DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and cux2b

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_009302008.1	Gene:	cux2b / 565530	ZFINID:	ZDB-GENE-081104-176	Length:	1456	Species:	Danio rerio

Alignment Length:	2039	Identity:	461/2039 - (22%)
Similarity:	716/2039 - (35%)	Gaps:	770/2039 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 AVAAVVAGATATNDIED------EQQQQLQQTASGGILESDSDKLLNSSIVAAAITLQQQN---G 137
            :|||.:||  ...:.||      |..::.::.....:||..|..|  .|..|..:.|.|::   .
Zfish    26 SVAAQLAG--RQEESEDSHKHLVELSREFKKNVPEDVLEMVSPVL--KSFQAQVVALSQRSKEAE 86

  Fly   138 SNLLA----NTNTPSPSPPLLSAEQQQQLQSSLQQSGGVGGACLNPKLFFNHAQQMMMMEAAAAA 198
            |..||    ....|.|: |||.|.||:  .:.||:|...|.|.:. ::.....:::..::.|
Zfish    87 SAFLAIYKQLIEAPDPA-PLLEATQQR--LAELQRSAPEGDALIT-EVSDRWRRRLECLDKA--- 144

  Fly   199 AAAALQQQQQQQSPLHSPANEVAIPTEQPAATVATGAAAAAAAAATPIATGNVKSGSTTSNANHT 263
                  :..:::.|:.....||:  |::|             ...||.:|..|:.|..... ||
Zfish   145 ------EHTEEEGPVTVETGEVS--TQKP-------------HMMTPNSTQTVQDGDAPLQ-NH- 186

  Fly   264 NSNNSHQDEEELDDEEEDEEEDEDEDDEEENASMQSNADDMELDAQQETRTEPSATTQQQ----- 323
                    :|.|..||||:.:          |.:....|..||..:.......:|.|:.|
Zfish   187 --------QEPLQGEEEDQSD----------APLPVRLDQAELRIKALQSLLSTARTELQELRCK 233

  Fly   324 HQQQDTEDLEENKDAGEASLNVSNNHNTTDSNNSCS-----RKNNNGGNESEQHVASSAEDDDCA 383
            :.|:..|.|||                      .|:     .|.|...:.:::.|....|
Zfish   234 YDQEKAEKLEE----------------------MCALMANLEKANQRADAAQREVEKLRE----- 271

  Fly   384 NNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNGQPAVLLAAKDKEIKALLDE 448
                ..|...:||              ..:|.||:|.|:.:..:....| ||.:||:||..||:.
Zfish   272 ----QLSGTQSTS--------------KGTGPSEERPKEESERDERLEA-LLFSKDREILRLLEN 317

  Fly   449 LQRLR--AQE--QTHLVQIQRLEEHLEVKRQHI----IRLEARLDKQQINEALAEATALSAAAST 505
            :|||:  .||  .:...||..||..|..|.:.|    .:|::::|.::|...|:...|:..|::
Zfish   318 VQRLQFTLQEVQDSSANQIAELERQLAYKSEAIETLETKLQSQIDYEEIKTELSILKAMKLASA- 381

  Fly   506 NNNNNSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAMLVDSEEAEDKPED 570
             |.::||                         ||.|..           :|:|:|
Zfish   382 -NGSSSQ-------------------------ESAKTA-----------EALLLD---------- 399

  Fly   571 SHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAAAAAAAAAACANDPNK 635
                                         ||...|                           .:|
Zfish   400 -----------------------------KEAFLP---------------------------SHK 408

  Fly   636 FQALLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQP 700
            |   |:::.|.|..           |:|.|.::
Zfish   409 F---LVDKVKVLHN-----------SDDGHSEK-------------------------------- 427

  Fly   701 NSGSNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTP-TAAGNNNGSNNSSSNTN 764
             |...|.||                               .|.||.| |...:...|::.:..|:
Zfish   428 -SNDVSRPA-------------------------------GSYSSPPGTLPIDGRTSSSPAPPTS 460

  Fly   765 ANSTAQLAASLA-STLNGTK------------SLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGL 816
            ..||..|....: |..:|.|            .|.::|.:.:.|...|.:|..||.|.......:
Zfish   461 DTSTHTLPRPFSVSPFSGEKLQDQLLQKQLLSPLFKKDGSSIMAFPTALYAAKAALLSANHSASI 525

  Fly   817 PAFQFAAAQVAAGGDGRGHYRFADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKY 881
            |                     ...|..:|...|.:|..|     .||
Zfish   526 P---------------------ITMETGMPSDQSESGSSG-----GGD----------------- 547

  Fly   882 ANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMH 946
             :..|||..|:.:|:|.|..||||||:|..|:||||||:|||:|::||||.|||.||::.:.||.
Zfish   548 -DDQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMK 611

  Fly   947 AWACDDNAVMLLK--------SLIP-------------------------------KKDSGLPQY 972
            .:..|:..::.|:        |:.|                               |...|.|
Zfish   612 QFLSDEQNILALRTIQVRQRGSITPRIRTPETGSDDAIKSILEQAKKEIQSQRGDCKSSLGCP-- 674

  Fly   973 AGRGAGGAGGDDSMSEDRIAHILSEASSLMK-QSSVAQHREQERRSHGGEDSHSNEDSKSPPQSC 1036
            :||.:.|||   |.|::.|..||.:|...|: |.......|...||...|....::..||...|
Zfish   675 SGRSSTGAG---SSSDEAIKSILEQARREMQAQQQALLEMEVCGRSSASERLSIHDPPKSQASS- 735

  Fly  1037 TSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRET 1101
            |.||.|.|..:...|.|:....:.|.
Zfish   736 TPPFIKQEEGISVPQSLSNPTGSPQT--------------------------------------- 761

  Fly  1102 AFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAK----LQQHQQQQQAAQAQAQF 1162
              |..:.||:.|                  .:|:....:.||.:    ..||...:::|.....|
Zfish   762 --PLSVLSPAAF------------------VQNIIRKVKSEIGEAGTYFDQHWSVERSAAVMGPF 806

  Fly  1163 PNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGR 1227
            .:.|..::                                 |:.|:|..:...|
Zfish   807 TSVSPSLS---------------------------------SSSSTSMPRPWPR----------- 827

  Fly  1228 KSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATAS 1292
             .|.|..|            |....|:||..                  .|.||.|.|......:
Zfish   828 -IENGDCP------------ANGEDTSAPED------------------EPMLSRQVEIKVEPDA 861

  Fly  1293 PLQRMASITNSLIT-QPPVTPHHSTPQRPTKAVLPPITQQQFD--MFNNLNTEDIVRRVKEALSQ 1354
            .:...||.....:: .|...|      |..|..:||:|.:|::  |:..::|.::.|:|||.|::
Zfish   862 SVSSEASCGGGRVSFYPTYIP------RTLKPTVPPLTPEQYEMYMYREVDTLELTRQVKEKLAK 920

  Fly  1355 YSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIA 1419
            ..|.||:|||.|||||||||||:|:|||||..||||||||||||:::|.|:..
Zfish   921 NGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLLDQLG------------ 973

  Fly  1420 PEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQ 1484
                      .|..|:|....|:.::   |:....|......||.||            ::...:
Zfish   974 ----------HGLNQLPNHNHSQEKS---PVTSRSSPSPPASPADAQ------------SSTVLE 1013

  Fly  1485 QVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGL 1549
            .|:.|.:.:::.||.|
Zfish  1014 PVSLALESSKENQQPQ------------------------------------------------- 1029

  Fly  1550 PPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALT 1614
                    ||     ||..|.|          .|..:::|         ...|....:.|:.|::
Zfish  1030 --------PP-----QPLEPHG----------VKSSVMIP---------QQTHTPLGIQELVAMS 1062

  Fly  1615 QDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLW 1679
            .:|||:.||.::||.|..||:||::|||::|||:|||||:|||:|||||.||:||||||:|||||
Zfish  1063 PELDTYAITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLW 1127

  Fly  1680 LSDANNVERLQLLKNERREASKRRR----STGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVG 1740
            |:|.:||::|:.:|...::|..:||    |.|          |.:|:...::....||.....:.
Zfish  1128 LNDPHNVDKLRDVKKMEKKAYLKRRYGLLSPG----------SDSDSPGAHSDCISPGLSALDLC 1182

  Fly  1741 GAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQV- 1804
            ....:||.||:.:.|:|||||.|:..:|||:..|||.||.:|.|.|.|:.|||||:|.|::::|
Zfish  1183 PFSQAKKPRVVLAAEEKEALRKAYLQEPYPSQHTIEMLAAQLNLKTNTVINWFHNYRSRMRREVL 1247

  Fly  1805 --------------PHGPAGQDNPIPSRESTSATP------FDPVQFRILLQQRLLELHKERM-- 1847
                          .:.|....:|:..||.....|      ...:..|..::|...|...|.:
Zfish  1248 MEGLQDNDTDAEHNNYSPLASHSPVSDREDRKQPPSVRNRSVSTIPHRFAVKQETTEPEDEELRP 1312

  Fly  1848 --------GMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQ------ 1898
                    |...:..|           ||||..:|.......:|       :..|:||:
Zfish  1313 RQDKCFSIGAFKSEEP-----------GRSLNLLPDGPQRNSSA-------SHEGEELEKSPEDP 1359

  Fly  1899 ----------------ALNQAFKEQMSGLDLS---MPTLKRERSDDYQDDLELEGGGHNLSDNES 1944
                            :||........||.:|   :|:.....|....:...||....|...|::
Zfish  1360 VSFKASSEPSRSSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPNPPALEPPSINAKLNKN 1424

  Fly  1945 LEGQEPEDKTTDYEKVLHKSALAA 1968
            .  |...:|..:...::|:...||
Zfish  1425 T--QRRNEKMANLNNIIHRLERAA 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	37/68 (54%)
		CUT	1335..1411	CDD:280527	44/75 (59%)
		CUT	1616..1690	CDD:280527	48/73 (66%)
		Homeobox	1749..1801	CDD:278475	28/51 (55%)
cux2b	XP_009302008.1	CENP-Q	206..358	CDD:289839	45/197 (23%)
		CUT	551..620	CDD:280527	37/68 (54%)
		CUT	901..968	CDD:280527	42/66 (64%)
		CUT	1061..1137	CDD:280527	48/75 (64%)
		Homeobox	1190..1243	CDD:278475	28/52 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574321
Domainoid	1	1.000	116	1.000	Domainoid score	I5926
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2194
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101540at33208
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm26447
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000