DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and ABLIM1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_006717900.1	Gene:	ABLIM1 / 3983	HGNCID:	78	Length:	788	Species:	Homo sapiens

Alignment Length:	728	Identity:	129/728 - (17%)
Similarity:	209/728 - (28%)	Gaps:	258/728 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1077 RLRHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFER 1141
            |:..:.:|.:.:|..:.::.:|:||.|.|
Human   136 RVTFNGRDCLCQLCAQPMSSSPKETTFSS------------------------------------ 164

  Fly  1142 EIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAG 1206
                        ..|.......|..:|:||.:|...|..........     |.|:..|.:   |
Human   165 ------------NCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKV-----LTGEYISKD---G 209

  Fly  1207 SSSCSKD-----GERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSA 1266
            :..|.||     |.:.:|....:.|:..|.|.....|                          |.
Human   210 APYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHP--------------------------SC 248

  Fly  1267 APSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTPQRPTKAVLPPITQQ 1331
            |.....|.:.     ::|||.           .:..|.:..|.......|.:   |..||.|.:.
Human   249 ARCSRCNQMF-----TEGEEM-----------YLQGSTVWHPDCKQSTKTEE---KLRLPNIRRS 294

  Fly  1332 QFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARP------KPWHMLTQK 1390
            ..|.|   .::.::||...:.|             |..::.|...:.:||      .|.|.:..|
Human   295 SSDFF---YSKSLIRRTGRSPS-------------LQPTRTSSESIYSRPGSSIPGSPGHTIYAK 343

  Fly  1391 GREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASL-PMQKMM 1454
            .....:..|    |..|:.| |.:.|.|....|:   :|  .|....|...|.:..|| ...:.:
Human   344 VDNEILDYK----DLAAIPK-VKAIYDIERPDLI---TY--EPFYTSGYDDKQERQSLGESPRTL 398

  Fly  1455 SELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQ 1519
            |.....|  ..|.:..:|...:.|.......|...........::.||.
Human   399 SPTPSAE--GYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHF---------------- 445

  Fly  1520 QQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLP---------PSAGGAQPGGPGGNQGS 1575
                    |:....:..:...|.|.|| .|.|.|:.|.|         |...|.:|     :.|.
Human   446 --------HRPELLSPGVQRLSYLRTS-SLSPTHSDSRPNPPFRHHFIPHIKGNEP-----SSGR 496

  Fly  1576 SNPSNSEKKPMLMPVHGTNAMRSLHQHM---------SPTVYEMAALTQDLDTHDITTKIKEALL 1631
            ::|  ...:|...|:..|.|....|.|:         .|.:|:.         ||      .|.|
Human   497 NSP--LPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQ---------HD------AAAL 544

  Fly  1632 ANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIK----------------------GREPFI 1674
            |   .|....|.::..|:...::   .|.|.....|:                      |||.
Human   545 A---AQSKSSEDIIKFSKFPAAQ---APDPSETPKIETDHWPGPPSFAVVGPDMKRRSSGREE-- 601

  Fly  1675 RMQLWLSDANNVERLQL----------------LKNERREASKRRRSTGPNQQDNSSDTSSNDTN 1723
                  .|...:.|.||                ||.|..:.|:.|.|...::.|:..:::|:..:
Human   602 ------DDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERSSLLASRYDSPINSASHIPS 660

  Fly  1724 DFYTSSPGPGSVG 1736
            ....|.||.|..|
Human   661 SKTASLPGYGRNG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	14/81 (17%)
		CUT	1616..1690	CDD:280527	16/95 (17%)
		Homeobox	1749..1801	CDD:278475
ABLIM1	XP_006717900.1	LIM1_abLIM	39..90	CDD:188713
		LIM2_abLIM	95..150	CDD:188714	3/13 (23%)
		LIM3_abLIM	166..217	CDD:188715	13/58 (22%)
		LIM4_abLIM	225..280	CDD:188716	13/96 (14%)
		AbLIM_anchor	318..752	CDD:292800	82/429 (19%)
		VHP	753..788	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910