DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and pdlim5

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_012817118.2	Gene:	pdlim5 / 548530	XenbaseID:	XB-GENE-854114	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	815	Identity:	142/815 - (17%)
Similarity:	240/815 - (29%)	Gaps:	321/815 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1412 VASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQM-QAA 1475
            :||...:||:  :...:|:.:|: |.|.|:..:.||:|     |......||.|...:|.. |.:
Frog   109 IASPTPVAPK--VSNVAYNKAPK-PFGSATSSKPASIP-----SASSAFTPASASLSIQSSPQPS 165

  Fly  1476 AMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQ 1540
            |:|.                                     |||...|..       :|..||..
Frog   166 ALSL-------------------------------------LAQVGPPPN-------SAPGLHAN 186

  Fly  1541 SMLLTSPGLP----PQHAISLPPSAGG------------AQPG-----GPGGNQGSSNPSNSEKK 1584
            |.......||    .:.|:::|.....            ||.|     |...|||..: .|.:..
Frog   187 SKTTIEGHLPALSATKPAVNVPRQPASYSQTANLYDNEVAQDGAEVRRGQKENQGDKH-QNGKIP 250

  Fly  1585 PMLMPVHGTNAMRSLHQHMSPT---VYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLG 1646
            |...|          .:|:..|   :|..:|
Frog   251 PKRPP----------RKHIVDTYTDIYHTSA---------------------------------- 271

  Fly  1647 LSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQ 1711
            .|..|...|:...:.||..:...:....|:   |:.....|.:                :.|..:
Frog   272 YSDASKKRLIDNTEDWHPRTGTTQSRSFRI---LAQMTGTEHM----------------SEPEPE 317

  Fly  1712 DNSSDTSSNDTN-DFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALD-PYPNVGT 1774
            :......||..| |..||:..|.           .::.|.|  .:..||..:|...| |..:|..
Frog   318 NVQKTKESNICNGDISTSAESPN-----------GREDRKL--SQNAEACSVATQTDVPVEDVTL 369

  Fly  1775 IEFLAN--ELGLATRTITNWFHNHRMRLKQ--------QVPHGPAGQ-DNPIPSRESTSATPFDP 1828
            |..|:.  |..|..|..|.:..:.|...::        |.||..... |||:.|  ...|.||.|
Frog   370 ILDLSERPEPALLEREETYFVSSCRTSPEKSAVQTSPSQSPHRRKSLFDNPLES--LPKAAPFPP 432

  Fly  1829 VQFRIL-LQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGAS 1892
            ...:|| :..::..:.|                 .|::..||...||.:.....::||....|.
Frog   433 ATVQILKVNSQVATIAK-----------------TASVYMRSSMVIPDSLLENSSSAATVINGT- 479

  Fly  1893 GGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDY 1957
             |.::.|     ||:.|                                          ..|...
Frog   480 -GTKINA-----KEKCS------------------------------------------IATQTC 496

  Fly  1958 EKVLHKSALAAAAAYMSNAVRSSRRKP-----------------------AAPQWVNPAGAVTNP 1999
            :|||..::...|..|:::.:.|:.:.|                       .||..:....:..:.
Frog   497 DKVLIPASSPCAVEYIASVIPSTPQVPPRQYIAANPLDTLPKCAPCPPPVLAPLTIQTCKSKVSA 561

  Fly  2000 SAVVAAVAAAAAAAAD---NERIINGVCVMQASEYGRDDTDSNKPT---DGGNDSDHEHAQLEID 2058
            .|.|.|:..|.|..:|   :..:::.:.:   |...:....::|||   .||..:.|.|:.:.::
Frog   562 VAAVTAIVGAQARLSDPFVSRSLLDALLI---SPIPKSSFPTSKPTRKSTGGLYTGHNHSNVSVE 623

  Fly  2059 QRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNATSEQKLKVINEEKLRMVRVRRLSSTGGGSSEEM 2123
               :.|                         ||:.                         ||:.|
Frog   624 ---VPP-------------------------ATAT-------------------------SSKIM 635

  Fly  2124 PAPLAPPPPPPAASSSIVSGESTTSSSSSSNTSSS 2158
            |:....||.....:|.....::..||...:|.:|:
Frog   636 PSSYKSPPSSKPVTSKPTGWQTVPSSGQVTNNASN 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	8/73 (11%)
		Homeobox	1749..1801	CDD:278475	15/54 (28%)
pdlim5	XP_012817118.2	PDZ	10..83	CDD:214570
		PRK14951	<80..216	CDD:237865	32/158 (20%)
		DUF4749	212..320	CDD:406377	23/171 (13%)
		LIM1_ENH	708..759	CDD:188837
		LIM2_Enigma_like	767..818	CDD:188748
		LIM3_ENH	826..880	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910