DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Onecut2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_919244.2	Gene:	Onecut2 / 225631	MGIID:	1891408	Length:	505	Species:	Mus musculus

Alignment Length:	628	Identity:	144/628 - (22%)
Similarity:	218/628 - (34%)	Gaps:	211/628 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1231 GGGTP-------APPAPPSGPGTGAGA-----PPTAAPPTGGASSNSAAPSPLSNSILPPALSS- 1282
            |||.|       |.|:|.......||:     ||||....|.|::.:||   .|.|.:..:::|
Mouse    51 GGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPTAHQELGTAAAAAAA---ASRSAMVTSMASI 112

  Fly  1283 -QGEEFAATAS-PLQRMASITNSLITQPP-----VTPHHSTPQRPTKAVLPPITQQQFDMFNNLN 1340
             .|.::....| ||....|:  |..:.||     .|....||.:|    ||||:
Mouse   113 LDGSDYRPELSIPLHHAMSM--SCDSSPPGMGMSNTYTTLTPLQP----LPPIS----------- 160

  Fly  1341 TEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDE 1405
                                            :|||....|.|.|
Mouse   161 --------------------------------TVSDKFHHPHPHH-------------------- 173

  Fly  1406 NAVHKLVASQYKIAPEKLMRTGSYSGSPQM---PQGLASKMQAASLPMQKMMSELKLQEPAQAQH 1467
               |......:....::|  :|:.|||..:   .:||.|        |..:.|..| :.|:.:|.
Mouse   174 ---HPHHHHHHHHHHQRL--SGNVSGSFTLMRDERGLPS--------MNNLYSPYK-EMPSMSQS 224

  Fly  1468 LMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPH---QQHHQ 1529
            | ..:.|..:...:                               ...|.|||..|:   ..|.:
Mouse   225 L-SPLAATPLGNGL-------------------------------GGLHNAQQSLPNYGPPGHDK 257

  Fly  1530 AAAAAAALHHQSMLLTSPGLPPQH---AISLPPSAGGAQPGG---PGGNQGSSNPSNSEKKPMLM 1588
            ..:.....||.:||...    .||   .:..||:|..:...|   ||..|...        |:|.
Mouse   258 MLSPNFDAHHTAMLTRG----EQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHG--------PVLA 310

  Fly  1589 PVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVS 1653
            |........|     |.:....:...::::|.::..:|...|...:|.|.||.:.||..|||::|
Mouse   311 PSRERPPSSS-----SGSQVATSGQLEEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLS 370

  Fly  1654 ELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTS 1718
            :||..||||..|. .|||.|.||..||.:. ..:|:..|    |.|:.:|:...||:..|:|
Mouse   371 DLLRNPKPWSKLK-SGRETFRRMWKWLQEP-EFQRMSAL----RLAACKRKEQEPNKDRNNS--- 426

  Fly  1719 SNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELG 1783
                                      .||.|::|::.|:..|...|..:..|:......::.:||
Mouse   427 --------------------------QKKSRLVFTDLQRRTLFAIFKENKRPSKEMQITISQQLG 465

  Fly  1784 LATRTITNWFHNHRMRL--KQQVPHGPAGQDNPIPSRESTSAT 1824
            |...|::|:|.|.|.|.  |.|...|..|.       .|||:|
Mouse   466 LELTTVSNFFMNARRRSLEKWQDDLGTGGS-------SSTSST 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	7/75 (9%)
		CUT	1616..1690	CDD:280527	29/73 (40%)
		Homeobox	1749..1801	CDD:278475	15/53 (28%)
Onecut2	NP_919244.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..94		14/42 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..190		5/49 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..333		14/70 (20%)
		CUT	332..404	CDD:308148	28/73 (38%)
		HOX	427..482	CDD:197696	16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910