DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and DLX2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	438	Identity:	92/438 - (21%)
Similarity:	128/438 - (29%)	Gaps:	161/438 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1528 HQAAAAAAALHHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPV-- 1590
            |....||::.:||.              ..|||.|||   |||||..||:..:..::...:||
Human    13 HSTQIAASSTYHQH--------------QQPPSGGGA---GPGGNSSSSSSLHKPQESPTLPVST 60

  Fly  1591 -----HGTNAMR---------SLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFG 1641
                 :.||...         |.:.||....|:.:.|                   ||:......
Human    61 ATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGL-------------------NNVPYSAKS 106

  Fly  1642 EAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRST 1706
            ...||.:....|.     .|:...|              |.|||....:.|:.|.|.
Human   107 SYDLGYTAAYTSY-----APYGTSS--------------SPANNEPEKEDLEPEIRI-------- 144

  Fly  1707 GPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPS-KKQRVLFSEEQKEALRLAFALDPYP 1770
                                            |.|.|.. :|.|.::|..|..||:..|....|.
Human   145 --------------------------------VNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYL 177

  Fly  1771 NVGTIEFLANELGLATRTITNWFHNHRMRLKQQVPHGPAGQDNPIPSRE--STSATPFDPVQFRI 1833
            .:.....||..|||....:..||.|.|.:.|:....|      .|||.:  ..||:|
Human   178 ALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSG------EIPSEQHPGASASP-------- 228

  Fly  1834 LLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIP-GAAAAAGAAAAAAAVGASGGDEL 1897
                               |...||..|.|:    ...|:| ..|...|..:..:..|:||....
Human   229 -------------------PCASPPVSAPAS----WDFGVPQRMAGGGGPGSGGSGAGSSGSSPS 270

  Fly  1898 QAL-----NQAFKEQMSG----LDLSMPTLKRERSDDYQDDLELEGGG 1936
            .|.     |..:..|.||    |..:.|.|...::..........|||
Human   271 SAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGG 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	11/73 (15%)
		Homeobox	1749..1801	CDD:278475	16/51 (31%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		21/81 (26%)
		DLL_N	51..132	CDD:289198	19/118 (16%)
		Homeobox	155..208	CDD:278475	16/52 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		19/95 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910