DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and NOBOX

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001073882.3	Gene:	NOBOX / 135935	HGNCID:	22448	Length:	691	Species:	Homo sapiens

Alignment Length:	600	Identity:	116/600 - (19%)
Similarity:	168/600 - (28%)	Gaps:	233/600 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   861 PKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELL 925
            |:.||:|             ...|:|..:.:....|||......|::       .|:.|...|.|
Human    71 PQHDPLE-------------IPEQSLKLIPLVSGKRELTRGQKAGEK-------PLAAGPGEEEL 115

  Fly   926 ---SKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAGG-AGGDDSM 986
               |.|...|..:|:                   |..|.....:...|..:|...|. ||.....
Human   116 LRGSAPHAQDTQSEE-------------------LPPSCTISGEKKPPAVSGEATGADAGRLCPP 161

  Fly   987 SEDRIAHILSEASSLMKQSSVAQHREQE---------------RRSHG---GEDSHSNEDSKSPP 1033
            ...|..|         |..::|:.|.|.               :||:.   |:....|....:|.
Human   162 PRSRAPH---------KDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPT 217

  Fly  1034 QSCTSP--------------------------FFKVENQLKQHQHLNPEQAAAQQREREREQRER 1072
            .|..:|                          .....||.:.|:. .|.:...|.|::.|.....
Human   218 SSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQ-GPPEVTCQIRKKTRTLYRS 281

  Fly  1073 EQQQRL-------RHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAM 1130
            :|.:.|       .:.|.||...:.| .:..||:..          :..||..:....|...|.:
Human   282 DQLEELEKIFQEDHYPDSDKRREIAQ-TVGVTPQRI----------MVKGAGSLVAGWSGGGPTI 335

  Fly  1131 ADENMRHVFEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLN 1195
                       |..:|    |.:::|.|...|.|                   ..|...|..|||
Human   336 -----------ETLEL----QSERSAVAWVWFQN-------------------RRAKWRKMEKLN 366

  Fly  1196 GQRSSLEHSA---GSSSCSKDGE---------RDDAYPSSLHGRKSEGGGTPAPP--------AP 1240
            |:.|....:|   .||.||...|         :.|.:|     ::|.....|.||        ..
Human   367 GKESKDNPAAPGPASSQCSSAAEILPAVPMEPKPDPFP-----QESPLDTFPEPPMLLTSDQTLA 426

  Fly  1241 PSGPGTGAG---APPTAAPP--------------------------TGGASSNSAAP-SPLSNSI 1275
            |:.|..||.   .||..:||                          .|..||:...| .....||
Human   427 PTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPLLMDVAGSDSSHKDGPCGSWGTSI 491

  Fly  1276 -LPP------ALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHSTPQ------------RPT 1321
             |||      .|..|..:.:....|.|         .:|.|..|...:||            .|:
Human   492 TLPPPCSYLEELEPQDYQQSNQPGPFQ---------FSQAPQPPLFQSPQPKLPYLPTFPFSMPS 547

  Fly  1322 KAVLPPITQQQFDMF 1336
            ...|||.....| ||
Human   548 SLTLPPPEDSLF-MF 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	13/71 (18%)
		CUT	1335..1411	CDD:280527	1/1 (100%)
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
NOBOX	NP_001073882.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..233		31/173 (18%)
		homeodomain	273..363	CDD:238039	22/134 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..385		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..437		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910