DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and LIMK2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001026971.1	Gene:	LIMK2 / 3985	HGNCID:	6614	Length:	686	Species:	Homo sapiens

Alignment Length:	659	Identity:	113/659 - (17%)
Similarity:	192/659 - (29%)	Gaps:	287/659 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  1322 KAVLPPITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHM 1386
            :.||.|       ||..|:||.    |:|.| .||::                  |::.|
Human   106 EVVLAP-------MFERLSTES----VQEQL-PYSVT------------------LISMP----- 135

  Fly  1387 LTQKGREPFI--------------------RMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSG 1431
            .|.:||..|.                    ||.:...:.||:|         ..::::   ..:|
Human   136 ATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIH---------PGDRIL---EING 188

  Fly  1432 SPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQA 1496
            :|                    :..|:::|...|  :.|..|  .:...::...|:|...|.:..
Human   189 TP--------------------VRTLRVEEVEDA--ISQTSQ--TLQLLIEHDPVSQRLDQLRLE 229

  Fly  1497 QQAQQHLQQQAQQHLQQQQHLAQQQHPH-------QQHHQAAAAAAALHHQSMLLTSPGLPPQHA 1554
            .:...|:|...              |||       :::.:......:|...:.:..|||
Human   230 ARLAPHMQNAG--------------HPHALSTLDTKENLEGTLRRRSLRRSNSISKSPG------ 274

  Fly  1555 ISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDL-- 1617
                                   || |.|:|:|.   ..:..||.....|.:..:......||
Human   275 -----------------------PS-SPKEPLLF---SRDISRSESLRCSSSYSQQIFRPCDLIH 312

  Fly  1618 --------------DTHDITTKI---KEALLANNIGQKIFGEAV--------------LG----- 1646
                          .||..|.|:   ||.:..:...||.|...|              :|
Human   313 GEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKD 377

  Fly  1647 ---------LSQGSVSELLSK--PKPW-----------------HMLSIKGREPFIRMQLWLSDA 1683
                     :..|::.:.|..  |.||                 |.:.|..|:        |:..
Human   378 KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD--------LNSH 434

  Fly  1684 NNVERL------------QLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVG 1736
            |.:.:|            :|:..||:.|...:.:|      .......||....||
Human   435 NCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT------KKRTLRKNDRKKRYT--------- 484

  Fly  1737 SGVGGAPPSKKQRVLFSEEQKEALRL-AFAL-----------DPYPNVGTIEFLANELGLATRTI 1789
              |.|.|......:|..:...|.:.: :|.:           ||.....|::|     ||..:..
Human   485 --VVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDF-----GLNVKLF 542

  Fly  1790 TNWFHNH--------------RMRLKQQVPHGPAGQ-----DNPIPSRESTSAT-PFDPVQFR-- 1832
            ...|...              |:..:.:.|.|.||:     |:..|.|.....| .:||.:.|
Human   543 WEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGPGCADDEGPVRRQGKVTIKYDPKELRKH 607

  Fly  1833 ILLQQRLLE 1841
            :.|::.:||
Human   608 LNLEEWILE 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	21/95 (22%)
		CUT	1616..1690	CDD:280527	24/151 (16%)
		Homeobox	1749..1801	CDD:278475	11/77 (14%)
LIMK2	NP_001026971.1	LIM	<15..44	CDD:295319
		LIM2_LIMK2	46..104	CDD:188849
		PDZ	131..215	CDD:278991	18/124 (15%)
		PKc_like	316..570	CDD:328722	45/283 (16%)
		PP1_inhibitor	564..686	CDD:283108	15/53 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910