DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and ONECUT1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_004489.1	Gene:	ONECUT1 / 3175	HGNCID:	8138	Length:	465	Species:	Homo sapiens

Alignment Length:	333	Identity:	90/333 - (27%)
Similarity:	134/333 - (40%)	Gaps:	86/333 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1516 HLAQQQHPHQQHHQAAAAAAAL--------HHQSML-------LTSP--------GLPPQHAISL 1557
            |.:||..||..|..||.....:        ||.:||       ||..        ||||.|
Human   191 HNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHH---- 251

  Fly  1558 PPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDI 1622
            |.:...||  |.|...|::.    |..|.:.....:|...|             ...::::|.::
Human   252 PHAHLNAQ--GHGQLLGTAR----EPNPSVTGAQVSNGSNS-------------GQMEEINTKEV 297

  Fly  1623 TTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVE 1687
            ..:|...|...:|.|.||.:.||..|||::|:||..||||..|. .|||.|.||..||.:. ..:
Human   298 AQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRRMWKWLQEP-EFQ 360

  Fly  1688 RLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLF 1752
            |:..|   |..|.||:      :|::..|.                      |..|  ||.|::|
Human   361 RMSAL---RLAACKRK------EQEHGKDR----------------------GNTP--KKPRLVF 392

  Fly  1753 SEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMR-LKQQVPHGPAGQDNPIP 1816
            ::.|:..|...|..:..|:......::.:|||...|::|:|.|.|.| |.:....|.:...|
Human   393 TDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGN--- 454

  Fly  1817 SRESTSAT 1824
             ..|:|:|
Human   455 -SSSSSST 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	29/73 (40%)
		Homeobox	1749..1801	CDD:278475	15/52 (29%)
ONECUT1	NP_004489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..141
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..290		5/42 (12%)
		CUT	290..362	CDD:396794	28/73 (38%)
		HOX	385..440	CDD:197696	17/56 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..465		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910