DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and CUX2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_011536365.1	Gene:	CUX2 / 23316	HGNCID:	19347	Length:	1497	Species:	Homo sapiens

Alignment Length:	1963	Identity:	457/1963 - (23%)
Similarity:	677/1963 - (34%)	Gaps:	677/1963 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 QSGGVGGACLNPKLFFNHAQQMMMMEAAAAAAAAALQQQQQQQSPLH-------------SPANE 219
            :||.|.|....|.......|::...|..:.|:..:.:|::.:.|..|             ....|
Human    54 RSGAVSGHFWEPWTALERRQELPRKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIRE 118

  Fly   220 VAIPTEQ--PAATVATGAAAAAAAAA------TPIATGNVKSGSTTSNANHTNSNNSHQD----- 271
            :..|..:  .|..||....:..|.||      ..|.....:.|  ||.|..|.:..|...
Human   119 MVAPVLKSFQAEVVALSKRSQEAEAAFLSVYKQLIEAPEQREG--TSPAGPTLTEGSRLPGIPGK 181

  Fly   272 ---EEELDDEEEDEEEDEDEDDEEENASMQSNADDMEL-------DAQQETRTEPSATTQQQHQQ 326
               .|.|....|.|:              |....::::       :|:::.:...||....|.:.
Human   182 ALLTETLLQRNEAEK--------------QKGLQEVQITLAARLGEAEEKIKVLHSALKATQAEL 232

  Fly   327 QDTE---DLEENKDAGEASLNVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSAEDDDCANNNTN 388
            .:..   |.|....|.|..|.::|           ..|.|.....:::.|.|..|.
Human   233 LELRRKYDEEAASKADEVGLIMTN-----------LEKANQRAEAAQREVESLREQ--------- 277

  Fly   389 TSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNNNNNNG-QPAVLLAAKDKEIKALLDELQRL 452
                       .::.|::......|.......|.|....:| :....||:||:||..||.::|.|
Human   278 -----------LASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHL 331

  Fly   453 RAQ----EQTHLVQIQRLEEHLEVKRQHIIRLEARLDKQ-QINEALAEATALSAAASTNNNNNSQ 512
            ::.    |:....||..||..|..|.:.|.:||.:|..| ...|...|.:.|.|
Human   332 QSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKA----------- 385

  Fly   513 SSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQAMLVDSEEAEDKPEDSHHDDDE 577
                 .||         |||...||:...                         |||||
Human   386 -----MKL---------ASSTCSLPQGMA-------------------------KPEDS------ 405

  Fly   578 DEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAAAAAAAAAACANDPNKFQALLIE 642
                              |.|.||...|.                              |..|:|
Human   406 ------------------LLIAKEAFFPT------------------------------QKFLLE 422

  Fly   643 RTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSGSNSN 707
            :...||:........|::.:....:|.....||                    |...|......:
Human   423 KPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQ--------------------LPPPPGPEDPLS 467

  Fly   708 PASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANSTAQLA 772
            |:.          |..||.||    |....|.:.|.|..|
Human   468 PSP----------GQPLLGPS----LGPDGTRTFSLSPFP------------------------- 493

  Fly   773 ASLASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGRGHYR 837
             ||||   |.:.:|       ...|....|.......|.|....|  ..|.|..|.|.:..|...
Human   494 -SLAS---GERLMM-------PPAAFKGEAGGLLVFPPAFYGAKP--PTAPATPAPGPEPLGGPE 545

  Fly   838 FADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVH 902
            .||.     .|...||...|                         .:.|||..|:.:|:|.|..|
Human   546 PADG-----GGGGAAGPGAE-------------------------EEQLDTAEIAFQVKEQLLKH 580

  Fly   903 NIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSL-IPKKD 966
            |||||:|..|:||||||:|||:|::||||.|||.||::.:.||..:..|:..|:.|::: :.::.
Human   581 NIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRG 645

  Fly   967 SGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKS 1031
            |..|:......|        |:|.|..||.:|            :::.....|||
Human   646 SITPRIRTPETG--------SDDAIKSILEQA------------KKEIESQKGGE---------- 680

  Fly  1032 PPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIAR 1096
             |::..:|       |.......|...:....:...||..||.|.:       :.|.|..|:
Human   681 -PKTSVAP-------LSIANGTTPASTSEDAIKSILEQARREMQAQ-------QQALLEMEV--- 727

  Fly  1097 TPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQQQQAAQAQAQ 1161
            .||..:.|.   ||.   ....:..|:.|..||:.                 .|::.....|||.
Human   728 APRGRSVPP---SPP---ERPSLATASQNGAPALV-----------------KQEEGSGGPAQAP 769

  Fly  1162 FPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHG 1226
            .|..|. .|..|.::...:. .:..|...|......|..|.....|.|.|........|....:|
Human   770 LPVLSP-AAFVQSIIRKVKS-EIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNG 832

  Fly  1227 RK-SEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAAT 1290
            |. ..|...|.||...:..|.....|.|......||::.:.|..|...:.:|
Human   833 RAWPRGDEAPVPPEDEAAAGAEDEPPRTGELKAEGATAEAGARLPYYPAYVP------------- 884

  Fly  1291 ASPLQRMASITNSLITQPPVTPHHSTPQRPTKAVLPPITQQQFD--MFNNLNTEDIVRRVKEALS 1353
                                        |..|..:||:|.:|::  |:..::|.::.|:|||.|:
Human   885 ----------------------------RTLKPTVPPLTPEQYELYMYREVDTLELTRQVKEKLA 921

  Fly  1354 QYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKI 1418
            :..|.||:|||.|||||||||||:|:|||||..||||||||||||:::|.|:  :.:.|..|
Human   922 KNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLSDQ--LGQAVGQQ--- 981

  Fly  1419 APEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQ 1483
                   .|:...||..|:...|...:.:.|      |...|||              :|.:::.
Human   982 -------PGASQASPTEPRSSPSPPPSPTEP------EKSSQEP--------------LSLSLES 1019

  Fly  1484 QQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPG 1548
            .:                                 :.|.|  :...:::.:..::
Human  1020 SK---------------------------------ENQQP--EGRSSSSLSGKMY---------- 1039

  Fly  1549 LPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAAL 1613
                        :|...|||                                      :.|:.|:
Human  1040 ------------SGSQAPGG--------------------------------------IQEIVAM 1054

  Fly  1614 TQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQL 1678
            :.:|||:.||.::||.|..||:||::|||::|||:|||||:|||:|||||.||:||||||:||||
Human  1055 SPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQL 1119

  Fly  1679 WLSDANNVERLQLLKNERREASKRRR----STGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGV 1739
            ||:|.:|||:|:.:|...::|..:||    |||       ||:.|..|.   :..|.|
Human  1120 WLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTG-------SDSESPATR---SECPSP------- 1167

  Fly  1740 GGAPPS-------KKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHR 1797
             ...|.       ||.||:.:.|:|||||.|:.|:|||:..|||.|:.:|.|.|.|:.|||||:|
Human  1168 -CLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYR 1231

  Fly  1798 MRLKQQV------------PHG-----PAGQDNPIPS-------------------------RES 1820
            .|:::::            |.|     |.|..:|.|:                         ..|
Human  1232 SRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENS 1296

  Fly  1821 TSATPFDPVQFRILLQQRLLELHKERMGM-----------SGAP---IPYPPYFAAAAILGRSLA 1871
            |..|..|..|.|| .|:::.|..:|..|.           .|.|   .|.||        |..
Human  1297 TPLTTQDKAQVRI-KQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPP--------GND-- 1350

  Fly  1872 GIPGAAAAAGAAAAAAAVGASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGG 1936
            |:|      ..|......|.|..|                   .|:|..::        |.|.|.
Human  1351 GLP------KVAPGPLLPGGSTPD-------------------CPSLHPQQ--------ESEAGE 1382

  Fly  1937 HNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGAVTNPSA 2001
            ....|..|.:......:.:....:...||.::....||.:...|...|.:|   :|.||  .|:.
Human  1383 RLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISP---SPPGA--PPAK 1442

  Fly  2002 VVAAVAAAAAAAA 2014
            |.:|...|..|.|
Human  1443 VPSASPTADMAGA 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	37/68 (54%)
		CUT	1335..1411	CDD:280527	44/75 (59%)
		CUT	1616..1690	CDD:280527	49/73 (67%)
		Homeobox	1749..1801	CDD:278475	28/51 (55%)
CUX2	XP_011536365.1	CUT	564..633	CDD:280527	37/68 (54%)
		CUT	903..976	CDD:280527	44/74 (59%)
		CUT	1054..1130	CDD:280527	49/75 (65%)
		Homeobox	1182..1235	CDD:278475	28/52 (54%)
		PHA03418	1250..>1389	CDD:177646	35/182 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141395
Domainoid	1	1.000	116	1.000	Domainoid score	I5966
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1647
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101540at33208
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm41044
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R168
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.030