DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and NKX2-3

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_660328.2	Gene:	NKX2-3 / 159296	HGNCID:	7836	Length:	364	Species:	Homo sapiens

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	130/435 - (29%)	Gaps:	165/435 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1591 HGTNAMRSL--HQHMSPTVYEMAALTQ-----DLDTHDITTKIK--EALLANNIGQKIFGEAVLG 1646
            ||.:....|  |.|.:|.:...|..||     :.|..|...|:.  .:|.|.:      |....|
Human    28 HGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGEEDEEDEGEKLSYLNSLAAAD------GHGDSG 86

  Fly  1647 L-SQGSVSELL----SKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRRRST 1706
            | .||.|..:|    |:||                                ::|......|.||.
Human    87 LCPQGYVHTVLRDSCSEPK--------------------------------EHEEEPEVVRDRSQ 119

  Fly  1707 GPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAFALDPYPN 1771
            ...|...|.:|:.:......:..|.|.|          .:|.|||||:.|...|...|....|.:
Human   120 KSCQLKKSLETAGDCKAAEESERPKPRS----------RRKPRVLFSQAQVFELERRFKQQRYLS 174

  Fly  1772 VGTIEFLANELGLATRTITNWFHNHRMRLKQQ--------VPHGPAGQDNPIPSRESTSATPFDP 1828
            ....|.||:.|.|.:..:..||.|.|.:.|:|        ..|.|.    |.|.|.:.      |
Human   175 APEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPP----PPPRRVAV------P 229

  Fly  1829 VQFRILLQQRLLELHKERMGMSGAPIPYP-------PYFAAAAI----------LGRSLAGIPGA 1876
            |..|                 .|.|...|       ||...|:.          .|.|.|   .|
Human   230 VLVR-----------------DGKPCVTPSAQAYGAPYSVGASAYSYNSFPAYGYGNSAA---AA 274

  Fly  1877 AAAAGAAAAAAAV-----------GASGGDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDL 1930
            ||||.|||||||.           |..||....|...|.:...|.
Human   275 AAAAAAAAAAAAYSSSYGCAYPAGGGGGGGGTSAATTAMQPACSA-------------------- 319

  Fly  1931 ELEGGG-----HNLSDNESLEGQEPEDKTTDYEKVLHKSALAAAA 1970
              .|||     .||....|....:|          ||:...|.||
Human   320 --AGGGPFVNVSNLGGFGSGGSAQP----------LHQGTAAGAA 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527	15/80 (19%)
		Homeobox	1749..1801	CDD:278475	18/51 (35%)
NKX2-3	NP_660328.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..153		4/30 (13%)
NKX2-3	NP_660328.2	HOX	148..204	CDD:197696	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910