DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Cux2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_038945174.1	Gene:	Cux2 / 288665	RGDID:	1305967	Length:	1522	Species:	Rattus norvegicus

Alignment Length:	2046	Identity:	455/2046 - (22%)
Similarity:	712/2046 - (34%)	Gaps:	694/2046 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SENSDTAAAAATAAAVAAVVAGATATNDIEDEQQQQLQQTASGGILESDSDKLLNSSIVAAAITL 132
            :|.....|.....|..|....|..|...::..:.|                |.|||  ||:.:::
  Rat     3 AEGGPRGARGPRPARAARATRGPRARRRLDLRRLQ----------------KELNS--VASELSV 49

  Fly   133 QQQNGSNLLANTNTPSPSPPLLSAEQQQQLQSSLQQSGGVGGACLNPKLFFNHAQQMMMMEAAAA 197
            .|:...:          ||..| .|.:::.:.::.:  |: .|.:.|.|....|:.:.:.:.:..
  Rat    50 PQEESEH----------SPKRL-IELRREFKKNVPE--GI-RAMVAPVLKSFQAEVVALSKRSQE 100

  Fly   198 AAAAALQQQQQQ-QSPLHSPANEVA--------IPTEQPAATVATGAAAAAAAAATPIATGNVKS 253
            |.||.|...:|. ::|...|:.|||        .|:..|:.........:......|.:......
  Rat   101 AEAAFLSVYKQLIEAPDPVPSVEVARTLDDRLQRPSFHPSGQRLRDVHISWKRCPEPPSAREQNE 165

  Fly   254 GSTTSNANHTNSNNSH----QDEEELDDEEEDEEEDEDEDDEEENASMQSNADDMELDAQQETRT 314
            |  |....||.:|.:|    :|....|...:.:|.:..:..:|.:.::.:...    :|:::.:.
  Rat   166 G--TCPTGHTPANGNHLPGPEDTLVTDTLLQKDEAERQKGLQEVHVTLAARLG----EAEEKIKV 224

  Fly   315 EPSATTQQQHQQQDTEDLEENKDAGEASLNVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSAED 379
            ..||....|     ||.||..:                               :.::..||.|
  Rat   225 LHSALKATQ-----TELLELRR-------------------------------KYDEEAASKA-- 251

  Fly   380 DDCANNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNGQPA-----------V 433
            |:.....||....|..:..|.....:.....:|..:|.:....:.....|:..           .
  Rat   252 DEVGLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPGGEKVSFALCSGPRLEA 316

  Fly   434 LLAAKDKEIKALLDELQRLRAQ----EQTHLVQIQRLEEHLEVKRQHIIRLEARLDKQ-QINEAL 493
            .||:||:||..||.:.|:||..    |:....||..||..|..|.:.|.:|:.:|:.| ...|..
  Rat   317 ALASKDREILRLLKDAQQLRHSLQELEEVSANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIK 381

  Fly   494 AEATALSAAASTNNNNNSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAML 558
            .|.:.|.|                .||         |||...||:.                  .
  Rat   382 TELSILRA----------------MKL---------ASSTCSLPQP------------------C 403

  Fly   559 VDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAAAAA 623
            ..|.:|..||:|                        .|.:.|:...|.
  Rat   404 FPSPQALGKPDD------------------------PLLMAKDAFFPT----------------- 427

  Fly   624 AAAAACANDPNKFQALLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHL 688
                         |.||:|:...||:........|::                        :..|
  Rat   428 -------------QKLLLEKPALLASPEEDPSEDDSI------------------------KGSL 455

  Fly   689 HQQHHHHLQ-------QQPNSGSNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSST 746
            ..:..:..|       :.|.|.|.:.|               ||.||    |......:.|.|..
  Rat   456 GMEPSYPPQLPPPPGPEDPLSPSPTQP---------------LLGPS----LGPDGPRTFSLSPF 501

  Fly   747 PTAAGNNNGSNNSSSNTNANSTAQLAASLASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPG 811
            |:.|....                    ||.....:|.:|       |.||......:..|..|.
  Rat   502 PSLAPGER--------------------LAGDPLLSKHMM-------APVAFKGETGNLLAFPPA 539

  Fly   812 FLPGLPAFQFAAAQVAAGGDGRGHYRFADSELQLPPGASMAGRLGESLIPKG--DPMEAKLQEML 874
            |..|..                            ||.|..|...|..  |.|  :|::....|
  Rat   540 FYGGAK----------------------------PPTAPAAPVPGPE--PSGAPEPVDGAGPE-- 572

  Fly   875 RYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGR 939
                    .:.|||..|:.:|:|.|..||||||:|..|:||||||:|||:|::||||.|||.||:
  Rat   573 --------EEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGK 629

  Fly   940 DSYRKMHAWACDDNAVMLLKSL------------IPKKDSGLPQYAGRGAGGAGGDDSMSEDRIA 992
            :.:.||..:..|:..|:.|:::            :|...|..|:......|        |:|.|.
  Rat   630 EPFIKMKQFLSDEQNVLALRTIQVRQRGPTAATFVPPPGSITPRIRTPETG--------SDDAIK 686

  Fly   993 HILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQ 1057
            .||.:|            :::.....|||       ||:.|.|.:.|.....:.       ..|.
  Rat   687 SILEQA------------KKEIESQKGGE-------SKNSPASVSIPNGTASSS-------TSED 725

  Fly  1058 AAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGA 1122
            |.....|:.|.:.:.:||..|..:.              .||..:.|               |..
  Rat   726 AIKNILEQARREMQAQQQALLEMES--------------GPRGRSVP---------------PSP 761

  Fly  1123 ASNAFPAMADENMRHVFEREIAKLQQHQ---QQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSL 1184
            .....||...:|      ..:|.::|..   ....:..|||.....|....:|:.:.....::..
  Rat   762 PERPSPATMSQN------GALACVKQEDGGCSSSSSGSAQAPLAVLSPAAFVQRIIRKVKSEIGD 820

  Fly  1185 AA------AAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSG 1243
            |.      |:.:.: |:...:|:..|..|||.........|:|.          |..|..||...
  Rat   821 AGYFDHHWASDRGL-LSRPYASVSPSLSSSSSYSGQPNGRAWPR----------GDEATIAPEDE 874

  Fly  1244 PGTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQP 1308
            ..||.|....   |..|.....|..|.:....||                            ..|
  Rat   875 AATGMGEDEA---PRVGELKAEAGVSEVGGGRLP----------------------------YYP 908

  Fly  1309 PVTPHHSTPQRPTKAVLPPITQQQFD--MFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQ 1371
            ...|      |..|..:||:|.:|::  |:..::|.::.|:|||.|::..|.||:|||.||||||
  Rat   909 AYVP------RTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQ 967

  Fly  1372 GSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMP 1436
            |||||:|:|||||..||||||||||||:::|.|:                        .|..|.|
  Rat   968 GSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQ------------------------LGQGQAP 1008

  Fly  1437 QGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQ 1501
            ....|..||:  |.:...|......|.:.:...|:....::.::.:.||
  Rat  1009 NQQPSASQAS--PTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQ---------------- 1055

  Fly  1502 HLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQP 1566
                                      .:..|::          |..|.|    :|...:.||.|
  Rat  1056 --------------------------PEGRASS----------TLGGKP----LSSSQTTGGIQ- 1079

  Fly  1567 GGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALL 1631
                                                      ||.|::.:|||:.||.::||.|.
  Rat  1080 ------------------------------------------EMVAMSPELDTYSITKRVKEVLT 1102

  Fly  1632 ANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNER 1696
            .||:||::|||::|||:|||||:|||:|||||.||:||||||:||:|||||.:|||:|:.:|...
  Rat  1103 DNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMRLWLSDPHNVEKLRDVKKLE 1167

  Fly  1697 REASKRRR----STGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQK 1757
            ::|..:||    |||          |.:::...::..|.|......: ....:||.||:.:..:|
  Rat  1168 KKAYLKRRYGLISTG----------SDSESPAAHSECPSPCLQPQEL-SLMQAKKPRVVLAPAEK 1221

  Fly  1758 EALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQV---------PHGPAGQDN 1813
            ||||.|:.|:|||:..|||.|:.:|.|.|.|:.|||||:|.|:::::         ...|:|..:
  Rat  1222 EALRKAYQLEPYPSQQTIELLSFQLNLKTNTVVNWFHNYRSRMRREMLVEGTQDDPDFDPSGGSS 1286

  Fly  1814 PIPSRES-TSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAA 1877
            .:||..: |..||..|..          |:..::..|....:..|......|...|::..|
  Rat  1287 VLPSGHTHTDPTPQSPDS----------EIEDQKPPMKSLELQEPESPVHQAAPDRAVVKI---- 1337

  Fly  1878 AAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDL---SMPTLKRERSDDYQDDLELEGG---- 1935
                                        :|..||::   |.|       .|..|....:||
  Rat  1338 ----------------------------KQEEGLEVDGDSQP-------QDIGDPDRGQGGPKEE 1367

  Fly  1936 -GHNLSDNE--------SLEG---------QEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRR 1982
             .|.|.:||        .|.|         ..|:.|.|..:  :|...|    ::.|.:..|...
  Rat  1368 DTHPLGNNELSELVPGPFLPGTPNPDCSSLHTPQAKETGEQ--VHSEPL----SFKSTSESSCCS 1426

  Fly  1983 KPAAPQWVNPAGAVTNPSAVVAAVAAAAAAA 2013
            ....|   |...|:::|..:.....|.:::|
  Rat  1427 LEGPP---NSPSAISSPDLMTCVSPAPSSSA 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	37/68 (54%)
		CUT	1335..1411	CDD:280527	44/75 (59%)
		CUT	1616..1690	CDD:280527	49/73 (67%)
		Homeobox	1749..1801	CDD:278475	27/51 (53%)
Cux2	XP_038945174.1	SMC_prok_B	<185..>388	CDD:274008	47/244 (19%)
		CUT	572..648	CDD:396794	39/85 (46%)
		CUT	931..1004	CDD:396794	44/96 (46%)
		CUT	1084..1160	CDD:396794	49/75 (65%)
		Homeobox	1212..1266	CDD:395001	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335063
Domainoid	1	1.000	116	1.000	Domainoid score	I5812
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2158
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101540at33208
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm45180
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000