DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Lim3

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	154/742 - (20%)
Similarity:	214/742 - (28%)	Gaps:	291/742 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1453 MMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHL 1517
            ||..||...|....|                    |.|.|.|...|.|.|..||.|..|||||||
  Fly     1 MMQTLKPPPPLHHHH--------------------QHQHQLQHPPQQQPHPHQQLQHPLQQQQHL 45

  Fly  1518 AQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSE 1582
            :...: ||||.      ..:|.|.          |....|||:...:...| |..|...:|.
  Fly    46 SAMDN-HQQHQ------PHIHQQQ----------QQQQQLPPTPQASHLVG-GQQQQQQHPH--- 89

  Fly  1583 KKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGL 1647
                             |.|::            :|..|...::..||::.|...    ||.:..
  Fly    90 -----------------HNHLA------------VDQDDPNPELVLALISRNRAL----EATIPK 121

  Fly  1648 SQGSVSELLSK------PKPWHMLSIKGRE--------PFIRM-QLWLSDANNVERLQLLKNERR 1697
            ..|....:|.:      .:.||...::..|        .|.|. ||:..:       ...|....
  Fly   122 CGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKE-------DFFKRYGT 179

  Fly  1698 EASKRRRSTGPNQ-----QDN----------SSDTSSNDTNDFY---------------TSSPGP 1732
            :.|.......|.|     |||          ....:.|..::||               ..:.|.
  Fly   180 KCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGL 244

  Fly  1733 GSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHR 1797
            ...|| :.|..|:|:.|...:.:|.|.|:.|:...|.|.....|.|:.:.||..|.:..||.|.|
  Fly   245 YLDGS-LDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRR 308

  Fly  1798 ---MRLKQQVPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPY 1859
               .|||:.     ||:     :|.|.        .||               .|.|...|....
  Fly   309 AKEKRLKKD-----AGR-----TRWSQ--------YFR---------------SMKGNCSPRTDK 340

  Fly  1860 FAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSD 1924
            |.                               ..|||:....:|...    |||        :|
  Fly   341 FL-------------------------------DKDELKVDYDSFSHH----DLS--------ND 362

  Fly  1925 DYQD-DLELEGGGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRRKPAAPQ 1988
            .|.. :|.|:            ||..|......|   :|.|:..      |....|||..|
  Fly   363 SYSTVNLGLD------------EGASPHSIRGSY---MHGSSSP------SQYPPSSRSPP---- 402

  Fly  1989 WVNPAG------------AVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDDTDSNKP 2041
               |.|            ..||   :..||.::..|:..:.|:                ..||..
  Fly   403 ---PVGQGHTFGSYPDNIVYTN---IDQAVGSSLHASKAHHRL----------------HSSNNV 445

  Fly  2042 TDGGNDSDHEHAQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLDNEDNATSEQKLKVINEEKLRM 2106
            :|..|||..       ||.:.:    .....|.....|||.|..:.:|..:.......|..
  Fly   446 SDLSNDSSP-------DQGYPD----FPPSPDSWLGDSGSTNTTSANNNANNNSSSSHNNN---- 495

  Fly  2107 VRVRRLSSTGGGSS----EEMPAPLAP 2129
                  :|:||||.    ...|.|.||
  Fly   496 ------NSSGGGSGGVSVSTAPNPSAP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	16/88 (18%)
		Homeobox	1749..1801	CDD:278475	17/54 (31%)
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	9/57 (16%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	9/54 (17%)
		Homeobox	259..312	CDD:278475	16/52 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910