DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Satb2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_006495890.1	Gene:	Satb2 / 212712	MGIID:	2679336	Length:	740	Species:	Mus musculus

Alignment Length:	899	Identity:	169/899 - (18%)
Similarity:	284/899 - (31%)	Gaps:	322/899 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1227 RKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNSAAPSPLS-----NSILPPALSSQGEE 1286
            |:||.      |.....|...:|:|....||....:......||:.     |..:..|:.....|
Mouse     3 RRSES------PCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGNSPE 61

  Fly  1287 FAATASPLQRMASITNSLITQPPVTPHHSTPQRPTKAVLPPITQQQFDMFNNLNTEDIVRRVKEA 1351
            ......|:       ..::.|...:..:...:...:.||    .::..:|:.|        |:.|
Mouse    62 LGGLMIPV-------FCVVEQLDGSLEYDNREEHAEFVL----VRKDVLFSQL--------VETA 107

  Fly  1352 LSQ--YSISQRLFGESVLGLSQ--------------GSVSDLLARPKPWHMLTQKGREPFIRMKM 1400
            |..  ||.|.....:.::.|.:              .:|:|:|  ...:|::|         :|:
Mouse   108 LLALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADML--QDVYHVVT---------LKI 161

  Fly  1401 FLEDENAVHKLVASQY-----KIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPM-QKMMSEL-- 1457
            .|:..:.:..|.|.|:     :.|.::|::        :|.|...:|    ..|: |.|:|.:
Mouse   162 QLQSCSKLEDLPAEQWNHATVRNALKELLK--------EMNQSTLAK----ECPLSQSMISSIVN 214

  Fly  1458 ----------KLQE---------------------------PAQAQHLMQQMQAAAMSAAMQQQQ 1485
                      |.||                           ..:..||....|.|::....:|..
Mouse   215 STYYANVSATKCQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSP 279

  Fly  1486 VAQA--------QQQAQQAQQAQQHLQQQAQQHLQQQQ----HLAQQQHPHQQHHQAAAAAAALH 1538
            .:|.        |..|.|...:...|..|....|.:||    ||..||         .|.:..|.
Mouse   280 HSQIHHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQ---------IAVSRLLA 335

  Fly  1539 HQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHM 1603
            ||     .|....|..::.||.....:|          .|:||..:                  :
Mouse   336 HQ-----HPQAINQQFLNHPPIPRAVKP----------EPTNSSVE------------------V 367

  Fly  1604 SPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWH----- 1663
            ||.:|:               ::::.|...::.|.:|.......:||.:||:|.|.:...
Mouse   368 SPDIYQ---------------QVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQS 417

  Fly  1664 -MLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRSTGPN---QQDNSSDTSSNDTND 1724
             :::::..:.|:.:.       .|||.::.::|      |.||..||   ....||..||:.|..
Mouse   418 LLVNLRAMQNFLNLP-------EVERDRIYQDE------RERSMNPNVSMVSSASSSPSSSRTPQ 469

  Fly  1725 FYTSSPG---PGSV-GSGVGGAPPSKKQRVLFSEEQKEALR-----------------------L 1762
            ..||:|.   |..| |:.|      .....::.|.|:|..|                       |
Mouse   470 AKTSTPTTDLPIKVDGANV------NITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELL 528

  Fly  1763 AFALDPYP-------NVGTIEFLAN----ELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIP 1816
            .:..:|.|       |:.||....|    |..:.....:...|:.||:...|:|.
Mouse   529 RWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPP---------- 583

  Fly  1817 SRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAG 1881
                      :|||  :|.:|:.....:.......||.|.||...:.|...||...|
Mouse   584 ----------EPVQ--VLHRQQSQPTKESSPPREEAPPPPPPTEDSCAKKPRSRTKI-------- 628

  Fly  1882 AAAAAAAVGASGGDELQAL---------NQAFKEQMSGLDLSMPT-----------------LKR 1920
               :..|:|.     ||:.         .:|.....:.|||...|                 ||.
Mouse   629 ---SLEALGI-----LQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKE 685

  Fly  1921 ERSD-----DYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYEKVLHKSALAAA 1969
            ....     :|:|:..|.    ...:|:|.||.|...|....|:...||..|.|
Mouse   686 HLGSAVDVAEYKDEELLT----ESEENDSEEGSEEMYKVEAEEENADKSKAAPA 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	16/91 (18%)
		CUT	1616..1690	CDD:280527	13/79 (16%)
		Homeobox	1749..1801	CDD:278475	15/85 (18%)
Satb2	XP_006495890.1	SATB1_N	67..162	CDD:211426	19/124 (15%)
		CUTL	169..239	CDD:406861	15/81 (19%)
		CUT	362..440	CDD:396794	18/117 (15%)
		CUT	484..563	CDD:396794	14/84 (17%)
		HOX	621..678	CDD:197696	12/72 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910