA 65

  Fly  1646 GLSQG-SVSELLSK--PKPWHM----LSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRR 1703
            |.:|| |.|:|:.|  .|.:|:    ..:..::.....:|::.|.|..    :.|::...:|..:
Human    66 GCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKF----VCKDDYLSSSSLK 126

  Fly  1704 ------------RSTGPN----QQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLF 1752
                        ||..|:    .||:..:|.::.::|..|::.......||.....|    |...
Human   127 EGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKRRGP----RTTI 187

  Fly  1753 SEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHR---MRLKQQVPHG------- 1807
            ..:|.|.|:.|||..|.|.....|.||.|.||..|.|..||.|.|   .|:||....|
Human   188 KAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFF 252

  Fly  1808 -------PAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAI 1865
                   |.|  ..:...|...:||:              ..:.:..|...||.....:||..
Human   253 RSPRRMRPLG--GRLDESEMLGSTPY--------------TYYGDYQGDYYAPGSNYDFFAHG-- 299

  Fly  1866 LGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQAL-----------NQAFKEQMSGLDLSMP 1916
                    |.:.|.:.|.::..|....|...|.||           |..|.:.:|..|...|
Human   300 --------PPSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHAADNPRFTDMISHPDTPSP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	18/87 (21%)
		Homeobox	1749..1801	CDD:278475	22/54 (41%)
LHX5	NP_071758.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	7/50 (14%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	13/58 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		12/65 (18%)
		Homeobox	183..237	CDD:395001	22/57 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		13/66 (20%)
		PHA03378	<301..>392	CDD:223065	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910