DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Pbx1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001128334.1	Gene:	Pbx1 / 304947	RGDID:	1308213	Length:	430	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	102/577 - (17%)
Similarity:	186/577 - (32%)	Gaps:	192/577 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1462 PAQAQHLMQQMQAAAMSAAMQQ------QQVAQAQQQAQQAQQAQQHLQQQAQQ---------HL 1511
            |..:|||.............:|      ||:.....|:....||::|.....:.         .:
  Rat    20 PGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEI 84

  Fly  1512 QQQQHL----AQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGN 1572
            :::..|    ||::.|....        .:...:|||......|:.......:|..|...|..|:
  Rat    85 KEKTVLSIRGAQEEEPTDPQ--------LMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGS 141

  Fly  1573 QGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQ 1637
            ..|...|:...|        .:.:|.:: |.....||.|.       ::.||.:...
  Rat   142 DNSVEHSDYRAK--------LSQIRQIY-HTELEKYEQAC-------NEFTTHVMNL-------- 182

  Fly  1638 KIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGRE-PFIRMQLWLSDANNVERLQLLKNERREASK 1701
                     |.:.|.:..:|..:...|:||..|: ..|:|||   ..:..|.:.:|::...:|.:
  Rat   183 ---------LREQSRTRPISPKEIERMVSIIHRKFSSIQMQL---KQSTCEAVMILRSRFLDARR 235

  Fly  1702 RRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFAL 1766
            :||        |.:..::...|:::.|                                   ...
  Rat   236 KRR--------NFNKQATEILNEYFYS-----------------------------------HLS 257

  Fly  1767 DPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSRESTSATPFDPVQF 1831
            :|||:....|.||.:.|:....::|||.|.|:|.|:.:  |...::..|
  Rat   258 NPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNI--GKFQEEANI---------------- 304

  Fly  1832 RILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGGDE 1896
                                       |.|..|:...::       :|.|:.|.:.:...|.|.
  Rat   305 ---------------------------YAAKTAVTATNV-------SAHGSQANSPSTPNSAGS- 334

  Fly  1897 LQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYEKVL 1961
                :.:|....|| ||.| :::....|.||.   .:.|.:..|..::|  :....:|..|
  Rat   335 ----SSSFNMSNSG-DLFM-SVQSLNGDSYQG---AQVGANVQSQVDTL--RHVISQTGGY---- 384

  Fly  1962 HKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGA---VTNPSAVVAAVAAAAAAAAD 2015
             ...|||:..|             :||.::..|.   .|.||:|.:......:..:|
  Rat   385 -SDGLAASQMY-------------SPQGISANGGWQDATTPSSVTSPTEGPGSVHSD 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	14/74 (19%)
		Homeobox	1749..1801	CDD:278475	13/51 (25%)
Pbx1	NP_001128334.1	PBC	40..232	CDD:397732	42/235 (18%)
Pbx1	NP_001128334.1	homeodomain	234..294	CDD:238039	19/102 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910