DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and vnd

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_476786.2	Gene:	vnd / 31003	FlyBaseID:	FBgn0261930	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	1018	Identity:	201/1018 - (19%)
Similarity:	285/1018 - (27%)	Gaps:	448/1018 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   999 SSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAA---- 1059
            |:.::::...:.|::||.:..|..|..:  ..:.|||..:              ::|...|
  Fly     4 SASLERTPSKRDRDRERDNSSGLGSAGS--LPASPQSAIT--------------VSPSSPATPKR 52

  Fly  1060 -------AQQREREREQRE-----REQQQRLRHD-DQDKMARLYQELIARTPRETAFPSFLFSPS 1111
                   :.:|:||||.||     :|:|:|...| |.::.|.::.......|..|:..|.|....
  Fly    53 PLRTSTPSLERKREREDREDREDRKERQERHERDRDHERFAAVFSTASTTVPTNTSSSSGLAPEQ 117

  Fly  1112 L--------FGGAAGM-------------------------------------------PGAASN 1125
            |        |.|..|:                                           |.|..|
  Fly   118 LRIPTGAAAFSGFPGLHSMSSLMLPSSAAVAAAAAAPFLPWSPILLPPWNHALLPAAFYPAALRN 182

  Fly  1126 AFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAK 1190
            |.|.:.|           ||:...|        ::.| :.|.::.|:      ..:|..|||||.
  Fly   183 ALPGLFD-----------AKVPSSQ--------RSGF-HISDILNLE------GSELKNAAAAAA 221

  Fly  1191 DIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPP---SGPGTGAGAPP 1252
            ....:|...| .|||..|:....|:.....||:|       ..|||..:..   :|.|||.||
  Fly   222 AAAHHGSDLS-HHSASESTSGHRGQGSHTSPSAL-------SPTPAGVSADEHHNGSGTGGGA-- 276

  Fly  1253 TAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTP 1317
                  |.|..:|                                            .|.||:.|
  Fly   277 ------GEADHHS--------------------------------------------TTEHHAPP 291

  Fly  1318 QRPTKAVLPPITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPK 1382
            ..|         |||                                                 .
  Fly   292 SHP---------QQQ-------------------------------------------------H 298

  Fly  1383 PWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAAS 1447
            |.|   |:...|              |.|                       :||
  Fly   299 PHH---QQHHHP--------------HLL-----------------------LPQ---------- 313

  Fly  1448 LPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQ-QQAQQHL 1511
                              ||              .||.||.......|:.:||.|.. ..|..||
  Fly   314 ------------------QH--------------HQQAVAPLPLAHHQSGEAQSHAHANAAAAHL 346

  Fly  1512 QQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSS 1576
                 ||.        |.||||||....|.:    |.||...            ||..|
  Fly   347 -----LAS--------HNAAAAAAVAAGQYL----PNLPKNF------------PGSFG------ 376

  Fly  1577 NPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAAL-----------TQDLDTHDITTKIKEAL 1630
                             :.|.|.| ||:.|:.:.:..           ||...:.|.|:.:...:
  Fly   377 -----------------DEMSSYH-HMAQTMLQHSGRSAWIKENELYGTQQPASPDSTSPVTSEV 423

  Fly  1631 LANNIGQKIFGEAVL-----GLSQGSVSELLSKPKPWHML------SIKGREPFIRMQLWLSDAN 1684
            ....||........|     ..|:.:.|:.||.....|.|      ...|..|....   |.:.|
  Fly   424 SYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHA---LHNNN 485

  Fly  1685 NVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSN------DTNDFYTSSPGPGSVGSGVGGAP 1743
            |        |.....:...::.|.|...:..|.|.|      |.:|...:....|...:|..|.|
  Fly   486 N--------NTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDGLP 542

  Fly  1744 PSK-KQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQV--- 1804
            ..| |:||||::.|...|...|....|.:....|.||:.:.|....:..||.|||.:.|:..
  Fly   543 NKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTKRAQNEK 607

  Fly  1805 ---------------PHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMS---G 1851
                           ||.|:..  |.|.|.:.      ||         |:...|..:|.|   |
  Fly   608 GYEGHPGLLHGHATHPHHPSAL--PSPRRVAV------PV---------LVRNGKPCLGDSSKLG 655

  Fly  1852 APIPYPPYFAAAAI---LGRSLAGIPGAAAAAGAAAAAAAVGA 1891
            |.........|.|:   ....|..:.||||...||||||.:.|
  Fly   656 ADCVSVSSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHA 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	5/75 (7%)
		CUT	1616..1690	CDD:280527	16/84 (19%)
		Homeobox	1749..1801	CDD:278475	17/51 (33%)
vnd	NP_476786.2	Homeobox	548..601	CDD:278475	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910