DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Unc-115b

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_731390.1	Gene:	Unc-115b / 41178	FlyBaseID:	FBgn0260463	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	99/525 - (18%)
Similarity:	166/525 - (31%)	Gaps:	133/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 LNVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSA-----------EDDDCANNNTNTS------ 390
            |...:||:...:...|::..:..|:..|.::..||           |.....|....||
  Fly   282 LQAGDNHHFHPTCARCTKCGDPFGDGEEMYLQGSAIWHPRCGPGPSESGIILNGGGGTSSVVGGA 346

  Fly   391 NNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNGQPAVLLAAKDKEIKA-----LLDELQ 450
            :|.|.::|..       :..|||..||...:....:.||.   |.::..|..:.     :|.|..
  Fly   347 SNGNFTDTEC-------DRMSSSALSEMYIRSRTPSFNGS---LYSSSRKHYRTVSPGLILREYG 401

  Fly   451 RLRAQEQTHLVQIQRLEEHLEVKRQHIIRLEARLDKQQINEALAEATALSAAASTNNNN-----N 510
            |..|::.:.:.....|.:.....|:.|...:........:...:.||..|.|.|...:.     :
  Fly   402 RPNAEDISRIYTYSYLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRPH 466

  Fly   511 SQSSDNNKKL----NTAAERPMDASSNADLP------ESTKAPVPAEDDEEDEDQ----AMLVDS 561
            |::....|.|    .:...||.....|.:.|      .:.|.|.|.|..:.:.|.    ......
  Fly   467 SRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSHYPAAKKPPPGEQPKIERDDFPAPPYPYTD 531

  Fly   562 EEAEDKPEDSHH----DDDEDEDEDREAVNATTTDSNE---LKIKKEQHSPLDLNVLSPNSAIAA 619
            .|...:..|::.    .|||||:.:....|....:..|   |:.:.||...|       ||.|
  Fly   532 PERRRRYSDTYKGVPASDDEDENVENGKPNGKVKNGEEQQRLQREAEQLEKL-------NSGI-- 587

  Fly   620 AAAAAAAAACAND-----------PNKFQALLIERTKALAAEALKN-------GASDALSEDAHH 666
                  .:|.|.|           .|........||.:.:.|.|..       |||.  |.:..|
  Fly   588 ------GSAIAKDLKEHAKYRKWKQNNLDPRNASRTPSASKEPLYKLRYESPIGASP--SRNLDH 644

  Fly   667 QQQQHHQQQHQHQQQHH--------QQQHLHQQHHHHLQQQPNSGSNS-------NPASNDHHHG 716
            |:..:..:.......:.        .....:..|.:....:|..|..:       |..|:|..:|
  Fly   645 QKPFYEDEMFDRSTSYRGSLGKSLGNAPSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYG 709

  Fly   717 HHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANSTAQLAASL--ASTL 779
                  ||               .:...||..:.|.:..|.:|.  |..:..|.:...|  :||.
  Fly   710 ------GL---------------GDKTHSTDLSCGKSEASVDSI--TEGDRRALMGGDLPASSTY 751

  Fly   780 NGTKS 784
            :|..|
  Fly   752 SGALS 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
Unc-115b	NP_731390.1	LIM1_abLIM	46..97	CDD:188713
		LIM2_abLIM	102..157	CDD:188714
		LIM3_abLIM	211..262	CDD:188715
		LIM4_abLIM	270..326	CDD:188716	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910