DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and satb2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_005167766.1	Gene:	satb2 / 563435	ZFINID:	ZDB-GENE-070912-212	Length:	981	Species:	Danio rerio

Alignment Length:	1090	Identity:	210/1090 - (19%)
Similarity:	357/1090 - (32%)	Gaps:	339/1090 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1149 HQQQQQAAQAQAQF-PNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSK 1212
            |..|..:.|..:|. .:..:|..|........:.||.:.:..:.   :.:..|::|.....|...
Zfish    11 HTPQSVSKQQNSQLHTHHCALNELSNHCGTSLESLSSSGSITEQ---SARSPSVQHRTRPFSVLH 72

  Fly  1213 DGERDDAYPSSL--HGRKSEGGGTPAPPAPPSGPGTGAGAPPTA--APPTGGASSNSAAPSPLSN 1273
            :..|..|..|.|  :| :|...|.|......|.|...||.||..  ....||..|.....||
Zfish    73 EAARSPALDSILLING-QSPLNGQPRYRHAISSPYPLAGVPPVVWRGMERGGGESPRLRDSP--- 133

  Fly  1274 SILPPALSSQGEEFAATASPLQRMASITNSLITQPPV---TPHHSTPQRPTKAVLPPI--TQQQF 1333
                   ..:|........|.|::..:.   :...|.   :.|:..||||...::.|:  ..:|.
Zfish   134 -------ERRGSSSPDIGCPPQKLGRLE---LNGSPTGHRSRHNGAPQRPLSGLMIPVFCVVEQM 188

  Fly  1334 D--MFNNLNTED------IVRR-------VKEALSQ--YSISQRLFGESVLGLS----------- 1370
            |  |.::..:.:      :||:       |:.||..  ||.|.......::.:.
Zfish   189 DGGMISDGESREEHAEFVLVRKDILFTQLVETALLALGYSHSSAAQAHGIIKVGRWNPLPIHYLT 253

  Fly  1371 ---QGSVSDLLARPKPWHMLTQKGREPFIRMKMF--LED-----------ENAVHKLVASQYKIA 1419
               :.:|:|:|.  ..:||:|.:     |:::.|  |||           .||:.:|:
Zfish   254 DAPEATVADMLL--DVYHMVTLR-----IQLQSFAKLEDLPSEQWNHATVRNALKELL------- 304

  Fly  1420 PEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQE---------PAQAQHLMQQMQAA 1475
              |.|...:.:....:.|.:.|.:..:|  ....:|..|.||         ..:..:|.|..:.:
Zfish   305 --KEMNQSTLAKECPLSQSMISSIVNSS--YYANVSTAKCQEFGRWYKKYKKIKGDYLWQGREGS 365

  Fly  1476 AMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQ------------QHLQQQQHLAQQQHPHQQHH 1528
            .:.  :::..:|..   ...||:...||....|            .:..:.|:.||.|.|.|...
Zfish   366 EIK--VERDNIADF---CVLAQRPPPHLTALGQLGPLNSAGSLVKGNSGEPQNSAQSQPPPQGQP 425

  Fly  1529 QAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQP-GGPGGNQGSSNPSNSEK--KPMLMPV 1590
            |..::...|||      ||.|..|  :..||.....|| ..||   |..:|..|.:  :..|...
Zfish   426 QPPSSLGQLHH------SPPLRAQ--VPPPPPPAALQPLLAPG---GLLSPQLSPQLVRQQLAMA 479

  Fly  1591 HGTN----AMRSLHQHMSPTVYEMAALTQDLDTH--------------------------DITTK 1625
            |..|    ..|.||||..       ||.|....|                          ||...
Zfish   480 HLINQQLAVSRLLHQHPQ-------ALNQQFLNHPPIPRPSKSGGPGEPGSNPSAAEVSSDIYQL 537

  Fly  1626 IKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWH------MLSIKGREPFIRMQLWLSDAN 1684
            :::.|...::.|.:|.......:||.:||:|.|.:...      ::::|..:.|:.:.
Zfish   538 VRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRSASQSLLVNLKAMQNFLNLP------- 595

  Fly  1685 NVERLQLLKNERREASKRRRSTGPNQQ-------------DNSSD-------------TSSNDTN 1723
            ..||.::.:.||..:.....|..|:..             :.|.|             ..:..||
Zfish   596 ESERDRIYQEERERSMNPPVSLPPSTNPSPGAVRLSQKVWERSIDEQLTPDAWASIWKNKTKITN 660

  Fly  1724 DFYTSSPG-PGSVGSGVGGAPPSKKQRVLFSEEQKEALR-----------------------LAF 1764
            ...|.:|. |      |...|.......::.|.|:|..|                       |.:
Zfish   661 SCKTPNPDLP------VKLEPLVNITSAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRW 719

  Fly  1765 ALDPYP-------NVGTI-EFLA---NELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSR 1818
            ...|.|       |:.|| .||:   .:..:.....:...|:.|:.....:|..|
Zfish   720 KESPSPENRTLWENLCTIRRFLSLPQTDRDMVYEEESRHHHSERLHTVLHLPTDP---------- 774

  Fly  1819 ESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAA 1883
            ::....|..|:              |:...:...|||                       ::||.
Zfish   775 QALHRQPMQPL--------------KDHSPIREDPIP-----------------------SSGAE 802

  Fly  1884 AAAAAVGASGGD----------------ELQALN--QAFKEQM-------------SGLDLSMPT 1917
            ....|...||.:                .|:||.  |:|.:.:             :.|||...|
Zfish   803 ENPQANTGSGNNGPVVSVTKKPRSRTKISLEALGILQSFIQDVGLYPDQEAIHTLSAQLDLPKHT 867

  Fly  1918 L-KRERSDDYQ-------DDLELEGGGHNLS---DNESLEGQEPEDKTTD-YEKVL--HKSALAA 1968
            : |..::..|.       .:|..||||.:::   |.|.|...|..:.:.| :|::.  |:||.|.
Zfish   868 IVKFFQNQRYHVKHHGRLKELGSEGGGVDVAEYRDEELLSSSEDAESSEDGHEEIYSGHESAPAG 932

  Fly  1969 AAAYMSNAVRSSRRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNER 2018
            ||..:|....||.:.....:.: |.|.|...|....:.:::....||.:|
Zfish   933 AANSVSTPALSSVQDENKDKCL-PLGTVRPNSLPPCSSSSSPRDQADYQR 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	22/117 (19%)
		CUT	1616..1690	CDD:280527	16/105 (15%)
		Homeobox	1749..1801	CDD:278475	14/85 (16%)
satb2	XP_005167766.1	SATB1_N	179..276	CDD:211426	18/103 (17%)
		CUTL	307..354	CDD:293165	8/48 (17%)
		CUT	526..602	CDD:280527	15/82 (18%)
		CUT	677..749	CDD:280527	12/71 (17%)
		HOX	823..880	CDD:197696	11/56 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910