DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ct and cux2a

DIOPT Version :9

Sequence 1:NP_524764.1 Gene:ct / 44540 FlyBaseID:FBgn0004198 Length:2175 Species:Drosophila melanogaster
Sequence 2:XP_021332391.1 Gene:cux2a / 561650 ZFINID:ZDB-GENE-031204-9 Length:478 Species:Danio rerio


Alignment Length:537 Identity:164/537 - (30%)
Similarity:244/537 - (45%) Gaps:144/537 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1334 DMF-----NNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGRE 1393
            |:|     ..|:|..:.::||:||...:|.||.||..|||||||||||:|||||||..||::|:|
Zfish    10 DVFLDSDEQELDTLQVTQQVKQALQSRNIGQRAFGHYVLGLSQGSVSDILARPKPWSKLTRRGKE 74

  Fly  1394 PFIRMKMFLEDENAVHKLVA-----------------------------SQYKIAPEKLMRTGSY 1429
            ||:|||.||.||:::..|..                             |:.::..|:|....|.
Zfish    75 PFLRMKHFLSDEHSMRTLSGIQETLRGLAPCVRPTDVSSDQAIRNILDQSRLEMLDEELRSVHSS 139

  Fly  1430 SGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQ 1494
            |.|......:...:|.|...||...|.:.|:|         ||:...:..::        |..|.
Zfish   140 SSSDVSENAIRIILQGAQQQMQTNQSPITLEE---------QMRCGTLDPSI--------QTPAD 187

  Fly  1495 QAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPP 1559
            ..|...|.::.:..:.:|....|:....||                            |..|:  
Zfish   188 FVQGIIQKVKYEIDEDVQPPVSLSSVNQPH----------------------------HGWSV-- 222

  Fly  1560 SAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITT 1624
                            .|....|:            .||     ||||..:.....:|||..||.
Zfish   223 ----------------ENRDAEER------------FRS-----SPTVCGLDLQNLELDTFSITQ 254

  Fly  1625 KIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERL 1689
            ::|:.|:.:||||::|||.||||:|.|||||||.||||..||:||:|.||||.|||.|.::|::|
Zfish   255 RVKKTLIVHNIGQRVFGEEVLGLTQSSVSELLSHPKPWTKLSLKGKENFIRMHLWLRDPHSVQKL 319

  Fly  1690 QLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSE 1754
                |.::::.:|.|.    ::|:.|...:.:..|              |......|:.||:.|.
Zfish   320 ----NAKKKSDQRARL----KRDSQSVCEALECGD--------------VWRVDALKRPRVVLSV 362

  Fly  1755 EQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQ-------QVPH-GPAGQ 1811
            ::|:.|..|:.|:|||:..||:.||.:|||.|.|::|||:|:|.|:::       ||.. .|||.
Zfish   363 QEKQTLFSAYELEPYPSQNTIDRLAAQLGLQTSTVSNWFYNYRSRIRRDGFCEPAQVRRSSPAGL 427

  Fly  1812 DNPIPSRESTSATPFDP 1828
            .....:..:....|.||
Zfish   428 SLLSLASAAVKQAPRDP 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ctNP_524764.1 CUT 886..955 CDD:280527
CUT 1335..1411 CDD:280527 43/80 (54%)
CUT 1616..1690 CDD:280527 44/73 (60%)
Homeobox 1749..1801 CDD:278475 25/51 (49%)
cux2aXP_021332391.1 CUT 16..90 CDD:308148 42/73 (58%)
CUT 246..319 CDD:308148 44/72 (61%)
homeodomain 354..410 CDD:238039 26/55 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101540at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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