DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and NKX2-6

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001129743.2	Gene:	NKX2-6 / 137814	HGNCID:	32940	Length:	301	Species:	Homo sapiens

Alignment Length:	172	Identity:	50/172 - (29%)
Similarity:	69/172 - (40%)	Gaps:	24/172 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1731 GPGSVGSGVGG-------APPSKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRT 1788
            |.|:.|..|.|       |...:|.|||||:.|..||...|....|.:....|.||:.|.|.:..
Human   111 GVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQLTSTQ 175

  Fly  1789 ITNWFHNHRMRLKQQVPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMS-GA 1852
            :..||.|.|.:.|:|      .||..:    ..:..|..|.:..:.:   |:...|..:|.. ||
Human   176 VKIWFQNRRYKCKRQ------RQDKSL----ELAGHPLTPRRVAVPV---LVRDGKPCLGPGPGA 227

  Fly  1853 PIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASGG 1894
            | .:|..::||........|..||...||.....|  ||..|
Human   228 P-AFPSPYSAAVSPYSCYGGYSGAPYGAGYGTCYA--GAPSG 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475	19/51 (37%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..135		6/23 (26%)
NKX2-6	NP_001129743.2	HOX	132..188	CDD:197696	20/55 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910