DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and LIMK1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_002305.1	Gene:	LIMK1 / 3984	HGNCID:	6613	Length:	647	Species:	Homo sapiens

Alignment Length:	368	Identity:	73/368 - (19%)
Similarity:	116/368 - (31%)	Gaps:	125/368 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1540 QSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMS 1604
            :.:|..|||....|.::|.     :.|....|.:|.|        ..:.|.||.....:.|.|
Human   148 EQILPDSPGSHLPHTVTLV-----SIPASSHGKRGLS--------VSIDPPHGPPGCGTEHSH-- 197

  Fly  1605 PTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKG 1669
                  ....|.:|...::..:|.::   ::|.:|                         |.|.|
Human   198 ------TVRVQGVDPGCMSPDVKNSI---HVGDRI-------------------------LEING 228

  Fly  1670 ----REPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSP 1730
                ..|...:.|.:.:.:.:.:|.|   |...........||.....||..        ||.|
Human   229 TPIRNVPLDEIDLLIQETSRLLQLTL---EHDPHDTLGHGLGPETSPLSSPA--------YTPS- 281

  Fly  1731 GPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLAN---ELGLATRTITNW 1792
              |..||               |..||..|| :.::|..|..|::...|:   :|| .:.::...
Human   282 --GEAGS---------------SARQKPVLR-SCSIDRSPGAGSLGSPASQRKDLG-RSESLRVV 327

  Fly  1793 FHNHRMRLKQQVPHGPA------GQDNPIPSRES------TSATPFDPVQFRILLQQ----RLLE 1841
            ...||:.....:.||..      ||...:..||:      .....||....|..|::    |.||
Human   328 CRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE 392

  Fly  1842 ----------LHKE-RMGMSGAPIPYPPYFAAAAILGRSLAGI 1873
                      |:|: |:.           |....|.|.:|.||
Human   393 HPNVLKFIGVLYKDKRLN-----------FITEYIKGGTLRGI 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	9/77 (12%)
		Homeobox	1749..1801	CDD:278475	13/54 (24%)
LIMK1	NP_002305.1	LIM1_LIMK1	5..77	CDD:188846
		LIM	84..138	CDD:295319
		PDZ	165..255	CDD:278991	22/141 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..319		19/85 (22%)
		STKc_LIMK1	345..611	CDD:271123	20/91 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910