DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and PITX3

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_005020.1	Gene:	PITX3 / 5309	HGNCID:	9006	Length:	302	Species:	Homo sapiens

Alignment Length:	350	Identity:	71/350 - (20%)
Similarity:	102/350 - (29%)	Gaps:	160/350 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly  1710 QQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSK--KQRVLFSEEQKEALRLAFALDPYPNV 1772
            |:.:.|:.:|       .|.||    ||...|:...|  :||..|:.:|.:.|...|..:.||::
Human    36 QEHSDSEKAS-------ASLPG----GSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDM 89

  Fly  1773 GTIEFLANELGLATRTITNWFHNHRMRLKQQ--------------VPHG---------------- 1807
            .|.|.:|....|....:..||.|.|.:.:::              .|.|
Human    90 STREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYG 154

  Fly  1808 ---PAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRS 1869
               |.....|:.::  |....|:.|....|..|               |:..||...||::
Human   155 NWPPKALAPPLAAK--TFPFAFNSVNVGPLASQ---------------PVFSPPSSIAASM---- 198

  Fly  1870 LAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEG 1934
               :|.||||.|......|        ||.|                                 |
Human   199 ---VPSAAAAPGTVPGPGA--------LQGL---------------------------------G 219

  Fly  1935 GGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGAVTNP 1999
            ||                          ...||.||.                    .:|||:.|
Human   220 GG--------------------------PPGLAPAAV--------------------SSGAVSCP 238

  Fly  2000 SAVVAAVAAAAAAAADNERIINGVC 2024
               .|:.||||||||.:..:....|
Human   239 ---YASAAAAAAAAASSPYVYRDPC 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475	15/51 (29%)
PITX3	NP_005020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		13/45 (29%)
		Homeobox	66..119	CDD:395001	15/52 (29%)
		OAR	258..275	CDD:397759	0/2 (0%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	262..275
		Nuclear localization signal. /evidence=ECO:0000255	268..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910