DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and PAX6

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001355839.1	Gene:	PAX6 / 5080	HGNCID:	8620	Length:	503	Species:	Homo sapiens

Alignment Length:	446	Identity:	90/446 - (20%)
Similarity:	137/446 - (30%)	Gaps:	170/446 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1518 AQQQHPHQQHHQAA-----AAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSN 1577
            :|.||..|....:|     |.|.|....::.||..|   :..:.|.||.|.......||:.|.:.
Human    30 SQSQHAEQGGRSSAAEIKRAVAGANRLPALSLTCGG---RTCLWLKPSPGSDSHVCTGGHSGVNQ 91

  Fly  1578 PSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGE 1642
            ...       :.|:|.....|..|                       ||.|  ||::..:.....
Human    92 LGG-------VFVNGRPLPDSTRQ-----------------------KIVE--LAHSGARPCDIS 124

  Fly  1643 AVLGLSQGSVSELLS--------KPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNE---- 1695
            .:|.:|.|.||::|.        :|:     :|.|.:|.:      :....|.::...|.|
Human   125 RILQVSNGCVSKILGRYYETGSIRPR-----AIGGSKPRV------ATPEVVSKIAQYKRECPSI 178

  Fly  1696 -RREASKRRRSTGPNQQDNSSDTSS---------------------------NDTNDFYTSSPG- 1731
             ..|...|..|.|....||....||                           |.....:.:.||
Human   179 FAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGW 243

  Fly  1732 -PGSVGSGVGGAPPS------------------------------------KKQRVLFSEEQKEA 1759
             |   |:.|.|.|..                                    ::.|..|::||.||
Human   244 YP---GTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEA 305

  Fly  1760 LRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMR---------LKQQVPHGPAGQDNPI 1815
            |...|....||:|...|.||.::.|....|..||.|.|.:         .::|..:.|    :.|
Human   306 LEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTP----SHI 366

  Fly  1816 PSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPY--FAAAAILGRS 1869
            |...|.|.:.:.|:                       |.|..|.  |.:.::|||:
Human   367 PISSSFSTSVYQPI-----------------------PQPTTPVSSFTSGSMLGRT 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	16/81 (20%)
		Homeobox	1749..1801	CDD:278475	20/60 (33%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	32/166 (19%)
PAX6	NP_001355839.1	Homeobox	295..348	CDD:395001	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910